DE60034959T2 - Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren - Google Patents
Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren Download PDFInfo
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- DE60034959T2 DE60034959T2 DE60034959T DE60034959T DE60034959T2 DE 60034959 T2 DE60034959 T2 DE 60034959T2 DE 60034959 T DE60034959 T DE 60034959T DE 60034959 T DE60034959 T DE 60034959T DE 60034959 T2 DE60034959 T2 DE 60034959T2
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US16089999P | 1999-10-22 | 1999-10-22 | |
| US160899P | 1999-10-22 | ||
| US22152500P | 2000-07-28 | 2000-07-28 | |
| US221525P | 2000-07-28 | ||
| PCT/US2000/041423 WO2001028577A2 (en) | 1999-10-22 | 2000-10-20 | Inhibition of cell motility and angiogenesis by inhibitors of the grb2 sh2-domain |
Publications (2)
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| DE60034959D1 DE60034959D1 (de) | 2007-07-05 |
| DE60034959T2 true DE60034959T2 (de) | 2008-01-17 |
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| DE60034959T Expired - Lifetime DE60034959T2 (de) | 1999-10-22 | 2000-10-20 | Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7132392B1 (https=) |
| EP (1) | EP1223959B1 (https=) |
| JP (1) | JP2003512334A (https=) |
| AT (1) | ATE362767T1 (https=) |
| AU (1) | AU780697B2 (https=) |
| CA (1) | CA2387922C (https=) |
| DE (1) | DE60034959T2 (https=) |
| ES (1) | ES2287048T3 (https=) |
| WO (1) | WO2001028577A2 (https=) |
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| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
| WO2004003005A2 (en) * | 2002-06-28 | 2004-01-08 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sh2 domain binding inhibitors |
| US7425537B2 (en) | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
| US20040253294A1 (en) * | 2001-07-18 | 2004-12-16 | Yasuhiko Tabata | Sustained release hgf hydrogel preparations |
| US20080081841A1 (en) * | 2003-03-20 | 2008-04-03 | Badache Ali | Materials and Methods for Modulating Cell Motility |
| EP2350656B1 (en) * | 2008-10-30 | 2015-01-07 | The Translational Genomics Research Institute | Methods and kits to identify invasive glioblastoma |
| CN110981938A (zh) * | 2019-12-10 | 2020-04-10 | 中山大学·深圳 | 靶向grb2 sh2结合域的抗肿瘤多肽及其应用 |
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| US3906031A (en) | 1971-03-15 | 1975-09-16 | Research Corp | Novel 9-fluorenylmethoxycarbonyl compounds |
| US4394519A (en) | 1982-01-19 | 1983-07-19 | Research Corporation | Amino acid blocking agents |
| US4879398A (en) | 1987-12-31 | 1989-11-07 | Monsanto Company | Process for producing 2,6-disubstituted tyrosine |
| US5296608A (en) | 1988-04-25 | 1994-03-22 | Hoffman-La Roche Inc. | Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides |
| US5182263A (en) | 1988-04-25 | 1993-01-26 | Hoffmann-La Roche Inc. | Analogs of tyrosine sulfate or tyrosine phosphate containing peptides |
| US5272268A (en) | 1990-06-28 | 1993-12-21 | Shionogi & Co., Ltd. | Dipeptide derivatives |
| US5679842A (en) | 1990-08-17 | 1997-10-21 | Hoechst Aktiengesellschaft | Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids |
| AU657498B2 (en) | 1990-12-14 | 1995-03-16 | Novartis Ag | Biphenylyl compounds |
| DE4115468A1 (de) | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
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-
2000
- 2000-10-20 JP JP2001531405A patent/JP2003512334A/ja active Pending
- 2000-10-20 AT AT00992431T patent/ATE362767T1/de not_active IP Right Cessation
- 2000-10-20 EP EP00992431A patent/EP1223959B1/en not_active Expired - Lifetime
- 2000-10-20 DE DE60034959T patent/DE60034959T2/de not_active Expired - Lifetime
- 2000-10-20 AU AU29166/01A patent/AU780697B2/en not_active Ceased
- 2000-10-20 ES ES00992431T patent/ES2287048T3/es not_active Expired - Lifetime
- 2000-10-20 WO PCT/US2000/041423 patent/WO2001028577A2/en not_active Ceased
- 2000-10-20 US US10/111,192 patent/US7132392B1/en not_active Expired - Fee Related
- 2000-10-20 CA CA2387922A patent/CA2387922C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2387922C (en) | 2011-12-06 |
| DE60034959D1 (de) | 2007-07-05 |
| CA2387922A1 (en) | 2001-04-26 |
| WO2001028577A2 (en) | 2001-04-26 |
| WO2001028577A3 (en) | 2001-12-13 |
| ES2287048T3 (es) | 2007-12-16 |
| AU780697B2 (en) | 2005-04-14 |
| EP1223959B1 (en) | 2007-05-23 |
| AU2916601A (en) | 2001-04-30 |
| US7132392B1 (en) | 2006-11-07 |
| JP2003512334A (ja) | 2003-04-02 |
| EP1223959A2 (en) | 2002-07-24 |
| ATE362767T1 (de) | 2007-06-15 |
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