DE60103921D1 - Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte - Google Patents

Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte

Info

Publication number
DE60103921D1
DE60103921D1 DE60103921T DE60103921T DE60103921D1 DE 60103921 D1 DE60103921 D1 DE 60103921D1 DE 60103921 T DE60103921 T DE 60103921T DE 60103921 T DE60103921 T DE 60103921T DE 60103921 D1 DE60103921 D1 DE 60103921D1
Authority
DE
Germany
Prior art keywords
thiopyran
dioxides
dihydro
sulfonamide
alkylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103921T
Other languages
English (en)
Other versions
DE60103921T2 (de
Inventor
Losada Pablo Garcia
Guisasola L O Silva
Bonde-Larsen A Lorente
Juarez Jorge Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ragactives SL
Original Assignee
Ragactives SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ragactives SL filed Critical Ragactives SL
Publication of DE60103921D1 publication Critical patent/DE60103921D1/de
Application granted granted Critical
Publication of DE60103921T2 publication Critical patent/DE60103921T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60103921T 2000-09-04 2001-09-04 Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte Expired - Lifetime DE60103921T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200002171A ES2177415B1 (es) 2000-09-04 2000-09-04 Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES200002171 2000-09-04
PCT/ES2001/000335 WO2002020529A1 (es) 2000-09-04 2001-09-04 PROCEDIMIENTO PARA LA OBTENCIÓN DE 4-(N-ALQUILAMINO)-5,6-DIHIDRO-4H-TIENO-(2,3-b)-TIOPIRAN-2-SULFONAMIDA-7,7-DIÓXIDOS, E INTERMEDIOS

Publications (2)

Publication Number Publication Date
DE60103921D1 true DE60103921D1 (de) 2004-07-22
DE60103921T2 DE60103921T2 (de) 2005-06-30

Family

ID=8494840

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103921T Expired - Lifetime DE60103921T2 (de) 2000-09-04 2001-09-04 Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-thiopyran-2-sulfonamid-7,7-dioxiden und zwischenprodukte

Country Status (9)

Country Link
US (1) US7030250B2 (de)
EP (1) EP1329453B1 (de)
JP (1) JP5137284B2 (de)
AT (1) ATE269338T1 (de)
AU (1) AU2001285958A1 (de)
CA (1) CA2436185C (de)
DE (1) DE60103921T2 (de)
ES (2) ES2177415B1 (de)
WO (1) WO2002020529A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1765828B1 (de) * 2004-07-09 2007-12-05 FDC Limited VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON 5,6 -DIHYDRO -4H-4(S)-ETHYLAMIN-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMID- 7,7 -DIOXID UND SEINEN SALZEN
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) * 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
US20060155132A1 (en) * 2005-01-06 2006-07-13 Kovacs Laszlo Z Method of making dorzolamide hydrochloride
US20060173068A1 (en) * 2005-01-18 2006-08-03 Judith Aronhime Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
CN1939923B (zh) * 2005-09-30 2010-05-05 北京德众万全医药科技有限公司 一种多佐胺中间体的制备方法
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
WO2010013240A1 (en) 2008-07-31 2010-02-04 Dekel Pharmaceuticals Ltd. Compositions and methods for treating inflammatory disorders
KR20180058758A (ko) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. 안구 장애의 치료를 위한 화합물 및 조성물
CN110662543A (zh) 2017-03-23 2020-01-07 灰色视觉公司 用于治疗眼部疾病的药物和组合物
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2020069353A1 (en) * 2018-09-27 2020-04-02 Graybug Vision, Inc. Compounds and compositions for ocular delivery
EP3908268A1 (de) * 2019-01-09 2021-11-17 Yeda Research and Development Co. Ltd Modulatoren von pin1-aktivität und verwendungen davon
CN113336770B (zh) * 2021-06-24 2022-05-20 中南林业科技大学 一种盐酸多佐胺的手性合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4820848A (en) * 1984-12-12 1989-04-11 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US4677115A (en) * 1984-12-12 1987-06-30 Merck & Co., Inc. Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4824968A (en) * 1984-12-12 1989-04-25 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US5120757A (en) * 1989-07-31 1992-06-09 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US5011942A (en) * 1990-02-05 1991-04-30 Merck & Co., Inc. Process for racemizing an enantiomer of 5,6-dihydro-4-alkylamino-4H-thieno(or furo) [2,3-B]-thiopyran-2-sulfonamide-7,7-dioxide
IE911192A1 (en) * 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
KR100319837B1 (ko) 1992-08-28 2002-04-22 커스티 마가렛 핀더 4h-티에노(2,3-6)티오피란유도체를제조하기위한효소적비대칭환원방법
JP3279671B2 (ja) 1992-09-28 2002-04-30 鐘淵化学工業株式会社 チエノチオピラン誘導体の製造方法
TW265343B (de) * 1993-03-22 1995-12-11 Merck & Co Inc
US5391772A (en) * 1993-07-08 1995-02-21 Merck & Co., Inc. Converting an alcohol to an azide with SN 2 inversion using a phosphoryl azide
US5441722A (en) * 1994-02-18 1995-08-15 Merck & Co., Inc. Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3 H3 ]-4[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds
US5474919A (en) * 1994-09-13 1995-12-12 Merck & Co., Inc. Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds

Also Published As

Publication number Publication date
US20030220509A1 (en) 2003-11-27
AU2001285958A1 (en) 2002-03-22
CA2436185C (en) 2009-06-02
WO2002020529A1 (es) 2002-03-14
US7030250B2 (en) 2006-04-18
WO2002020529A8 (es) 2002-07-25
ES2223907T3 (es) 2005-03-01
JP2004508375A (ja) 2004-03-18
ATE269338T1 (de) 2004-07-15
EP1329453B1 (de) 2004-06-16
EP1329453A1 (de) 2003-07-23
DE60103921T2 (de) 2005-06-30
JP5137284B2 (ja) 2013-02-06
CA2436185A1 (en) 2002-03-14
ES2177415B1 (es) 2004-10-16
ES2177415A1 (es) 2002-12-01

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