DE602004018836D1 - Proteinphosphorylierung in c-src-signalwegen - Google Patents

Proteinphosphorylierung in c-src-signalwegen

Info

Publication number
DE602004018836D1
DE602004018836D1 DE602004018836T DE602004018836T DE602004018836D1 DE 602004018836 D1 DE602004018836 D1 DE 602004018836D1 DE 602004018836 T DE602004018836 T DE 602004018836T DE 602004018836 T DE602004018836 T DE 602004018836T DE 602004018836 D1 DE602004018836 D1 DE 602004018836D1
Authority
DE
Germany
Prior art keywords
modified peptide
specific antibody
modification
preparation
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004018836T
Other languages
English (en)
Inventor
Albrecht Moritz
Kimberly Lee
John Rush
Roberto Polakiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Signaling Technology Inc
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Publication of DE602004018836D1 publication Critical patent/DE602004018836D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE602004018836T 2004-02-12 2004-08-12 Proteinphosphorylierung in c-src-signalwegen Expired - Fee Related DE602004018836D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/777,893 US7300753B2 (en) 1998-09-04 2004-02-12 Immunoaffinity isolation of modified peptides from complex mixtures
PCT/US2004/026199 WO2005083113A1 (en) 2004-02-12 2004-08-12 Protein phosphorylation in c-src signaling pathways

Publications (1)

Publication Number Publication Date
DE602004018836D1 true DE602004018836D1 (de) 2009-02-12

Family

ID=34911345

Family Applications (3)

Application Number Title Priority Date Filing Date
DE602004018388T Expired - Fee Related DE602004018388D1 (de) 2004-02-12 2004-07-07 Proteinphosphorylierung bei grosszellig-anaplastischem lymphom
DE602004018836T Expired - Fee Related DE602004018836D1 (de) 2004-02-12 2004-08-12 Proteinphosphorylierung in c-src-signalwegen
DE602004018390T Expired - Fee Related DE602004018390D1 (de) 2004-02-12 2004-10-04 Proteinphosphorylierung in t-zellrezeptor-signalwegen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE602004018388T Expired - Fee Related DE602004018388D1 (de) 2004-02-12 2004-07-07 Proteinphosphorylierung bei grosszellig-anaplastischem lymphom

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602004018390T Expired - Fee Related DE602004018390D1 (de) 2004-02-12 2004-10-04 Proteinphosphorylierung in t-zellrezeptor-signalwegen

Country Status (8)

