ATE460395T1 - Ein verfahren zur herstellung von bicalutamid - Google Patents
Ein verfahren zur herstellung von bicalutamidInfo
- Publication number
- ATE460395T1 ATE460395T1 AT06254847T AT06254847T ATE460395T1 AT E460395 T1 ATE460395 T1 AT E460395T1 AT 06254847 T AT06254847 T AT 06254847T AT 06254847 T AT06254847 T AT 06254847T AT E460395 T1 ATE460395 T1 AT E460395T1
- Authority
- AT
- Austria
- Prior art keywords
- bicalutamid
- producing
- formula
- water
- bicalutamide
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 abstract 2
- 229960000997 bicalutamide Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1187KO2005 | 2005-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460395T1 true ATE460395T1 (de) | 2010-03-15 |
Family
ID=38115978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06254847T ATE460395T1 (de) | 2005-12-27 | 2006-09-19 | Ein verfahren zur herstellung von bicalutamid |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7544828B2 (de) |
| EP (1) | EP1803707B1 (de) |
| AT (1) | ATE460395T1 (de) |
| AU (1) | AU2006329551A1 (de) |
| CA (1) | CA2635461A1 (de) |
| DE (1) | DE602006012792D1 (de) |
| WO (1) | WO2007074473A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070114343A (ko) * | 2005-03-29 | 2007-12-03 | 유에스브이 리미티드 | 비칼루타미드의 제조 방법 |
| CA2513356A1 (en) * | 2005-07-26 | 2007-01-26 | Apotex Pharmachem Inc. | Process for production of bicalutamide |
| WO2009087666A2 (en) * | 2008-01-04 | 2009-07-16 | Kekule Pharma | An improved process for production of bicalutamide useful in the treatment of prostate cancer |
| CN102321000A (zh) * | 2011-07-21 | 2012-01-18 | 宁波人健药业集团有限公司 | 氧化制备比卡鲁胺的方法 |
| CN102351762A (zh) * | 2011-07-21 | 2012-02-15 | 宁波人健药业集团有限公司 | 用n-(4-氰基-3-三氟甲基苯基)-3-(4-氟苯硫基)-2-甲基-2-羟基丙酰胺制备比卡鲁胺的方法 |
| JP6151723B2 (ja) * | 2012-02-27 | 2017-06-21 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | ３−メチルスルホニルプロピオニトリルを調製するプロセス |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU88769I2 (fr) * | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| HU223950B1 (hu) * | 1999-06-10 | 2005-03-29 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására |
| EP1322603A1 (de) * | 2000-09-21 | 2003-07-02 | Bristol-Myers Squibb Company | Verfahren zur herstellung von n-(substituiertes phenyl)-3-alkyl-, aryl- und heteroarylsulfonyl-2-hydroxy-2-alkyl- und haloalkylpropanamid verbindungen |
| KR100938188B1 (ko) * | 2001-12-13 | 2010-01-21 | 스미또모 가가꾸 가부시키가이샤 | 비칼루타미드의 결정 및 그 제조 방법 |
| CN1458146A (zh) * | 2002-05-15 | 2003-11-26 | 中国科学院上海药物研究所 | 抗肿瘤药物比卡鲁胺合成工艺 |
| US7146050B2 (en) * | 2002-07-19 | 2006-12-05 | Intel Corporation | Facial classification of static images using support vector machines |
| US20040063782A1 (en) * | 2002-09-27 | 2004-04-01 | Westheim Raymond J.H. | Bicalutamide forms |
| WO2004074350A2 (en) | 2003-02-21 | 2004-09-02 | Hetero Drugs Limited | Bicalutamide polymorphs |
| JP4322621B2 (ja) | 2003-10-16 | 2009-09-02 | 住友化学株式会社 | ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法 |
-
2006
- 2006-09-15 AU AU2006329551A patent/AU2006329551A1/en not_active Abandoned
- 2006-09-15 CA CA002635461A patent/CA2635461A1/en not_active Abandoned
- 2006-09-15 WO PCT/IN2006/000378 patent/WO2007074473A1/en active Application Filing
- 2006-09-19 DE DE602006012792T patent/DE602006012792D1/de active Active
- 2006-09-19 AT AT06254847T patent/ATE460395T1/de not_active IP Right Cessation
- 2006-09-19 EP EP06254847A patent/EP1803707B1/de not_active Not-in-force
- 2006-10-17 US US11/582,716 patent/US7544828B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7544828B2 (en) | 2009-06-09 |
| EP1803707B1 (de) | 2010-03-10 |
| AU2006329551A1 (en) | 2007-07-05 |
| US20070149800A1 (en) | 2007-06-28 |
| EP1803707A1 (de) | 2007-07-04 |
| CA2635461A1 (en) | 2007-07-05 |
| WO2007074473A1 (en) | 2007-07-05 |
| DE602006012792D1 (de) | 2010-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |