DE60132596T2 - NUKLEINSÄUREBINDENDE VERBINDUNGEN MIT PYRAZOLOi3,4-D PYRIMIDINANALOGEN VON PURIN-2,6-DIAMIN UND IHRE VERWENDUNG - Google Patents
NUKLEINSÄUREBINDENDE VERBINDUNGEN MIT PYRAZOLOi3,4-D PYRIMIDINANALOGEN VON PURIN-2,6-DIAMIN UND IHRE VERWENDUNG Download PDFInfo
- Publication number
- DE60132596T2 DE60132596T2 DE60132596T DE60132596T DE60132596T2 DE 60132596 T2 DE60132596 T2 DE 60132596T2 DE 60132596 T DE60132596 T DE 60132596T DE 60132596 T DE60132596 T DE 60132596T DE 60132596 T2 DE60132596 T2 DE 60132596T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- nucleic acid
- alkyl
- independently
- acid binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CC(C1C)[C@](CO*)O[C@]1S Chemical compound CC(C1C)[C@](CO*)O[C@]1S 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00116816 | 2000-08-03 | ||
| EP00116816 | 2000-08-03 | ||
| EP01109438 | 2001-04-24 | ||
| EP01109438 | 2001-04-24 | ||
| PCT/EP2001/008850 WO2002012263A1 (en) | 2000-08-03 | 2001-07-31 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132596D1 DE60132596D1 (de) | 2008-03-13 |
| DE60132596T2 true DE60132596T2 (de) | 2009-02-19 |
Family
ID=26071249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132596T Expired - Lifetime DE60132596T2 (de) | 2000-08-03 | 2001-07-31 | NUKLEINSÄUREBINDENDE VERBINDUNGEN MIT PYRAZOLOi3,4-D PYRIMIDINANALOGEN VON PURIN-2,6-DIAMIN UND IHRE VERWENDUNG |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7238795B2 (enExample) |
| EP (1) | EP1307469B1 (enExample) |
| JP (1) | JP4331476B2 (enExample) |
| AT (1) | ATE384731T1 (enExample) |
| AU (1) | AU2001278517A1 (enExample) |
| CA (1) | CA2416631C (enExample) |
| DE (1) | DE60132596T2 (enExample) |
| ES (1) | ES2300346T3 (enExample) |
| WO (1) | WO2002012263A1 (enExample) |
Families Citing this family (72)
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| CA2557818A1 (en) * | 2004-03-03 | 2005-09-15 | The Trustees Of Columbia University In The City Of New York | Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry |
| CN101056991A (zh) * | 2004-04-20 | 2007-10-17 | 基因耐克生物医学制品有限公司 | 检测ncRNA的方法 |
| WO2006073436A2 (en) * | 2004-04-29 | 2006-07-13 | The Trustees Of Columbia University In The City Of New York | Mass tag pcr for multiplex diagnostics |
| EP1746099A1 (en) * | 2004-12-23 | 2007-01-24 | DeveloGen Aktiengesellschaft | Mnk1 or Mnk2 inhibitors |
| WO2007002204A2 (en) | 2005-06-21 | 2007-01-04 | The Trustees Of Columbia University In The City Of New York | Pyrosequencing methods and related compostions |
| US7642086B2 (en) * | 2005-08-09 | 2010-01-05 | Canon Kabushiki Kaisha | Labeled probe bound object, method for producing the same and method for using the same |
| CA2630544A1 (en) * | 2005-11-21 | 2007-05-31 | The Trustees Of Columbia University In The City Of New York | Multiplex digital immuno-sensing using a library of photocleavable mass tags |
| US8889348B2 (en) | 2006-06-07 | 2014-11-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by nanopore using modified nucleotides |
| US7772390B1 (en) | 2006-07-18 | 2010-08-10 | The Regents Of The University Of California | Lipid mediated nucleic acid synthesis |
| DE112007002932B4 (de) | 2006-12-01 | 2015-08-06 | The Trustees Of Columbia University In The City Of New York | Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren |
| US8535888B2 (en) | 2006-12-29 | 2013-09-17 | Mayo Foundation For Medical Education And Research | Compositions and methods for detecting methicillin-resistant S. aureus |
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| WO2009023733A1 (en) * | 2007-08-13 | 2009-02-19 | Trustees Of Tufts College | Methods and microarrays for detecting enteric viruses |
| EP4310194A3 (en) | 2007-10-19 | 2024-10-16 | The Trustees of Columbia University in the City of New York | Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis |
| US9115163B2 (en) | 2007-10-19 | 2015-08-25 | The Trustees Of Columbia University In The City Of New York | DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators |
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| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