Country Link
US (1) US7300753B2 (de)
EP (3) EP1718976B1 (de)
JP (2) JP2005225858A (de)
AT (3) ATE417273T1 (de)
CA (3) CA2556021A1 (de)
DE (3) DE602004018388D1 (de)
ES (3) ES2317044T3 (de)
WO (3) WO2005083439A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9085609B2 (en) * 1998-09-04 2015-07-21 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US20120244594A9 (en) * 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20110111424A1 (en) * 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
DE60233574D1 (de) 2001-07-10 2009-10-15 Univ R Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2006083853A2 (en) * 2005-01-31 2006-08-10 Insilicos, Llc Methods of identification of biomarkers with mass spectrometry techniques
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CA2611365C (en) * 2005-06-14 2014-02-11 Cellzome Ag Process for the identification of novel enzyme interacting compounds
US7815418B2 (en) 2005-08-03 2010-10-19 Mitsubishi Heavy Industries, Ltd. Shroud and rotary vane wheel of propeller fan and propeller fan
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2007027957A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
WO2007064647A2 (en) * 2005-12-01 2007-06-07 New York Blood Center, Inc. Peptide inhibitors of abl kinases
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
SI2450437T1 (sl) 2006-04-14 2017-12-29 Cell Signaling Technology Inc. Okvarjenost genov in mutantna ALK kinaza v človeških solidnih tumorjih
US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
CA2982018C (en) * 2006-04-14 2023-10-17 Cell Signaling Technology, Inc. Gene defects and mutant alk kinase in human solid tumors
US20090298093A1 (en) * 2006-04-27 2009-12-03 Roberto Polakiewicz Reagents for the Detection of Protein Phosphorylation in ATM & ATR Kinase Signaling Pathways
WO2007133688A2 (en) * 2006-05-12 2007-11-22 Cell Signaling Technology, Inc. Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
WO2008009004A2 (en) * 2006-07-13 2008-01-17 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways
US20100151483A1 (en) * 2006-07-13 2010-06-17 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways
WO2008013948A2 (en) * 2006-07-27 2008-01-31 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CL2007002615A1 (es) * 2006-09-08 2008-04-18 Wyeth Corp Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.
AU2007338634A1 (en) * 2006-12-26 2008-07-03 Brigham Young University Serum proteomics system and associated methods
EP1975184A3 (de) * 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serin- oder Threonin-Phosphorylationsorte
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP2160752A4 (de) * 2007-05-23 2012-11-07 Nicholas A Williamson Verfahren zur massenanalyse von zielmolekülen in komplexen mischungen
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP2124060A1 (de) * 2008-05-23 2009-11-25 ETH Zurich Verfahren zur Assayerzeugung von Peptiden/Proteinen mit hohem Durchsatz und so erzeugte Assays
JP2009288160A (ja) * 2008-05-30 2009-12-10 Hitachi High-Technologies Corp 生体試料解析システム、生体試料解析手法、生体試料前処理装置及び生体試料前処理方法
US8106351B2 (en) 2008-08-08 2012-01-31 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
US7834313B2 (en) 2008-08-08 2010-11-16 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
EP2347263B1 (de) * 2008-10-03 2017-05-17 President and Fellows of Harvard College Verfahren, zusammensetzungen und kit für kinaseaktivitätsscreening mit hohem durchsatz anhand von massenspektrometrie und stabilen isotopen
US8907059B2 (en) * 2008-11-14 2014-12-09 Bio-Rad Laboratories, Inc. Phosphopeptide enrichment of compositions by fractionation on ceramic hydroxyapatite
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
JP5356282B2 (ja) * 2010-02-26 2013-12-04 大学共同利用機関法人自然科学研究機構 受容体型チロシンホスファターゼPtprzの活性測定用試薬及びその用途
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
US9249231B2 (en) 2010-11-05 2016-02-02 Cell Signaling Technology, Inc. Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
JPWO2012111249A1 (ja) * 2011-02-14 2014-07-03 学校法人麻布獣医学園 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法
EP2683736B1 (de) 2011-03-09 2018-01-17 Cell Signaling Technology, Inc. Verfahren und reagenzien zur erzeugung monoklonaler antikörper
EP2573565A1 (de) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immunnachweisverfahren für gemeinsame Epitope von zwei oder mehr Analyten in Proben mit komplexen Zusammensetzungen, Vorrichtung und Kit zum Ermöglichen dieses Immunnachweisverfahrens
JP2014532184A (ja) * 2011-10-12 2014-12-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill 多重化キナーゼ阻害剤ビーズ及びその使用
WO2013166605A1 (en) * 2012-05-09 2013-11-14 Dalhousie University Filtration and extraction assembly
CN103421792B (zh) * 2013-06-21 2015-03-25 浙江理工大学 真核生物翻译起始因子4H(eIF4H)基因沉默抑制肿瘤细胞生长的方法及其应用
WO2015120036A1 (en) * 2014-02-04 2015-08-13 University Of Virginia Patent Foundation Compositions and methods for analysis of protein sequences and post-translational modifications
EP3387430A4 (de) * 2015-12-11 2019-08-14 Expression Pathology, Inc. Srm/mrm-tests
US10927400B2 (en) * 2016-11-09 2021-02-23 Kendrick Laboratories, Inc. Protein standard compositions and methods of making and using the same
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
WO2019243590A1 (en) * 2018-06-21 2019-12-26 Universiteit Utrecht Holding B.V. Method for monitoring kinase activity in a sample
CN112812187B (zh) * 2021-01-18 2021-12-17 南昌大学第一附属医院 一种磷酸化eif5b特异性抗体及其制备方法与应用
CN114605497B (zh) * 2021-02-10 2023-04-28 北京欣安诚科技有限公司 一种dapk1磷酸化底物的人工小分子干扰肽及其制药用途
CN113061593B (zh) * 2021-04-02 2023-11-10 洛阳华荣生物技术有限公司 一种l-苹果酸脱氢酶突变体及其应用
CN113312056B (zh) * 2021-06-16 2022-04-19 浪潮云信息技术股份公司 angular大型集成项目的国际化实现方法、电子设备及存储介质

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962224A (en) 1995-12-19 1999-10-05 Dana-Farber Cancer Institute Isolated DNA encoding p62 polypeptides and uses therefor
US5885841A (en) 1996-09-11 1999-03-23 Eli Lilly And Company System and methods for qualitatively and quantitatively comparing complex admixtures using single ion chromatograms derived from spectroscopic analysis of such admixtures
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
CA2243230A1 (en) 1998-07-15 2000-01-15 Aled Edwards A device and method for the determination of protein domain boundaries
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US6441140B1 (en) 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US6379970B1 (en) 1999-04-30 2002-04-30 The Arizona Board Of Regents On Behalf Of The University Of Arizona Analysis of differential protein expression
US6579720B1 (en) * 1999-05-13 2003-06-17 Bdc Pharma Llc Method for activity profiling compound mixtures
US6818454B2 (en) * 2001-02-16 2004-11-16 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry

Also Published As

Publication number Publication date
ATE417276T1 (de) 2008-12-15
EP1718976A1 (de) 2006-11-08
EP1718760A1 (de) 2006-11-08
EP1718977B1 (de) 2008-12-10
ATE417273T1 (de) 2008-12-15
US7300753B2 (en) 2007-11-27
CA2556022A1 (en) 2005-09-09
ES2317044T3 (es) 2009-04-16
WO2005083113A1 (en) 2005-09-09
ES2321197T3 (es) 2009-06-03
EP1718977A1 (de) 2006-11-08
ATE419379T1 (de) 2009-01-15
ES2321520T3 (es) 2009-06-08
JP2005225858A (ja) 2005-08-25
JP2007308506A (ja) 2007-11-29
CA2556021A1 (en) 2005-09-09
WO2005083439A1 (en) 2005-09-09
DE602004018388D1 (de) 2009-01-22
EP1718760B1 (de) 2008-12-31
CA2556019A1 (en) 2005-09-09
US20050003450A1 (en) 2005-01-06
WO2005083444A1 (en) 2005-09-09
EP1718976B1 (de) 2008-12-10
DE602004018390D1 (de) 2009-01-22

Similar Documents

Publication Publication Date Title
DE602004018836D1 (de) Proteinphosphorylierung in c-src-signalwegen
Iwabata et al. Proteomic analysis of organ‐specific post‐translational lysine‐acetylation and‐methylation in mice by use of anti‐acetyllysine and‐methyllysine mouse monoclonal antibodies
EP3729958B1 (de) Identifizierung und überwachung von monoklonalen immunglobulinen nach molekülmasse
JP2013507603A (ja) 署名ペプチドおよび質量分析による混合物中の個々の組換えタンパク質の多重定量化
RU2009120683A (ru) Соединения и способы двойного мечения полипептидов, предоставляющие возможность мультиплексирования при масс-спектрометрическом анализе
CN105277712B (zh) 一种鉴定赖氨酸ε‑氨基侧链单甲基化修饰的方法
US20230349903A1 (en) Assays and reagents for characterization of mhci peptide binding
WO2006044666A3 (en) Detection of disease associated proteolysis by direct mass spectrometry analysis of low molecular weight peptides
Pipes et al. Middle‐down fragmentation for the identification and quantitation of site‐specific methionine oxidation in an IgG1 molecule
RU2007124371A (ru) Антитела и пептидные антигены для получения антител, имеющих селективную специфичность связывания с биологически активным интактным паратиреоидным гормоном (птг(ртн))1-84
Cho et al. A yeast display immunoprecipitation method for efficient isolation and characterization of antigens
Kim et al. Mapping protein receptor–ligand interactions via in vivo chemical crosslinking, affinity purification, and differential mass spectrometry
WO2017104289A1 (ja) タンパク質の検出方法及び免疫測定方法
US20070293437A1 (en) Expression Profiling Platform Technology
WO2003062444A3 (en) Array systems and methods
Volk et al. Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis
CA2454605A1 (en) Immunoaffinity isolation of modified peptides from complex mixtures
Korbakis et al. Delineating monoclonal antibody specificity by mass spectrometry
WO2004084841A3 (en) Novel anti-feline albumin antibodies and methods of detecting early renal disease
US20220034902A1 (en) Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries
JP6712369B2 (ja) 抗ペプチド抗体の製造方法及び設計方法
Cao et al. Evaluation of N-terminal labeling mass spectrometry for characterization of partially hydrolyzed gluten proteins
JP6358630B2 (ja) 免疫測定方法
RU2009120481A (ru) Анализ протеолитического расщепления с помощью масс-спектрометрии
Roepstorff et al. A general strategy for the use of mass spectrometric molecular weight information in protein purification and sequence determination

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee