ATE269338T1 - Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-t iopyran-2-sulfonamid- 7,7-dioxiden und zwischenprodukte - Google Patents
Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-t iopyran-2-sulfonamid- 7,7-dioxiden und zwischenprodukteInfo
- Publication number
- ATE269338T1 ATE269338T1 AT01965290T AT01965290T ATE269338T1 AT E269338 T1 ATE269338 T1 AT E269338T1 AT 01965290 T AT01965290 T AT 01965290T AT 01965290 T AT01965290 T AT 01965290T AT E269338 T1 ATE269338 T1 AT E269338T1
- Authority
- AT
- Austria
- Prior art keywords
- dioxides
- dihydro
- sulfonamide
- iopyran
- alkylamin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002171A ES2177415B1 (es) | 2000-09-04 | 2000-09-04 | Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios. |
PCT/ES2001/000335 WO2002020529A1 (es) | 2000-09-04 | 2001-09-04 | PROCEDIMIENTO PARA LA OBTENCIÓN DE 4-(N-ALQUILAMINO)-5,6-DIHIDRO-4H-TIENO-(2,3-b)-TIOPIRAN-2-SULFONAMIDA-7,7-DIÓXIDOS, E INTERMEDIOS |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE269338T1 true ATE269338T1 (de) | 2004-07-15 |
Family
ID=8494840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01965290T ATE269338T1 (de) | 2000-09-04 | 2001-09-04 | Verfahren zur herstellung von 4-(n-alkylamin)-5,6-dihydro-4h-thieno-(2,3-b)-t iopyran-2-sulfonamid- 7,7-dioxiden und zwischenprodukte |
Country Status (9)
Country | Link |
---|---|
US (1) | US7030250B2 (de) |
EP (1) | EP1329453B1 (de) |
JP (1) | JP5137284B2 (de) |
AT (1) | ATE269338T1 (de) |
AU (1) | AU2001285958A1 (de) |
CA (1) | CA2436185C (de) |
DE (1) | DE60103921T2 (de) |
ES (2) | ES2177415B1 (de) |
WO (1) | WO2002020529A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006038222A1 (en) * | 2004-07-09 | 2006-04-13 | Fdc Ltd | AN IMPROVED PROCESS FOR THE PREPARATION OF 5,6 -DIHYDRO -4H-4(S)-ETHYLAMINO-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMIDE- 7,7 -DIOXIDE AND ITS SALT |
ES2253112B1 (es) * | 2004-11-05 | 2007-03-16 | Ragactives, S.L. | Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano. |
US7109353B2 (en) * | 2004-12-28 | 2006-09-19 | Council Of Scientific And Industrial Research | Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl |
WO2006074230A2 (en) * | 2005-01-06 | 2006-07-13 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method of making dorzolamide hydrochloride |
JP2008526780A (ja) * | 2005-01-18 | 2008-07-24 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ドルゾルアミド塩酸塩の非晶質および結晶質の形態およびそれらを製造する方法 |
CN1939923B (zh) * | 2005-09-30 | 2010-05-05 | 北京德众万全医药科技有限公司 | 一种多佐胺中间体的制备方法 |
LT5504B (lt) | 2006-08-02 | 2008-06-25 | Biotechnologijos Institutas | Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti |
US9623000B2 (en) | 2008-07-31 | 2017-04-18 | Dekel Pharmaceuticals Ltd | Compositions and methods for treating inflammatory disorders |
MX2018003462A (es) | 2015-09-22 | 2018-09-06 | Graybug Vision Inc | Compuestos y composiciones para el tratamiento de trastornos oculares. |
JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
EP3621654A4 (de) | 2017-05-10 | 2021-02-17 | Graybug Vision, Inc. | Mikropartikel mit verlängerter freisetzung und suspensionen davon zur medizinischen therapie |
WO2020069353A1 (en) * | 2018-09-27 | 2020-04-02 | Graybug Vision, Inc. | Compounds and compositions for ocular delivery |
CN113939285A (zh) * | 2019-01-09 | 2022-01-14 | 耶达研究及发展有限公司 | Pin1活性的调节剂及其用途 |
CN113336770B (zh) * | 2021-06-24 | 2022-05-20 | 中南林业科技大学 | 一种盐酸多佐胺的手性合成方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863922A (en) * | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
US4820848A (en) * | 1984-12-12 | 1989-04-11 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents |
US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US4677115A (en) * | 1984-12-12 | 1987-06-30 | Merck & Co., Inc. | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof |
US4824968A (en) * | 1984-12-12 | 1989-04-25 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents |
US5120757A (en) * | 1989-07-31 | 1992-06-09 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents |
US5011942A (en) * | 1990-02-05 | 1991-04-30 | Merck & Co., Inc. | Process for racemizing an enantiomer of 5,6-dihydro-4-alkylamino-4H-thieno(or furo) [2,3-B]-thiopyran-2-sulfonamide-7,7-dioxide |
IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
US5091409A (en) * | 1990-05-17 | 1992-02-25 | Merck & Co., Inc. | 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides |
ES2093980T3 (es) | 1992-08-28 | 1997-01-01 | Zeneca Ltd | Proceso de reduccion asimetrica, enzimatica, para producir derivados de 4h-tieno(2,3-6)tiopirano. |
JP3279671B2 (ja) | 1992-09-28 | 2002-04-30 | 鐘淵化学工業株式会社 | チエノチオピラン誘導体の製造方法 |
TW265343B (de) * | 1993-03-22 | 1995-12-11 | Merck & Co Inc | |
US5391772A (en) * | 1993-07-08 | 1995-02-21 | Merck & Co., Inc. | Converting an alcohol to an azide with SN 2 inversion using a phosphoryl azide |
US5441722A (en) * | 1994-02-18 | 1995-08-15 | Merck & Co., Inc. | Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3 H3 ]-4[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds |
US5474919A (en) * | 1994-09-13 | 1995-12-12 | Merck & Co., Inc. | Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae |
US5760249A (en) * | 1995-08-29 | 1998-06-02 | Merck & Co., Inc. | Synthesis of hydroxysulfone and related compounds |
-
2000
- 2000-09-04 ES ES200002171A patent/ES2177415B1/es not_active Expired - Fee Related
-
2001
- 2001-09-04 DE DE60103921T patent/DE60103921T2/de not_active Expired - Lifetime
- 2001-09-04 WO PCT/ES2001/000335 patent/WO2002020529A1/es active IP Right Grant
- 2001-09-04 AT AT01965290T patent/ATE269338T1/de not_active IP Right Cessation
- 2001-09-04 ES ES01965290T patent/ES2223907T3/es not_active Expired - Lifetime
- 2001-09-04 EP EP01965290A patent/EP1329453B1/de not_active Expired - Lifetime
- 2001-09-04 AU AU2001285958A patent/AU2001285958A1/en not_active Abandoned
- 2001-09-04 CA CA002436185A patent/CA2436185C/en not_active Expired - Fee Related
- 2001-09-04 JP JP2002525150A patent/JP5137284B2/ja not_active Expired - Fee Related
-
2003
- 2003-03-03 US US10/379,096 patent/US7030250B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2001285958A1 (en) | 2002-03-22 |
EP1329453B1 (de) | 2004-06-16 |
WO2002020529A1 (es) | 2002-03-14 |
CA2436185C (en) | 2009-06-02 |
US20030220509A1 (en) | 2003-11-27 |
ES2177415B1 (es) | 2004-10-16 |
WO2002020529A8 (es) | 2002-07-25 |
DE60103921T2 (de) | 2005-06-30 |
US7030250B2 (en) | 2006-04-18 |
JP2004508375A (ja) | 2004-03-18 |
JP5137284B2 (ja) | 2013-02-06 |
EP1329453A1 (de) | 2003-07-23 |
ES2223907T3 (es) | 2005-03-01 |
CA2436185A1 (en) | 2002-03-14 |
DE60103921D1 (de) | 2004-07-22 |
ES2177415A1 (es) | 2002-12-01 |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |