FR2869903B1 - Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques - Google Patents

Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques

Info

Publication number
FR2869903B1
FR2869903B1 FR0404913A FR0404913A FR2869903B1 FR 2869903 B1 FR2869903 B1 FR 2869903B1 FR 0404913 A FR0404913 A FR 0404913A FR 0404913 A FR0404913 A FR 0404913A FR 2869903 B1 FR2869903 B1 FR 2869903B1
Authority
FR
France
Prior art keywords
cosmetic
novel
preparation
pharmaceutical compositions
receptor activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0404913A
Other languages
English (en)
Other versions
FR2869903A1 (fr
Inventor
Jerome Aubert
Laurence Clary
Pascale Mauvais
Michel Rivier
Etienne Thoreau
Jean Guy Boiteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0404913A priority Critical patent/FR2869903B1/fr
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Priority to CNA2005800145211A priority patent/CN1950335A/zh
Priority to PL05743226T priority patent/PL1742608T3/pl
Priority to AT05743226T priority patent/ATE458468T1/de
Priority to ES05743226T priority patent/ES2340178T3/es
Priority to RU2006143054/04A priority patent/RU2006143054A/ru
Priority to PT05743226T priority patent/PT1742608E/pt
Priority to JP2007512127A priority patent/JP2007536331A/ja
Priority to KR1020067023286A priority patent/KR20070015566A/ko
Priority to PCT/EP2005/005797 priority patent/WO2005108352A1/fr
Priority to DE602005019555T priority patent/DE602005019555D1/de
Priority to CA002563955A priority patent/CA2563955A1/fr
Priority to EP05743226A priority patent/EP1742608B1/fr
Priority to BRPI0510223-5A priority patent/BRPI0510223A/pt
Priority to MXPA06012679A priority patent/MXPA06012679A/es
Priority to AU2005240345A priority patent/AU2005240345A1/en
Priority to DK05743226.2T priority patent/DK1742608T3/da
Priority to SI200530933T priority patent/SI1742608T1/sl
Priority to ARP050101786A priority patent/AR048884A1/es
Publication of FR2869903A1 publication Critical patent/FR2869903A1/fr
Publication of FR2869903B1 publication Critical patent/FR2869903B1/fr
Application granted granted Critical
Priority to US11/592,276 priority patent/US7626054B2/en
Priority to ZA200609806A priority patent/ZA200609806B/en
Priority to US12/588,267 priority patent/US7973063B2/en
Priority to CY20101100349T priority patent/CY1110021T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
FR0404913A 2004-05-06 2004-05-06 Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques Expired - Fee Related FR2869903B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR0404913A FR2869903B1 (fr) 2004-05-06 2004-05-06 Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques
AT05743226T ATE458468T1 (de) 2004-05-06 2005-04-29 Biaromatische verbindungen, die rezeptoren des typs ppar(gamma) aktivieren, verfahren zu deren herstellung und deren verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
BRPI0510223-5A BRPI0510223A (pt) 2004-05-06 2005-04-29 compostos, composição cosmética, uso cosmético, uso de um composto, composição farmacêutica e processos para a sìntese de compostos
ES05743226T ES2340178T3 (es) 2004-05-06 2005-04-29 Compuestos biaromaticos que son activadores de los receptores astivados tipo ppar (gamma), su proceso de preparacion y su utilizacion en composiciones cosmeticas o farmaceuticas.
RU2006143054/04A RU2006143054A (ru) 2004-05-06 2005-04-29 Новые биароматические соединения, которые активируют рецепторы ppary-типа, способы их получения и их применение в косметике или в фармацевтических композициях
PT05743226T PT1742608E (pt) 2004-05-06 2005-04-29 Novos compostos biaromáticos que activam receptores do tipo pparγ, o processo para sua preparação e sua utilização em composições cosméticas ou farmacêuticas
JP2007512127A JP2007536331A (ja) 2004-05-06 2005-04-29 ＰＰＡＲγタイプレセプターを活性化する新規二芳香族化合物、それらの調製方法、及び化粧品組成物若しくは製薬組成物におけるそれらの使用
KR1020067023286A KR20070015566A (ko) 2004-05-06 2005-04-29 ＰＰＡＲγ-형 수용체를 활성화하는 신규한 이방향족화합물, 그의 제조 방법 및 미용 또는 약학 조성물에서그의 용도
PCT/EP2005/005797 WO2005108352A1 (fr) 2004-05-06 2005-04-29 Nouveaux composes biaromatiques activant des recepteurs de type ppar$g(g), leur processus de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
DE602005019555T DE602005019555D1 (de) 2004-05-06 2005-04-29 Biaromatische verbindungen, die rezeptoren des typs ppar(gamma) aktivieren, verfahren zu deren herstellung und deren verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
CA002563955A CA2563955A1 (fr) 2004-05-06 2005-04-29 Nouveaux composes biaromatiques activant des recepteurs de type-ppar.gamma., leur processus de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
PL05743226T PL1742608T3 (pl) 2004-05-06 2005-04-29 Biaromatyczne związki, które aktywują receptory typu PPAR(gamma), sposób ich wytwarzania i ich zastosowanie w kompozycjach kosmetycznych lub farmaceutycznych
CNA2005800145211A CN1950335A (zh) 2004-05-06 2005-04-29 活化PPAR－γ型受体的新型联芳族化合物、它们的制备方法以及它们在化妆用或药用组合物中的用途
MXPA06012679A MXPA06012679A (es) 2004-05-06 2005-04-29 Nuevos compuestos biaromaticos que activan receptores tipo ppar (gama), procedimiento de preparacion y uso en composiciones cosmeticas o farmaceuticas.
EP05743226A EP1742608B1 (fr) 2004-05-06 2005-04-29 Composes biaromatiques activant des recepteurs de type ppar(gamma), leur processus de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
DK05743226.2T DK1742608T3 (da) 2004-05-06 2005-04-29 Biaromatiske forbindelser, som aktiverer receptorer af typen PPAR(gamma), fremgangsmåde til fremstilling af disse og deres anvendelse i kosmetik eller farmaceutiske sammensætninger
SI200530933T SI1742608T1 (sl) 2004-05-06 2005-04-29 Bi-aromatiŽŤne spojine, ki aktivirajo receptorje tipa PPAR(GAMA), postopek njihovih izdelav in njihova uporaba v kozmetiŽŤnih ali farmacevtskih zmeseh
AU2005240345A AU2005240345A1 (en) 2004-05-06 2005-04-29 Novel biaromatic compounds which activate PPARgamma-type receptors, their process of preparation and their use in cosmetic or pharmaceutical compositions
ARP050101786A AR048884A1 (es) 2004-05-06 2005-05-04 Compuestos biaromaticos activadores de los receptores de tipo ppar gamma
US11/592,276 US7626054B2 (en) 2004-05-06 2006-11-03 Biaromatic compounds which activate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprised thereof
ZA200609806A ZA200609806B (en) 2004-05-06 2006-11-23 Novel biaromatic compounds which activate PPARy-type receptors, their process of preparation and their use in cosmetic or pharmaceutical compositions
US12/588,267 US7973063B2 (en) 2004-05-06 2009-10-09 Methods for activating PPAR gamma-type receptors
CY20101100349T CY1110021T1 (el) 2004-05-06 2010-04-16 ΔΙΑΡΩΜΑΤΙΚΕΣ ΕΝΩΣΕΙΣ ΟΙ ΟΠΟΙΕΣ ΕΝΕΡΓΟΠΟΙΟΥΝ ΥΠΟΔΟΧΕΙΣ ΤΟΥ ΤΥΠΟΥ PPARγ, ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΑΥΤΩΝ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΣΤΗΝ ΚΟΣΜΗΤΙΚΗ Ή ΣΕ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0404913A FR2869903B1 (fr) 2004-05-06 2004-05-06 Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques

Publications (2)

Publication Number Publication Date
FR2869903A1 FR2869903A1 (fr) 2005-11-11
FR2869903B1 true FR2869903B1 (fr) 2006-06-23

Family

ID=34945757

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0404913A Expired - Fee Related FR2869903B1 (fr) 2004-05-06 2004-05-06 Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques

Country Status (18)

Country Link
EP (1) EP1742608B1 (fr)
JP (1) JP2007536331A (fr)
KR (1) KR20070015566A (fr)
CN (1) CN1950335A (fr)
AR (1) AR048884A1 (fr)
AT (1) ATE458468T1 (fr)
AU (1) AU2005240345A1 (fr)
BR (1) BRPI0510223A (fr)
CA (1) CA2563955A1 (fr)
DK (1) DK1742608T3 (fr)
ES (1) ES2340178T3 (fr)
FR (1) FR2869903B1 (fr)
PL (1) PL1742608T3 (fr)
PT (1) PT1742608E (fr)
RU (1) RU2006143054A (fr)
SI (1) SI1742608T1 (fr)
WO (1) WO2005108352A1 (fr)
ZA (1) ZA200609806B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
EP2991967A1 (fr) * 2013-03-20 2016-03-09 F. Hoffmann-La Roche AG Dérivés d'urée et leurs utilisations en tant qu'inhibiteurs de la protéine de liaison à un acide gras (fabp)
BR112015024113A2 (pt) 2013-03-20 2017-07-18 Hoffmann La Roche derivados de uréia e seu uso como inibidores da proteína de ligação de ácido graxo (fabp)
CN104844476B (zh) * 2015-04-03 2016-08-24 李凌 一种医药中间体联苯类化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812876B1 (fr) 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
CA2506523C (fr) * 2002-11-25 2012-08-28 Galderma Research & Development, S.N.C. Nouveaux composes biaromatiques activant les recepteurs ppar-gamma et utilisation desdits composes dans les compositions cosmetiques et pharmaceutiques

Also Published As

Publication number Publication date
RU2006143054A (ru) 2008-06-20
DK1742608T3 (da) 2010-05-17
WO2005108352A1 (fr) 2005-11-17
JP2007536331A (ja) 2007-12-13
CA2563955A1 (fr) 2005-11-17
AR048884A1 (es) 2006-06-07
EP1742608A1 (fr) 2007-01-17
PT1742608E (pt) 2010-04-27
BRPI0510223A (pt) 2007-10-23
CN1950335A (zh) 2007-04-18
ATE458468T1 (de) 2010-03-15
ZA200609806B (en) 2007-12-27
AU2005240345A1 (en) 2005-11-17
PL1742608T3 (pl) 2010-07-30
SI1742608T1 (sl) 2010-04-30
ES2340178T3 (es) 2010-05-31
KR20070015566A (ko) 2007-02-05
EP1742608B1 (fr) 2010-02-24
FR2869903A1 (fr) 2005-11-11

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