DE602004007278D1 - Verfahren zur enantioselektiven synthese von einzelnen modafinilenantiomeren durch asymmetrische oxidation - Google Patents

Verfahren zur enantioselektiven synthese von einzelnen modafinilenantiomeren durch asymmetrische oxidation

Info

Publication number
DE602004007278D1
DE602004007278D1 DE602004007278T DE602004007278T DE602004007278D1 DE 602004007278 D1 DE602004007278 D1 DE 602004007278D1 DE 602004007278 T DE602004007278 T DE 602004007278T DE 602004007278 T DE602004007278 T DE 602004007278T DE 602004007278 D1 DE602004007278 D1 DE 602004007278D1
Authority
DE
Germany
Prior art keywords
modafinilene
antiomers
individual
enantioselective synthesis
asymmetric oxidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004007278T
Other languages
English (en)
Other versions
DE602004007278T2 (de
Inventor
Francois Rebiere
Gerard Duret
Laurence Prat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Cephalon France SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Cephalon France SAS filed Critical Cephalon France SAS
Publication of DE602004007278D1 publication Critical patent/DE602004007278D1/de
Application granted granted Critical
Publication of DE602004007278T2 publication Critical patent/DE602004007278T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE602004007278T 2003-09-19 2004-09-17 Verfahren zur enantioselektiven synthese von einzelnen modafinilenantiomeren durch asymmetrische oxidation Active DE602004007278T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03292312A EP1516869A1 (de) 2003-09-19 2003-09-19 Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung
EP03292312 2003-09-19
US50708903P 2003-10-01 2003-10-01
US507089P 2003-10-01
PCT/IB2004/003026 WO2005028428A1 (en) 2003-09-19 2004-09-17 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Publications (2)

Publication Number Publication Date
DE602004007278D1 true DE602004007278D1 (de) 2007-08-09
DE602004007278T2 DE602004007278T2 (de) 2008-02-28

Family

ID=34178643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004007278T Active DE602004007278T2 (de) 2003-09-19 2004-09-17 Verfahren zur enantioselektiven synthese von einzelnen modafinilenantiomeren durch asymmetrische oxidation

Country Status (21)

Country Link
US (2) US7317126B2 (de)
EP (2) EP1516869A1 (de)
JP (1) JP4713480B2 (de)
KR (1) KR101136703B1 (de)
CN (1) CN100404502C (de)
AT (1) ATE365711T1 (de)
AU (1) AU2004274248B2 (de)
BR (1) BRPI0414298B1 (de)
CA (1) CA2538697C (de)
DE (1) DE602004007278T2 (de)
DK (1) DK1663963T3 (de)
EA (1) EA009385B1 (de)
ES (1) ES2289556T3 (de)
MX (1) MXPA06002935A (de)
NZ (1) NZ545739A (de)
PL (1) PL1663963T3 (de)
PT (1) PT1663963E (de)
SI (1) SI1663963T1 (de)
UA (1) UA85196C2 (de)
WO (1) WO2005028428A1 (de)
ZA (1) ZA200601962B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1516869A1 (de) * 2003-09-19 2005-03-23 Cephalon France Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1702915A1 (de) 2005-03-14 2006-09-20 Cephalon France Verfahren zur enantioselktiven Herstellung von einzelnen Enantiomeren von thio-substituierten Arylmethansulfinylderivaten durch asymetrische Oxidierung
CN1321978C (zh) * 2005-04-29 2007-06-20 浙江工业大学 一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007027328A2 (en) * 2005-07-28 2007-03-08 University Of Iowa Research Foundation Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
WO2007103221A2 (en) 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
US20080214862A1 (en) * 2006-12-06 2008-09-04 Ben-Zion Dolitzky Processes for preparing armodafinil intermediate
EP2155664A2 (de) * 2007-06-04 2010-02-24 Generics Ýuk¨Limited Neues verfahren
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
WO2009025791A2 (en) * 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
BR112012001078A8 (pt) * 2009-07-16 2016-05-03 Bayer Cropscience Ag Processo para preparação de derivados de sulfóxido de 3-triazolila quirais
KR20120101588A (ko) * 2010-01-07 2012-09-13 비버스 인크. 탄산탈수효소 억제제 및 추가적인 활성제의 조합에 의한 폐쇄 수면 무호흡 증후군의 치료
RU2448954C1 (ru) * 2010-10-18 2012-04-27 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения сульфоксидов
EP2649187B1 (de) 2010-12-08 2017-11-22 Codexis, Inc. Biokatalysatoren und verfahren zur synthese von armodafinil
FR2970711B1 (fr) * 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
RU2477316C1 (ru) * 2011-12-29 2013-03-10 Учреждение Российской академии наук Институт экологии и генетики микроорганизмов Уральского отделения РАН Биокаталитический способ получения (r)-фенилметилового сульфоксида
CN104447440B (zh) * 2013-09-12 2016-05-18 中国科学院大连化学物理研究所 一种催化不对称氧化硫醚的方法
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
EP2985279B1 (de) 2014-08-13 2017-08-02 Red Bull GmbH Heterocyclische Verbindungen mit Aktivität zur Arbeitsspeicherverbesserung
CA2989243C (en) 2014-08-13 2023-03-14 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098824A (en) * 1975-10-02 1978-07-04 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
KR20060024028A (ko) * 2000-07-27 2006-03-15 테바 파마슈티컬 인더스트리즈 리미티드 결정질의 순수한 모다피닐 및 이의 제조 방법
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (de) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Verfahren zur Herstellung von Methyl 2-Diphenylmethylsulfinylacetat
EP1516869A1 (de) * 2003-09-19 2005-03-23 Cephalon France Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung

Also Published As

Publication number Publication date
EP1516869A1 (de) 2005-03-23
DK1663963T3 (da) 2007-10-29
BRPI0414298B1 (pt) 2021-06-08
WO2005028428A1 (en) 2005-03-31
EA009385B1 (ru) 2007-12-28
PT1663963E (pt) 2007-10-19
JP2007505891A (ja) 2007-03-15
US7812193B2 (en) 2010-10-12
NZ545739A (en) 2010-01-29
BRPI0414298A (pt) 2006-11-14
AU2004274248B2 (en) 2010-08-26
DE602004007278T2 (de) 2008-02-28
ES2289556T3 (es) 2008-02-01
EP1663963B1 (de) 2007-06-27
US20080171896A1 (en) 2008-07-17
CA2538697A1 (en) 2005-03-31
KR101136703B1 (ko) 2012-05-24
JP4713480B2 (ja) 2011-06-29
CN100404502C (zh) 2008-07-23
EA200600593A1 (ru) 2006-08-25
AU2004274248A1 (en) 2005-03-31
KR20070009968A (ko) 2007-01-19
US7317126B2 (en) 2008-01-08
ATE365711T1 (de) 2007-07-15
MXPA06002935A (es) 2006-06-14
UA85196C2 (ru) 2009-01-12
SI1663963T1 (sl) 2007-12-31
CA2538697C (en) 2012-11-13
PL1663963T3 (pl) 2007-11-30
ZA200601962B (en) 2007-06-27
EP1663963A1 (de) 2006-06-07
US20050080256A1 (en) 2005-04-14
CN1867544A (zh) 2006-11-22

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