DE60103921D1 - Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte - Google Patents

Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte

Info

Publication number
DE60103921D1
DE60103921D1 DE60103921T DE60103921T DE60103921D1 DE 60103921 D1 DE60103921 D1 DE 60103921D1 DE 60103921 T DE60103921 T DE 60103921T DE 60103921 T DE60103921 T DE 60103921T DE 60103921 D1 DE60103921 D1 DE 60103921D1
Authority
DE
Germany
Prior art keywords
thiopyran
dioxides
dihydro
sulfonamide
alkylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103921T
Other languages
English (en)
Other versions
DE60103921T2 (de
Inventor
Losada Pablo Garcia
Guisasola L O Silva
Bonde-Larsen A Lorente
Juarez Jorge Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ragactives SL
Original Assignee
Ragactives SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ragactives SL filed Critical Ragactives SL
Application granted granted Critical
Publication of DE60103921D1 publication Critical patent/DE60103921D1/de
Publication of DE60103921T2 publication Critical patent/DE60103921T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60103921T 2000-09-04 2001-09-04 Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte Expired - Lifetime DE60103921T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200002171 2000-09-04
ES200002171A ES2177415B1 (es) 2000-09-04 2000-09-04 Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
PCT/ES2001/000335 WO2002020529A1 (es) 2000-09-04 2001-09-04 PROCEDIMIENTO PARA LA OBTENCIÓN DE 4-(N-ALQUILAMINO)-5,6-DIHIDRO-4H-TIENO-(2,3-b)-TIOPIRAN-2-SULFONAMIDA-7,7-DIÓXIDOS, E INTERMEDIOS

Publications (2)

Publication Number Publication Date
DE60103921D1 true DE60103921D1 (de) 2004-07-22
DE60103921T2 DE60103921T2 (de) 2005-06-30

Family

ID=8494840

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103921T Expired - Lifetime DE60103921T2 (de) 2000-09-04 2001-09-04 Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte

Country Status (9)

Country Link
US (1) US7030250B2 (de)
EP (1) EP1329453B1 (de)
JP (1) JP5137284B2 (de)
AT (1) ATE269338T1 (de)
AU (1) AU2001285958A1 (de)
CA (1) CA2436185C (de)
DE (1) DE60103921T2 (de)
ES (2) ES2177415B1 (de)
WO (1) WO2002020529A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE380190T1 (de) * 2004-07-09 2007-12-15 Fdc Ltd Verbessertes verfahren zur herstellung von 5,6 - dihydro -4h-4(s)-ethylamin-6(s)-methylthieno(2,3- b) thiopyran-2-sulfonamid- 7,7 -dioxid und seinen salzen
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) * 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
EP1753769A2 (de) 2005-01-06 2007-02-21 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur herstellung von dorzolamidhydrochlorid
WO2006078731A2 (en) * 2005-01-18 2006-07-27 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
CN1939923B (zh) * 2005-09-30 2010-05-05 北京德众万全医药科技有限公司 一种多佐胺中间体的制备方法
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
EP2309858A4 (de) 2008-07-31 2011-09-14 Dekel Pharmaceuticals Ltd Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen
JP2018536017A (ja) 2015-09-22 2018-12-06 グレイバグ ビジョン インコーポレイテッド 眼障害の治療のための化合物及び組成物
EP3600324A4 (de) 2017-03-23 2020-12-09 Graybug Vision, Inc. Arzneimittel und zusammensetzungen zur behandlung von augenkrankheiten
CN111201040A (zh) 2017-05-10 2020-05-26 灰色视觉公司 用于医学疗法的缓释微粒及其悬浮液
TW202035364A (zh) * 2018-09-27 2020-10-01 美商灰色視覺公司 用於眼部遞送之化合物及組合物
JP2022521452A (ja) * 2019-01-09 2022-04-08 イェダ リサーチ アンド ディベロップメント カンパニー リミテッド Ｐｉｎ１活性のモジュレータおよびその使用
CN113336770B (zh) * 2021-06-24 2022-05-20 中南林业科技大学 一种盐酸多佐胺的手性合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820848A (en) 1984-12-12 1989-04-11 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US4797413A (en) 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4824968A (en) 1984-12-12 1989-04-25 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US4677115A (en) 1984-12-12 1987-06-30 Merck & Co., Inc. Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US5120757A (en) * 1989-07-31 1992-06-09 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US5011942A (en) * 1990-02-05 1991-04-30 Merck & Co., Inc. Process for racemizing an enantiomer of 5,6-dihydro-4-alkylamino-4H-thieno(or furo) [2,3-B]-thiopyran-2-sulfonamide-7,7-dioxide
IE911192A1 (en) * 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
JP3333206B2 (ja) 1992-08-28 2002-10-15 アベシア・リミテッド 不斉還元方法
JP3279671B2 (ja) 1992-09-28 2002-04-30 鐘淵化学工業株式会社 チエノチオピラン誘導体の製造方法
TW265343B (de) * 1993-03-22 1995-12-11 Merck & Co Inc
US5391772A (en) 1993-07-08 1995-02-21 Merck & Co., Inc. Converting an alcohol to an azide with SN 2 inversion using a phosphoryl azide
US5441722A (en) * 1994-02-18 1995-08-15 Merck & Co., Inc. Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3 H3 ]-4[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds
US5474919A (en) 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae
US5760249A (en) 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds

Also Published As

Publication number Publication date
EP1329453A1 (de) 2003-07-23
AU2001285958A1 (en) 2002-03-22
WO2002020529A1 (es) 2002-03-14
ES2177415B1 (es) 2004-10-16
DE60103921T2 (de) 2005-06-30
ES2223907T3 (es) 2005-03-01
WO2002020529A8 (es) 2002-07-25
US20030220509A1 (en) 2003-11-27
US7030250B2 (en) 2006-04-18
ATE269338T1 (de) 2004-07-15
CA2436185C (en) 2009-06-02
CA2436185A1 (en) 2002-03-14
ES2177415A1 (es) 2002-12-01
EP1329453B1 (de) 2004-06-16
JP5137284B2 (ja) 2013-02-06
JP2004508375A (ja) 2004-03-18

Similar Documents

Publication Publication Date Title
DE60103921D1 (de) Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte
DE69527429D1 (de) Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon
DE60111612D1 (de) Ss'-bis-(alpha, alpha'-disubstituierte-alpha''-essigsäure)-trithio-carbonate und derivate davon als initiatoren, kettentransfer-verbindung, kettenabbruch-verbindung für kontrollierte radikalische polymerisationen sowie verfahren zu deren herstellung
DE69722027D1 (de) Kristalle von benzimidazolderivate und verfahren zu ihrer herstellung
NZ513639A (en) Cyclic protein tyrosine kinase inhibitors
DE69405864D1 (de) Verfahren zur Herstellung von quaternären Diestern
ATE373638T1 (de) Fettsäureverbindungen und deren herstellung und verwendungen
ATE349412T1 (de) Epothilon-synthesebausteine i: unsymmetrisch substituierte acyloine und acyloinderivate, verfahren zu deren herstellung sowie deren verwendung zur herstellung von epothilonen und epothilonderivaten
DE69705480T2 (de) Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
HUP0303034A2 (hu) Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukra
DE3866665D1 (de) Verwendung von organosilicium-verbindungen zum verdicken von oelen.
ATE102482T1 (de) Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit.
ATE201025T1 (de) Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren
ATE211137T1 (de) Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
ATE348811T1 (de) Verfahren zur herstellung von 2- aminomethylpyridin-derivaten
DE60224884D1 (de) Verfahren zur herstellung von 3, 3', 6, 6'-tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'-tetraalkylen-5, 5'-dihalo-2, 2' biphenolen
DE69119509D1 (de) Benzhydryloxyethylpiperidyl-Derivate aliphatischer Carbonsäuren und ihre Anwendung zur Behandlung von Allergien und Asthma
ATE149494T1 (de) Benzopyranderivate und verfahren zu deren herstellung
ATE365162T1 (de) Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
DE69418961T2 (de) Benzothiazol-derivate, verfahren zur herstellung sowie anwendungen
ATE275558T1 (de) 4-arylpiperidinderivate zur behandlung von pruritus
DE59507361D1 (de) Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung als Glukose-6-Phosphatase Inhibitoren
DE60001298D1 (de) Verfahren zur Herstellung von Omeprazol
ATE195115T1 (de) Verfahren zur herstellung von 5,6-dihydroxy-2- amino-1,2,3,4-tetrahydronaphthalin-derivaten
PT96671A (pt) Processo para a preparacao de derivados de tetralina e de cromano, uteis no tratamento da asma,da artrite e de doencas relacionadas

Legal Events

Date Code Title Description
8364 No opposition during term of opposition