DE60035163D1 - Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts - Google Patents
Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehaltsInfo
- Publication number
- DE60035163D1 DE60035163D1 DE60035163T DE60035163T DE60035163D1 DE 60035163 D1 DE60035163 D1 DE 60035163D1 DE 60035163 T DE60035163 T DE 60035163T DE 60035163 T DE60035163 T DE 60035163T DE 60035163 D1 DE60035163 D1 DE 60035163D1
- Authority
- DE
- Germany
- Prior art keywords
- modulating
- reagents
- cholesterol content
- polypeptides
- abc1 polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 6
- 102100030488 HEAT repeat-containing protein 6 Human genes 0.000 title abstract 2
- 101000990566 Homo sapiens HEAT repeat-containing protein 6 Proteins 0.000 title abstract 2
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12470299P | 1999-03-15 | 1999-03-15 | |
US124702P | 1999-03-15 | ||
US13804899P | 1999-06-08 | 1999-06-08 | |
US138048P | 1999-06-08 | ||
US13960099P | 1999-06-17 | 1999-06-17 | |
US139600P | 1999-06-17 | ||
US15197799P | 1999-09-01 | 1999-09-01 | |
US151977P | 1999-09-01 | ||
PCT/IB2000/000532 WO2000055318A2 (en) | 1999-03-15 | 2000-03-15 | Abc1 polypeptide and methods and reagents for modulating cholesterol levels |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60035163D1 true DE60035163D1 (de) | 2007-07-26 |
DE60035163T2 DE60035163T2 (de) | 2008-02-21 |
Family
ID=27494556
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60035163T Expired - Lifetime DE60035163T2 (de) | 1999-03-15 | 2000-03-15 | Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts |
DE1100895T Pending DE1100895T1 (de) | 1999-03-15 | 2000-03-15 | Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1100895T Pending DE1100895T1 (de) | 1999-03-15 | 2000-03-15 | Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts |
Country Status (8)
Country | Link |
---|---|
US (6) | US6617122B1 (de) |
EP (1) | EP1100895B1 (de) |
JP (1) | JP4726302B2 (de) |
AT (1) | ATE364696T1 (de) |
AU (1) | AU784108B2 (de) |
CA (1) | CA2367955C (de) |
DE (2) | DE60035163T2 (de) |
WO (1) | WO2000055318A2 (de) |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5997680A (en) | 1996-04-30 | 1999-12-07 | Avery Dennison Corporation | Method of producing printed media |
CA2367955C (en) * | 1999-03-15 | 2009-05-19 | University Of British Columbia | Abc1 polypeptide and methods and reagents for modulating cholesterol levels |
US6835563B1 (en) | 1999-06-18 | 2004-12-28 | Cv Therapeutics | Compositions and methods for increasing cholesterol efflux and raising HDL ATP binding cassette transporter protein ABC1 |
AU1291901A (en) * | 1999-09-01 | 2001-03-26 | University Of British Columbia, The | Compositions and methods for modulating hdl cholesterol and triglyceride levels |
AU1452601A (en) | 1999-11-01 | 2001-05-14 | Wisconsin Alumni Research Foundation | Cholesterol transport gene |
US6555323B2 (en) * | 2000-02-08 | 2003-04-29 | Pfizer Inc. | Assay for ABCA1 |
CA2304906A1 (en) * | 2000-04-07 | 2001-10-07 | 1411198 Ontario Limited | 13-hode, a regulator of vascular biocompatibility and an inhibitor of cell hyperplasia |
WO2001083746A2 (en) * | 2000-05-02 | 2001-11-08 | Aventis Pharma S.A. | Regulatory nucleic acid sequences of the abc1 gene |
FR2815970A1 (fr) * | 2000-10-31 | 2002-05-03 | Aventis Pharma Sa | Sequences polymorphes du gene humain abca1, leurs utilisations, les methodes et kits de detection |
WO2002036770A2 (fr) * | 2000-10-31 | 2002-05-10 | Aventis Pharma S.A. | Sequences polymorphes du gene humain abca1, leurs utilisations, les methodes et kits de detection |
EP1203588A1 (de) * | 2000-11-06 | 2002-05-08 | Bayer Ag | Sterol-unabhängige Regulierung des ABC1 Promotors mit OncostatinM |
US20020127647A1 (en) * | 2000-11-28 | 2002-09-12 | John Shutter | ATP-binding cassette transporter-like molecules and uses thereof |
US20020169137A1 (en) * | 2001-02-09 | 2002-11-14 | Active Pass Pharmaceuticals, Inc. | Regulation of amyloid precursor protein expression by modification of ABC transporter expression or activity |
US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
WO2002084301A2 (en) * | 2001-04-12 | 2002-10-24 | Xenon Genetics, Inc. | Screening assay for agents modulating activity of the abca1 protein |
US20050003356A1 (en) * | 2001-05-25 | 2005-01-06 | Hayden Michael R. | Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels |
EP1399426A2 (de) * | 2001-06-12 | 2004-03-24 | Active Pass Pharmaceuticals, Inc. | VERBINDUNGEN, ZUSAMMENSTELLUNGEN UND METHODE FüR DIE BETA-AMYLOIDE MODULATION |
US20030027301A1 (en) * | 2001-06-14 | 2003-02-06 | Yi Hu | Novel human transporter proteins and polynucleotides encoding the same |
WO2003004692A2 (en) * | 2001-07-03 | 2003-01-16 | Xenon Genetics, Inc. | Screening processes for agents modulating cholesterol levels |
US20030113728A1 (en) * | 2001-12-14 | 2003-06-19 | Jukka Salonen | Method for assessing the risk of cardiovascular disease |
KR100623128B1 (ko) * | 2002-01-02 | 2006-09-14 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
EP1511483A4 (de) * | 2002-03-27 | 2009-03-18 | Smithkline Beecham Corp | Verfahren zur behandlung mit lxr-modulatoren |
US20050289657A1 (en) * | 2002-04-18 | 2005-12-29 | Thomas Hesterkamp | Diagnostic and therapeutic use of an atp-binding cassette gene and protein for neurodegenerative diseases |
US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US20040033480A1 (en) * | 2002-08-15 | 2004-02-19 | Wong Norman C.W. | Use of resveratrol to regulate expression of apolipoprotein A1 |
US20050080021A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders |
US20050080024A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
FR2847266A1 (fr) * | 2002-11-15 | 2004-05-21 | Genfit S A | Methodes de criblage de composes modulant le flux de cholesterol et utilisations |
US20050136421A1 (en) * | 2003-12-23 | 2005-06-23 | Hayden Michael R. | Methods and reagents for modulating cholesterol levels |
EP1566202A1 (de) * | 2004-02-23 | 2005-08-24 | Sahltech I Göteborg AB | Verwendung von resistin-antagonisten zur behandlung von Rheumatoider arthritis |
US7608413B1 (en) * | 2005-03-25 | 2009-10-27 | Celera Corporation | Kidney disease targets and uses thereof |
CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
CA2960105A1 (en) | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
CA2617969A1 (en) * | 2005-08-10 | 2007-02-15 | Takeda Pharmaceutical Company Limited | Therapeutic agent for diabetes |
CN101437933B (zh) | 2005-12-28 | 2013-11-06 | 斯克里普斯研究所 | 作为药物靶标的天然反义和非编码的rna转录物 |
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- 2000-03-15 AT AT00917240T patent/ATE364696T1/de not_active IP Right Cessation
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EP1100895B1 (de) | 2007-06-13 |
DE60035163T2 (de) | 2008-02-21 |
US7785886B2 (en) | 2010-08-31 |
US20110065147A1 (en) | 2011-03-17 |
JP2003513611A (ja) | 2003-04-15 |
EP1100895A2 (de) | 2001-05-23 |
US8715968B2 (en) | 2014-05-06 |
AU3832700A (en) | 2000-10-04 |
US20040157250A1 (en) | 2004-08-12 |
ATE364696T1 (de) | 2007-07-15 |
WO2000055318A8 (en) | 2001-07-12 |
CA2367955A1 (en) | 2000-09-21 |
AU784108B2 (en) | 2006-02-02 |
US20040058869A1 (en) | 2004-03-25 |
US20040185508A1 (en) | 2004-09-23 |
JP4726302B2 (ja) | 2011-07-20 |
WO2000055318A2 (en) | 2000-09-21 |
CA2367955C (en) | 2009-05-19 |
DE1100895T1 (de) | 2001-09-06 |
US6617122B1 (en) | 2003-09-09 |
US20040005666A1 (en) | 2004-01-08 |
WO2000055318A3 (en) | 2001-03-22 |
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