DE60129965T2 - Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system - Google Patents
Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system Download PDFInfo
- Publication number
- DE60129965T2 DE60129965T2 DE60129965T DE60129965T DE60129965T2 DE 60129965 T2 DE60129965 T2 DE 60129965T2 DE 60129965 T DE60129965 T DE 60129965T DE 60129965 T DE60129965 T DE 60129965T DE 60129965 T2 DE60129965 T2 DE 60129965T2
- Authority
- DE
- Germany
- Prior art keywords
- electrode
- reservoir
- reservoir electrode
- polymeric material
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003860 storage Methods 0.000 title description 22
- 239000000463 material Substances 0.000 claims abstract description 64
- 239000000853 adhesive Substances 0.000 claims abstract description 19
- 230000001070 adhesive effect Effects 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 229910001514 alkali metal chloride Inorganic materials 0.000 claims abstract description 5
- 150000003841 chloride salts Chemical class 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 57
- 229940079593 drug Drugs 0.000 claims description 52
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 32
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 24
- 230000007797 corrosion Effects 0.000 claims description 20
- 238000005260 corrosion Methods 0.000 claims description 20
- 230000002745 absorbent Effects 0.000 claims description 18
- 239000002250 absorbent Substances 0.000 claims description 18
- 239000000017 hydrogel Substances 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 239000004332 silver Substances 0.000 claims description 13
- -1 alkali metal halide salt Chemical class 0.000 claims description 12
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims description 12
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 11
- 229910052709 silver Inorganic materials 0.000 claims description 11
- YLXIPWWIOISBDD-NDAAPVSOSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CNC[C@H](O)C1=CC=C(O)C(O)=C1 YLXIPWWIOISBDD-NDAAPVSOSA-N 0.000 claims description 10
- 229960003157 epinephrine bitartrate Drugs 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000012458 free base Substances 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000006870 function Effects 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 229960004106 citric acid Drugs 0.000 claims description 2
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- 239000011243 crosslinked material Substances 0.000 claims 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000004026 adhesive bonding Methods 0.000 claims 1
- 229910001508 alkali metal halide Inorganic materials 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- RMGVZKRVHHSUIM-UHFFFAOYSA-L dithionate(2-) Chemical compound [O-]S(=O)(=O)S([O-])(=O)=O RMGVZKRVHHSUIM-UHFFFAOYSA-L 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 abstract 2
- 238000004132 cross linking Methods 0.000 description 18
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 10
- 229910052783 alkali metal Inorganic materials 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000005865 ionizing radiation Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000012377 drug delivery Methods 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 4
- 229930182837 (R)-adrenaline Natural products 0.000 description 4
- HYKGUEIYMKVUSR-NPULLEENSA-N 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C HYKGUEIYMKVUSR-NPULLEENSA-N 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 238000010894 electron beam technology Methods 0.000 description 4
- 229960005139 epinephrine Drugs 0.000 description 4
- 230000002787 reinforcement Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000013065 commercial product Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 239000007772 electrode material Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000003411 electrode reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000010416 ion conductor Substances 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/610,563 US6629968B1 (en) | 2000-06-30 | 2000-06-30 | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode |
| US610563 | 2000-06-30 | ||
| PCT/US2001/020886 WO2002002182A2 (en) | 2000-06-30 | 2001-06-29 | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60129965D1 DE60129965D1 (de) | 2007-09-27 |
| DE60129965T2 true DE60129965T2 (de) | 2008-05-15 |
Family
ID=24445534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60129965T Expired - Lifetime DE60129965T2 (de) | 2000-06-30 | 2001-06-29 | Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6629968B1 (enExample) |
| EP (1) | EP1294439B1 (enExample) |
| JP (1) | JP4024673B2 (enExample) |
| AT (1) | ATE369891T1 (enExample) |
| AU (1) | AU2001273104A1 (enExample) |
| CA (1) | CA2413624C (enExample) |
| DE (1) | DE60129965T2 (enExample) |
| WO (1) | WO2002002182A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6757560B1 (en) * | 1999-04-09 | 2004-06-29 | Novosis Pharma Ag | Transdermal delivery system (TDS) with electrode network |
| JP4033382B2 (ja) * | 2002-04-08 | 2008-01-16 | 久光製薬株式会社 | インスリン投与装置 |
| US7776600B2 (en) | 2002-04-18 | 2010-08-17 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
| WO2003088925A2 (en) | 2002-04-18 | 2003-10-30 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
| JP4089875B2 (ja) * | 2002-06-12 | 2008-05-28 | 共同印刷株式会社 | 凹部を含む電極装置 |
| JP3493359B1 (ja) * | 2003-03-20 | 2004-02-03 | 宣美 辛島 | イオン泳動式治療装置 |
| US7917205B2 (en) * | 2003-03-20 | 2011-03-29 | Nobuyoshi Karashima | Iontophoresis-based medical device |
| EP1608433B1 (en) * | 2003-03-31 | 2009-03-11 | ALZA Corporation | Electrotransport device having a reservoir housing having a flexible conductive element |
| JPWO2005020967A1 (ja) * | 2003-08-29 | 2007-11-01 | 久光製薬株式会社 | 電気的薬物移送製剤 |
| US20100016929A1 (en) * | 2004-01-22 | 2010-01-21 | Arthur Prochazka | Method and system for controlled nerve ablation |
| EP1706178B1 (en) | 2004-01-22 | 2013-04-24 | Rehabtronics Inc. | System for routing electrical current to bodily tissues via implanted passive conductors |
| US20050234516A1 (en) * | 2004-02-16 | 2005-10-20 | Gueret Jean-Louis H | Treatment kit, composite structure, electric exciter, and cosmetic treatment method |
| FR2866240B1 (fr) * | 2004-02-16 | 2006-06-23 | Oreal | Kit de traitement comportant une structure composite a appliquer sur la peau et un excitateur electrique |
| US20050228335A1 (en) * | 2004-04-07 | 2005-10-13 | Reddy Vilambi N | Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems |
| US20050228336A1 (en) * | 2004-04-07 | 2005-10-13 | Preston Keusch | Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability |
| WO2006015299A2 (en) * | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| JP4728631B2 (ja) * | 2004-11-30 | 2011-07-20 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| US7590444B2 (en) * | 2004-12-09 | 2009-09-15 | Tti Ellebeau, Inc. | Iontophoresis device |
| JP4731931B2 (ja) * | 2005-02-03 | 2011-07-27 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| JP4793806B2 (ja) * | 2005-03-22 | 2011-10-12 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| US8386029B2 (en) | 2005-03-31 | 2013-02-26 | Encore Medical Asset Corporation | Apparatus for electrotherapy drug delivery with added impurities |
| US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
| US8386030B2 (en) | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
| US8295922B2 (en) | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
| US20070088331A1 (en) * | 2005-08-18 | 2007-04-19 | Transcutaneous Technologies Inc. | Method and apparatus for managing active agent usage, and active agent injecting device |
| KR20080047600A (ko) | 2005-09-15 | 2008-05-29 | 티티아이 엘뷰 가부시키가이샤 | 로드형 이온토포레시스 장치 |
| US20070078372A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia |
| US20070083147A1 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
| US7574256B2 (en) | 2005-09-30 | 2009-08-11 | Tti Ellebeau, Inc. | Iontophoretic device and method of delivery of active agents to biological interface |
| US20070093788A1 (en) * | 2005-09-30 | 2007-04-26 | Darrick Carter | Iontophoresis method and apparatus for systemic delivery of active agents |
| WO2007041158A1 (en) * | 2005-09-30 | 2007-04-12 | Vyteris, Inc. | Iontophoresis drug delivery device providing acceptable depth and duration of dermal anesthesia |
| EP1928543A2 (en) * | 2005-09-30 | 2008-06-11 | Vyteris, Inc. | Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch |
| US20070078434A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices |
| JP5116482B2 (ja) * | 2005-11-14 | 2013-01-09 | 帝國製薬株式会社 | イオントフォレーシス用製剤 |
| WO2007079193A2 (en) | 2005-12-30 | 2007-07-12 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
| US8483820B2 (en) * | 2006-10-05 | 2013-07-09 | Bioness Inc. | System and method for percutaneous delivery of electrical stimulation to a target body tissue |
| WO2008067409A2 (en) * | 2006-11-28 | 2008-06-05 | Polyplus Battery Company | Protected lithium electrodes for electro-transport drug delivery |
| US8062783B2 (en) | 2006-12-01 | 2011-11-22 | Tti Ellebeau, Inc. | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| WO2008087803A1 (ja) * | 2007-01-16 | 2008-07-24 | Hokkaido University | 抗酸化成分を封入したイオントフォレーシス用リポソーム製剤 |
| US7844345B2 (en) * | 2007-02-08 | 2010-11-30 | Neuropace, Inc. | Drug eluting lead systems |
| US7813811B2 (en) * | 2007-02-08 | 2010-10-12 | Neuropace, Inc. | Refillable reservoir lead systems |
| WO2008101171A2 (en) * | 2007-02-16 | 2008-08-21 | Thermage, Inc. | Temperature sensing apparatus and methods for treatment devices used to deliver high frequency energy to tissue |
| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| WO2009006349A2 (en) * | 2007-06-29 | 2009-01-08 | Polyplus Battery Company | Electrotransport devices, methods and drug electrode assemblies |
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-
2000
- 2000-06-30 US US09/610,563 patent/US6629968B1/en not_active Expired - Fee Related
-
2001
- 2001-06-29 EP EP01952340A patent/EP1294439B1/en not_active Expired - Lifetime
- 2001-06-29 AU AU2001273104A patent/AU2001273104A1/en not_active Abandoned
- 2001-06-29 JP JP2002506803A patent/JP4024673B2/ja not_active Expired - Fee Related
- 2001-06-29 CA CA002413624A patent/CA2413624C/en not_active Expired - Fee Related
- 2001-06-29 WO PCT/US2001/020886 patent/WO2002002182A2/en not_active Ceased
- 2001-06-29 US US09/897,698 patent/US6635045B2/en not_active Expired - Fee Related
- 2001-06-29 AT AT01952340T patent/ATE369891T1/de not_active IP Right Cessation
- 2001-06-29 DE DE60129965T patent/DE60129965T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1294439A2 (en) | 2003-03-26 |
| ATE369891T1 (de) | 2007-09-15 |
| DE60129965D1 (de) | 2007-09-27 |
| JP4024673B2 (ja) | 2007-12-19 |
| JP2004501727A (ja) | 2004-01-22 |
| CA2413624A1 (en) | 2002-01-10 |
| EP1294439B1 (en) | 2007-08-15 |
| US20020062102A1 (en) | 2002-05-23 |
| AU2001273104A1 (en) | 2002-01-14 |
| WO2002002182A2 (en) | 2002-01-10 |
| US6635045B2 (en) | 2003-10-21 |
| CA2413624C (en) | 2007-09-18 |
| WO2002002182A3 (en) | 2002-06-27 |
| US6629968B1 (en) | 2003-10-07 |
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