DE60111393D1 - Biphenylderivate und ihre verwendung als aktivatoren des ppar-gamma-rezeptors - Google Patents

Biphenylderivate und ihre verwendung als aktivatoren des ppar-gamma-rezeptors

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Publication number
DE60111393D1
DE60111393D1 DE60111393T DE60111393T DE60111393D1 DE 60111393 D1 DE60111393 D1 DE 60111393D1 DE 60111393 T DE60111393 T DE 60111393T DE 60111393 T DE60111393 T DE 60111393T DE 60111393 D1 DE60111393 D1 DE 60111393D1
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DE
Germany
Prior art keywords
activators
gamma receptor
ppar gamma
biphenyl derivatives
biphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60111393T
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English (en)
Other versions
DE60111393T2 (de
Inventor
Jean-Michel Bernardon
Laurence Clary
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Galderma Research and Development SNC
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Galderma Research and Development SNC
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Publication of DE60111393D1 publication Critical patent/DE60111393D1/de
Publication of DE60111393T2 publication Critical patent/DE60111393T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D207/36—Oxygen or sulfur atoms
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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60111393T 2000-08-08 2001-08-03 Biphenylderivate und ihre Verwendung als Aktivatoren der PPAR-Gamma-Rezeptoren Expired - Lifetime DE60111393T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0010447A FR2812876B1 (fr) 2000-08-08 2000-08-08 Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
FR0010447 2000-08-08
PCT/FR2001/002543 WO2002012210A1 (fr) 2000-08-08 2001-08-03 Derives de biphenyle et leur utilisation comme activateurs des recepteurs ppar-gamma

Publications (2)

Publication Number Publication Date
DE60111393D1 true DE60111393D1 (de) 2005-07-14
DE60111393T2 DE60111393T2 (de) 2006-03-23

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DE60111393T Expired - Lifetime DE60111393T2 (de) 2000-08-08 2001-08-03 Biphenylderivate und ihre Verwendung als Aktivatoren der PPAR-Gamma-Rezeptoren

Country Status (20)

Country Link
US (1) US6927228B2 (de)
EP (1) EP1309575B1 (de)
JP (1) JP2004505958A (de)
KR (1) KR20030051611A (de)
CN (1) CN1468226A (de)
AR (1) AR032888A1 (de)
AT (1) ATE297386T1 (de)
AU (2) AU8598101A (de)
BR (1) BR0113251A (de)
CA (1) CA2418895A1 (de)
DE (1) DE60111393T2 (de)
DK (1) DK1309575T3 (de)
ES (1) ES2245373T3 (de)
FR (1) FR2812876B1 (de)
MX (1) MXPA03001184A (de)
PL (1) PL360292A1 (de)
PT (1) PT1309575E (de)
RU (1) RU2280033C2 (de)
WO (1) WO2002012210A1 (de)
ZA (1) ZA200300667B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6949900A (en) 1999-08-31 2001-03-26 Maxia Pharmaceuticals, Inc. Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
PL373912A1 (en) * 2001-03-07 2005-09-19 Incyte San Diego, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
WO2002072543A2 (en) 2001-03-08 2002-09-19 Maxia Pharmaceuticals, Inc. Rxr activating molecules
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
US20040152746A1 (en) * 2001-04-30 2004-08-05 Bardsley Hazel Judith Treatment of scarring and related conditions using ppar-gamma activators
WO2002098840A1 (en) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
EP1421061A4 (de) * 2001-08-17 2004-12-22 Incyte San Diego Inc Oximderivate für die behandlung von dyslipidämie und hypercholesterinämie
AU2002352706A1 (en) 2001-11-15 2003-06-10 Maxia Pharmaceuticals, Inc. N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
AU2002351732A1 (en) 2001-12-14 2003-06-30 Novo Nordisk A/S Compositions decreasing activity of hormone-sensitive lipase
FR2836683B1 (fr) * 2002-03-01 2006-06-23 Galderma Res & Dev NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
FR2833949B1 (fr) * 2001-12-21 2005-08-05 Galderma Res & Dev NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
US6908939B2 (en) 2001-12-21 2005-06-21 Galderma Research & Development S.N.C. Biaromatic ligand activators of PPARγ receptors
US7196108B2 (en) 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
CN100408556C (zh) * 2002-10-07 2008-08-06 加利福尼亚大学董事会 通过阻断花生四烯酰乙醇酰胺的水解调节焦虑
CN1705645A (zh) * 2002-10-24 2005-12-07 默克专利有限公司 作为raf－激酶抑制剂的亚甲基脲衍生物
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
MXPA05005171A (es) * 2002-11-19 2005-10-26 Galderma Res & Dev Compuestos bi-aromaticos activadores de los receptores de tipo ppar-gama y su uso en composiciones cosmeticas o farmaceuticas.
FR2847251B1 (fr) * 2002-11-19 2006-11-17 NOUVEAUX COMPOSES BI-AROMATIQUES ACTIVEURS DES RECEPTEURS DE TYPE PPARy ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES
FR2847580B1 (fr) * 2002-11-25 2006-03-03 Galderma Res & Dev NOUVEAUX COMPOSES BI-AROMATIQUES ACTIVATEURS DES RECEPTEURS DE TYPE PPARy ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES
AU2003294025A1 (en) * 2002-11-25 2004-06-18 Galderma Research & Development, S.N.C. Biphenyl compounds which activate PPAR-gamma type receptors and use thereof in cosmetic or pharmaceutical compositions
BR0316193A (pt) 2002-12-12 2005-09-27 Galderma Res & Dev Composto, composição cosmética, uso cosmético de uma composição, uso de um composto e composição farmacêutica
FR2848553B1 (fr) * 2002-12-12 2007-03-30 Galderma Res & Dev Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
RU2005135850A (ru) * 2003-04-18 2006-06-10 Инсайт Сан Диего Инкорпорейтед (Us) Замещенные изохромановые соединения для лечения метаболических расстройств, рака и другие заболеваний
FR2856401B1 (fr) * 2003-06-20 2010-02-12 Galderma Res & Dev Nouveaux composes modulateurs des recepteurs de type ppargamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
MXPA05013645A (es) * 2003-06-20 2006-02-24 Galderma Res & Dev Nuevos compuestos moduladores de los receptores de tipo ppar gama y su utilizacion en composiciones cosmeticas o farmaceuticas.
FR2869903B1 (fr) * 2004-05-06 2006-06-23 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques
DE602005019555D1 (de) 2004-05-06 2010-04-08 Galderma Res & Dev Biaromatische verbindungen, die rezeptoren des typs ppar(gamma) aktivieren, verfahren zu deren herstellung und deren verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
KR100619441B1 (ko) * 2004-06-30 2006-09-08 서울옵토디바이스주식회사 기판제거가 용이한 질화갈륨 성장 방법
ES2315909T3 (es) * 2004-08-17 2009-04-01 GALDERMA RESEARCH & DEVELOPMENT Nuevos compuestos bioaromaticos que son activadores de los receptores del tipo ppar y su utilizacion en composiciones cosmeticas y farmaceuticas.
MX2007001942A (es) 2004-08-17 2007-05-09 Galderma Res & Dev Nuevos compuestos biaromaticos activadores de los receptores del tipo receptor activado del proliferador de peroxisoma (ppar) y su uso en composiciones cosmeticas o farmaceuticas.
FR2874378B1 (fr) * 2004-08-17 2006-10-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
FR2874379B1 (fr) * 2004-08-17 2006-10-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
KR20070085997A (ko) * 2004-11-19 2007-08-27 갈데르마 리써어치 앤드 디벨로프먼트 ＰＰＡＲγ 유형 수용체를 조정하는 화합물, 및 미용 또는약학 조성물에서의 이의 용도
FR2878247B1 (fr) 2004-11-19 2008-10-03 Galderma Res & Dev Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
RU2458919C2 (ru) 2005-04-13 2012-08-20 Астекс Терапьютикс Лимитед ПРОИЗВОДНЫЕ ГИДРОКСИБЕНЗАМИДА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90
US20070059265A1 (en) * 2005-06-28 2007-03-15 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers
FR2887444A1 (fr) * 2005-06-28 2006-12-29 Oreal Composes benzylidene-1,3-thiazolidine-2,4-diones, leurs utilisations et compositions pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute et/ou augmenter leur densite.
MX2007016374A (es) * 2005-06-30 2008-03-05 Novo Nordisk As Acidos fenoxiaceticos como activadores ppar delta.
FR2892412B1 (fr) * 2005-10-26 2008-05-16 Galderma Res & Dev Composes biaromatiques modulateurs des ppars
FR2897536A1 (fr) * 2006-02-17 2007-08-24 Galderma Res & Dev Utilisation du muraglitazar pour la preparation d'une composition pharmaceutique destinee au traitement des affections dermatologiques
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
WO2008042892A2 (en) * 2006-10-02 2008-04-10 N.V. Organon Fatty acid amide hydrolase inhibitors for energy metabolism disorders
EP2073802A1 (de) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmazeutische kombinationen
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
US7803940B2 (en) 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
FR2917086B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
WO2009058298A1 (en) 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CA2721615A1 (en) * 2008-04-15 2009-10-22 Burnham Institute For Medical Research An inhibitor of anti-apoptotic proteins
EP2310385B1 (de) 2008-07-31 2017-06-07 Takeda Pharmaceutical Company Limited Aus feststoffen bestehende pharmazeutische zusammensetzung
US20100158829A1 (en) * 2008-12-24 2010-06-24 Conopco, Inc., D/B/A Unilever Method and Composition for Color Modulation
CA2750710C (en) 2009-01-30 2018-09-04 Takeda Pharmaceutical Company Limited Fused ring compound and use thereof
FR2969149B1 (fr) * 2010-12-16 2012-12-28 Oreal Procede de depigmentation des matieres keratiniques a l' aide de composes derives de resorcinol
CN103857657B (zh) 2011-08-18 2016-04-20 日本新药株式会社 杂环衍生物及医药
KR101485247B1 (ko) * 2012-06-26 2015-01-22 중앙대학교 산학협력단 신규 바이페닐―３―카르복스아마이드 유도체 또는 이의 염 및 이를 유효성분으로 함유하는 자가 면역질환 치료 또는 예방용 약학조성물
MX385777B (es) * 2014-12-24 2025-03-04 Lg Chemical Ltd Derivado de biarilo como agonista de gpr120.
CN118184545B (zh) * 2023-03-22 2025-12-30 沈阳药科大学 一种化合物及其制备方法和在制备sEH抑制剂与PPARs激动剂中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046232A1 (en) * 1998-03-10 1999-09-16 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
WO2003018011A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-(substituted)-5-(substitutedsulfonyl or sulfanyl)thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase

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ZA200300667B (en) 2004-02-11
AR032888A1 (es) 2003-12-03
AU2001285981B2 (en) 2006-01-19
MXPA03001184A (es) 2003-10-15
US6927228B2 (en) 2005-08-09
AU8598101A (en) 2002-02-18
EP1309575A1 (de) 2003-05-14
BR0113251A (pt) 2003-06-24
ATE297386T1 (de) 2005-06-15
WO2002012210A9 (fr) 2002-04-18
CA2418895A1 (fr) 2002-02-14
DE60111393T2 (de) 2006-03-23
DK1309575T3 (da) 2005-09-12
ES2245373T3 (es) 2006-01-01
RU2280033C2 (ru) 2006-07-20
US20040039038A1 (en) 2004-02-26
PL360292A1 (en) 2004-09-06
EP1309575B1 (de) 2005-06-08
CN1468226A (zh) 2004-01-14
FR2812876B1 (fr) 2002-09-27
WO2002012210A1 (fr) 2002-02-14
JP2004505958A (ja) 2004-02-26
FR2812876A1 (fr) 2002-02-15
PT1309575E (pt) 2005-10-31

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