DE60034959D1 - Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren - Google Patents

Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren

Info

Publication number
DE60034959D1
DE60034959D1 DE60034959T DE60034959T DE60034959D1 DE 60034959 D1 DE60034959 D1 DE 60034959D1 DE 60034959 T DE60034959 T DE 60034959T DE 60034959 T DE60034959 T DE 60034959T DE 60034959 D1 DE60034959 D1 DE 60034959D1
Authority
DE
Germany
Prior art keywords
present
methods
inhibiting
angiogenesis
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034959T
Other languages
English (en)
Other versions
DE60034959T2 (de
Inventor
Donald P Bottaro
Safiye N Atabey
Jesus V Soriano
Diane E Breckenridge
Zhu-Jun Yao
Yang Gao
Terrence R Burke Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of DE60034959D1 publication Critical patent/DE60034959D1/de
Application granted granted Critical
Publication of DE60034959T2 publication Critical patent/DE60034959T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60034959T 1999-10-22 2000-10-20 Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren Expired - Lifetime DE60034959T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16089999P 1999-10-22 1999-10-22
US160899P 1999-10-22
US22152500P 2000-07-28 2000-07-28
US221525P 2000-07-28
PCT/US2000/041423 WO2001028577A2 (en) 1999-10-22 2000-10-20 Inhibition of cell motility and angiogenesis by inhibitors of the grb2 sh2-domain

Publications (2)

Publication Number Publication Date
DE60034959D1 true DE60034959D1 (de) 2007-07-05
DE60034959T2 DE60034959T2 (de) 2008-01-17

Family

ID=26857321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034959T Expired - Lifetime DE60034959T2 (de) 1999-10-22 2000-10-20 Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren

Country Status (9)

Country Link
US (1) US7132392B1 (de)
EP (1) EP1223959B1 (de)
JP (1) JP2003512334A (de)
AT (1) ATE362767T1 (de)
AU (1) AU780697B2 (de)
CA (1) CA2387922C (de)
DE (1) DE60034959T2 (de)
ES (1) ES2287048T3 (de)
WO (1) WO2001028577A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
US7425537B2 (en) 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
JP4878730B2 (ja) * 2001-07-18 2012-02-15 株式会社メドジェル Ｈｇｆヒドロゲル徐放性製剤
AU2003279747A1 (en) * 2002-06-28 2004-01-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health A Sh2 domain binding inhibitors
WO2004083865A2 (en) * 2003-03-20 2004-09-30 Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Materials and methods for modulating cell motility
EP2350656B1 (de) * 2008-10-30 2015-01-07 The Translational Genomics Research Institute Verfahren und Kits zur Identifikation invasiver Glioblastome
CN110981938A (zh) * 2019-12-10 2020-04-10 中山大学·深圳 靶向grb2 sh2结合域的抗肿瘤多肽及其应用

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US4879398A (en) 1987-12-31 1989-11-07 Monsanto Company Process for producing 2,6-disubstituted tyrosine
US5182263A (en) 1988-04-25 1993-01-26 Hoffmann-La Roche Inc. Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
US5296608A (en) 1988-04-25 1994-03-22 Hoffman-La Roche Inc. Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides
US5272268A (en) 1990-06-28 1993-12-21 Shionogi & Co., Ltd. Dipeptide derivatives
US5679842A (en) 1990-08-17 1997-10-21 Hoechst Aktiengesellschaft Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids
AU657498B2 (en) 1990-12-14 1995-03-16 Novartis Ag Biphenylyl compounds
DE4115468A1 (de) 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
US5200546A (en) 1991-09-30 1993-04-06 The United States Of America As Represented By The Department Of Health And Human Services Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
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TW399041B (en) 1992-09-09 2000-07-21 Hoechst Ag Substituted cyclohexane derivatives, the preparation and the use for treating diseases
AU5136093A (en) 1992-09-25 1994-04-26 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
US5792771A (en) 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
US5712395A (en) 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5981569A (en) 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
CA2148945A1 (en) 1992-11-18 1994-05-26 Gregory James Wells Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
GB9302331D0 (en) 1993-02-05 1993-03-24 Smithkline Beecham Plc Process
HU219813B (hu) 1993-06-30 2001-08-28 Pharmacia S.P.A. Mitogenezis és motogenezis peptid inhibitorok
US5491253A (en) 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
WO1995011917A1 (en) 1993-10-25 1995-05-04 Parke, Davis & Company Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
US5576323A (en) 1993-12-03 1996-11-19 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2096895A (en) 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US6037134A (en) 1994-03-07 2000-03-14 New York University Medical Center Methods that detect compounds that disrupt receptor tyrosine kinase/GRB-7 complexes
US5580979A (en) 1994-03-15 1996-12-03 Trustees Of Tufts University Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
US5707624A (en) 1994-06-03 1998-01-13 The Regents Of The University Of Michigan Treatment of Kaposi's sarcoma by inhibition of scatter factor
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AU4972096A (en) 1995-02-01 1996-08-21 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains
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Also Published As

Publication number Publication date
WO2001028577A2 (en) 2001-04-26
CA2387922C (en) 2011-12-06
AU2916601A (en) 2001-04-30
EP1223959A2 (de) 2002-07-24
ES2287048T3 (es) 2007-12-16
WO2001028577A3 (en) 2001-12-13
JP2003512334A (ja) 2003-04-02
ATE362767T1 (de) 2007-06-15
US7132392B1 (en) 2006-11-07
CA2387922A1 (en) 2001-04-26
AU780697B2 (en) 2005-04-14
EP1223959B1 (de) 2007-05-23
DE60034959T2 (de) 2008-01-17

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Legal Events

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