DK1663963T3 - Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation - Google Patents

Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation

Info

Publication number
DK1663963T3
DK1663963T3 DK04769402T DK04769402T DK1663963T3 DK 1663963 T3 DK1663963 T3 DK 1663963T3 DK 04769402 T DK04769402 T DK 04769402T DK 04769402 T DK04769402 T DK 04769402T DK 1663963 T3 DK1663963 T3 DK 1663963T3
Authority
DK
Denmark
Prior art keywords
modafinil
single enantiomers
enantioselective synthesis
formula
asymmetric oxidation
Prior art date
Application number
DK04769402T
Other languages
Danish (da)
English (en)
Inventor
Francois Rebiere
Gerard Duret
Laurence Prat
Original Assignee
Cephalon France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon France filed Critical Cephalon France
Application granted granted Critical
Publication of DK1663963T3 publication Critical patent/DK1663963T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DK04769402T 2003-09-19 2004-09-17 Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation DK1663963T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03292312A EP1516869A1 (de) 2003-09-19 2003-09-19 Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung
US50708903P 2003-10-01 2003-10-01
PCT/IB2004/003026 WO2005028428A1 (en) 2003-09-19 2004-09-17 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Publications (1)

Publication Number Publication Date
DK1663963T3 true DK1663963T3 (da) 2007-10-29

Family

ID=34178643

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04769402T DK1663963T3 (da) 2003-09-19 2004-09-17 Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation

Country Status (21)

Country Link
US (2) US7317126B2 (de)
EP (2) EP1516869A1 (de)
JP (1) JP4713480B2 (de)
KR (1) KR101136703B1 (de)
CN (1) CN100404502C (de)
AT (1) ATE365711T1 (de)
AU (1) AU2004274248B2 (de)
BR (1) BRPI0414298B1 (de)
CA (1) CA2538697C (de)
DE (1) DE602004007278T2 (de)
DK (1) DK1663963T3 (de)
EA (1) EA009385B1 (de)
ES (1) ES2289556T3 (de)
MX (1) MXPA06002935A (de)
NZ (1) NZ545739A (de)
PL (1) PL1663963T3 (de)
PT (1) PT1663963E (de)
SI (1) SI1663963T1 (de)
UA (1) UA85196C2 (de)
WO (1) WO2005028428A1 (de)
ZA (1) ZA200601962B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (de) * 2003-09-19 2005-03-23 Cephalon France Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung
EP1702915A1 (de) * 2005-03-14 2006-09-20 Cephalon France Verfahren zur enantioselktiven Herstellung von einzelnen Enantiomeren von thio-substituierten Arylmethansulfinylderivaten durch asymetrische Oxidierung
CN1321978C (zh) * 2005-04-29 2007-06-20 浙江工业大学 一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
US7553646B2 (en) * 2005-07-28 2009-06-30 University Of Iowa Research Foundation Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
MX2007012605A (es) * 2006-02-21 2008-01-11 Teva Pharma Formas cristalinas novedosas de armodafinil y preparacion de ellas.
EP2159219A3 (de) 2006-03-01 2010-12-15 Teva Pharmaceutical Industries Ltd. Verbessertes Verfahren zur Zubereitung von Armodafinil
WO2008070143A1 (en) * 2006-12-06 2008-06-12 Teva Pharmaceutical Industries Ltd. Processes for preparing armodafinil intermediate
WO2008149141A2 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
ES2525535T3 (es) * 2009-07-16 2014-12-26 Bayer Intellectual Property Gmbh Procedimiento para la preparación de derivados de 3-triazolil-sulfóxido quirales
KR20120101588A (ko) * 2010-01-07 2012-09-13 비버스 인크. 탄산탈수효소 억제제 및 추가적인 활성제의 조합에 의한 폐쇄 수면 무호흡 증후군의 치료
RU2448954C1 (ru) * 2010-10-18 2012-04-27 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения сульфоксидов
EP2649187B1 (de) 2010-12-08 2017-11-22 Codexis, Inc. Biokatalysatoren und verfahren zur synthese von armodafinil
FR2970711B1 (fr) * 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
RU2477316C1 (ru) * 2011-12-29 2013-03-10 Учреждение Российской академии наук Институт экологии и генетики микроорганизмов Уральского отделения РАН Биокаталитический способ получения (r)-фенилметилового сульфоксида
CN104447440B (zh) * 2013-09-12 2016-05-18 中国科学院大连化学物理研究所 一种催化不对称氧化硫醚的方法
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
WO2016023997A1 (en) 2014-08-13 2016-02-18 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
EP2985279B1 (de) 2014-08-13 2017-08-02 Red Bull GmbH Heterocyclische Verbindungen mit Aktivität zur Arbeitsspeicherverbesserung
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127722A (en) * 1975-10-02 1978-11-28 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
EP2168946A1 (de) * 2000-07-27 2010-03-31 Teva Pharmaceutical Industries Ltd Kirstalline Form von Modafinil und Verfahren zu deren Herstellung
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (de) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Verfahren zur Herstellung von Methyl 2-Diphenylmethylsulfinylacetat
EP1516869A1 (de) * 2003-09-19 2005-03-23 Cephalon France Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung

Also Published As

Publication number Publication date
EP1663963A1 (de) 2006-06-07
DE602004007278D1 (de) 2007-08-09
ATE365711T1 (de) 2007-07-15
EA009385B1 (ru) 2007-12-28
US7812193B2 (en) 2010-10-12
CN100404502C (zh) 2008-07-23
JP2007505891A (ja) 2007-03-15
US20050080256A1 (en) 2005-04-14
BRPI0414298B1 (pt) 2021-06-08
AU2004274248A1 (en) 2005-03-31
EA200600593A1 (ru) 2006-08-25
ZA200601962B (en) 2007-06-27
PT1663963E (pt) 2007-10-19
NZ545739A (en) 2010-01-29
CA2538697A1 (en) 2005-03-31
KR101136703B1 (ko) 2012-05-24
UA85196C2 (ru) 2009-01-12
EP1663963B1 (de) 2007-06-27
KR20070009968A (ko) 2007-01-19
SI1663963T1 (sl) 2007-12-31
DE602004007278T2 (de) 2008-02-28
WO2005028428A1 (en) 2005-03-31
CN1867544A (zh) 2006-11-22
JP4713480B2 (ja) 2011-06-29
PL1663963T3 (pl) 2007-11-30
EP1516869A1 (de) 2005-03-23
CA2538697C (en) 2012-11-13
AU2004274248B2 (en) 2010-08-26
ES2289556T3 (es) 2008-02-01
US20080171896A1 (en) 2008-07-17
MXPA06002935A (es) 2006-06-14
US7317126B2 (en) 2008-01-08
BRPI0414298A (pt) 2006-11-14

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