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| CA2802567C (en) | 2010-07-29 | 2017-12-05 | F. Hoffmann La-Roche Ag | Control nucleic acids for multiple parameters |
| CA2802548C (en) | 2010-07-29 | 2017-01-03 | F. Hoffmann-La Roche Ag | Qualitative and quantitative detection of microbial nucleic acids |
| CN103270171B (zh) | 2010-07-29 | 2014-09-17 | 霍夫曼-拉罗奇有限公司 | 通用pcr |
| DE112011102524T5 (de) | 2010-07-29 | 2013-07-11 | Roche Diagnostics Gmbh | Präparation generischer Proben |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| EP2652153B1 (en) | 2010-12-17 | 2017-07-05 | The Trustees of Columbia University in the City of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| EP2465945A1 (en) | 2010-12-17 | 2012-06-20 | F. Hoffmann-La Roche AG | Generic matrix for control nucleic acids |
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| EP2495336B8 (en) * | 2011-03-04 | 2014-07-23 | Roche Diagnostics GmbH | A new type of universal probes for the detection of genomic variants |
| US9624539B2 (en) | 2011-05-23 | 2017-04-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using Raman and infrared spectroscopy detection |
| WO2013013068A2 (en) | 2011-07-19 | 2013-01-24 | University Of Idaho | Embodiments of a probe and method for targeting nucleic acids |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| EP2776450B1 (en) | 2011-11-10 | 2018-04-04 | Shire Human Genetic Therapies, Inc. | Antisense oligonucleotide modulators of serotonin receptor 2c and uses thereof |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| US10246479B2 (en) | 2012-04-09 | 2019-04-02 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
| GB2510719A (en) | 2012-06-15 | 2014-08-13 | Genia Technologies Inc | Chip set-up and high-accuracy nucleic acid sequencing |
| EP2864502B1 (en) | 2012-06-20 | 2019-10-23 | The Trustees of Columbia University in the City of New York | Nucleic acid sequencing by nanopore detection of tag molecules |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
| US10648026B2 (en) | 2013-03-15 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
| EP3640349A3 (en) | 2013-10-23 | 2020-07-29 | Roche Sequencing Solutions, Inc. | High speed molecular sensing with nanopores |
| US9322062B2 (en) | 2013-10-23 | 2016-04-26 | Genia Technologies, Inc. | Process for biosensor well formation |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| CA2943952A1 (en) | 2014-03-24 | 2015-10-01 | The Trustees Of Columbia University In The City Of New York | Chemical methods for producing tagged nucleotides |
| CN104910229B (zh) * | 2015-04-30 | 2019-11-12 | 赛纳生物科技(北京)有限公司 | 多聚磷酸末端荧光标记核苷酸及其应用 |
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| US11078534B2 (en) | 2017-11-27 | 2021-08-03 | Roche Molecular Systems, Inc. | Photocleavable nucleotide reagents with high stability |
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-
2001
- 2001-07-31 EP EP01956576A patent/EP1307469B1/en not_active Expired - Lifetime
- 2001-07-31 AT AT01956576T patent/ATE384731T1/de active
- 2001-07-31 AU AU2001278517A patent/AU2001278517A1/en not_active Abandoned
- 2001-07-31 WO PCT/EP2001/008850 patent/WO2002012263A1/en not_active Ceased
- 2001-07-31 ES ES01956576T patent/ES2300346T3/es not_active Expired - Lifetime
- 2001-07-31 CA CA2416631A patent/CA2416631C/en not_active Expired - Lifetime
- 2001-07-31 US US10/333,518 patent/US7238795B2/en not_active Expired - Lifetime
- 2001-07-31 JP JP2002518237A patent/JP4331476B2/ja not_active Expired - Lifetime
- 2001-07-31 DE DE60132596T patent/DE60132596T2/de not_active Expired - Lifetime
-
2007
- 2007-04-30 US US11/742,416 patent/US8057997B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4331476B2 (ja) | 2009-09-16 |
| EP1307469B1 (en) | 2008-01-23 |
| EP1307469A1 (en) | 2003-05-07 |
| ATE384731T1 (de) | 2008-02-15 |
| CA2416631A1 (en) | 2002-02-14 |
| DE60132596D1 (de) | 2008-03-13 |
| US7238795B2 (en) | 2007-07-03 |
| US8057997B2 (en) | 2011-11-15 |
| AU2001278517A1 (en) | 2002-02-18 |
| US20110021365A1 (en) | 2011-01-27 |
| WO2002012263A1 (en) | 2002-02-14 |
| CA2416631C (en) | 2011-11-22 |
| JP2004505988A (ja) | 2004-02-26 |
| ES2300346T3 (es) | 2008-06-16 |
| US20030198982A1 (en) | 2003-10-23 |
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