JP2003512334A - Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害 - Google Patents

Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害

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Publication number
JP2003512334A
JP2003512334A JP2001531405A JP2001531405A JP2003512334A JP 2003512334 A JP2003512334 A JP 2003512334A JP 2001531405 A JP2001531405 A JP 2001531405A JP 2001531405 A JP2001531405 A JP 2001531405A JP 2003512334 A JP2003512334 A JP 2003512334A
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JP
Japan
Prior art keywords
group
peptide
alkyl
amino
divalent group
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Pending
Application number
JP2001531405A
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English (en)
Japanese (ja)
Other versions
JP2003512334A5 (https=
Inventor
ピー． ボッタロ、ドナルド
エヌ． アタビー、サファイエ
ヴィ． ソリアーノ、ジーザス
イー． ブレッケンリッジ、ダイアン
ヤオ、ツー−ジュン
ガオ、ヤン
アール．ジュニア バーク、テレンス
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Government of the United States of America
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Government of the United States of America
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Filing date
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Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2003512334A publication Critical patent/JP2003512334A/ja
Publication of JP2003512334A5 publication Critical patent/JP2003512334A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2001531405A 1999-10-22 2000-10-20 Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害 Pending JP2003512334A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16089999P 1999-10-22 1999-10-22
US60/160,899 1999-10-22
US22152500P 2000-07-28 2000-07-28
US60/221,525 2000-07-28
PCT/US2000/041423 WO2001028577A2 (en) 1999-10-22 2000-10-20 Inhibition of cell motility and angiogenesis by inhibitors of the grb2 sh2-domain

Publications (2)

Publication Number Publication Date
JP2003512334A true JP2003512334A (ja) 2003-04-02
JP2003512334A5 JP2003512334A5 (https=) 2007-12-20

Family

ID=26857321

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001531405A Pending JP2003512334A (ja) 1999-10-22 2000-10-20 Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害

Country Status (9)

Country Link
US (1) US7132392B1 (https=)
EP (1) EP1223959B1 (https=)
JP (1) JP2003512334A (https=)
AT (1) ATE362767T1 (https=)
AU (1) AU780697B2 (https=)
CA (1) CA2387922C (https=)
DE (1) DE60034959T2 (https=)
ES (1) ES2287048T3 (https=)
WO (1) WO2001028577A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
US7425537B2 (en) 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
WO2004003005A2 (en) * 2002-06-28 2004-01-08 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sh2 domain binding inhibitors
DE60229399D1 (de) * 2001-07-18 2008-11-27 Medgel Corp Hgf-hydrogel-zubereitungen mit verzögerter freisetzung
EP1608983A2 (en) * 2003-03-20 2005-12-28 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Materials and methods for modulating cell motility
EP2350656B1 (en) * 2008-10-30 2015-01-07 The Translational Genomics Research Institute Methods and kits to identify invasive glioblastoma
CN110981938A (zh) * 2019-12-10 2020-04-10 中山大学·深圳 靶向grb2 sh2结合域的抗肿瘤多肽及其应用

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WO1997008193A1 (en) * 1995-08-17 1997-03-06 Novartis Ag Acylated oligopeptide derivatives having cell signal inhibiting activity

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Also Published As

Publication number Publication date
DE60034959T2 (de) 2008-01-17
WO2001028577A2 (en) 2001-04-26
DE60034959D1 (de) 2007-07-05
AU2916601A (en) 2001-04-30
WO2001028577A3 (en) 2001-12-13
US7132392B1 (en) 2006-11-07
CA2387922A1 (en) 2001-04-26
ATE362767T1 (de) 2007-06-15
EP1223959A2 (en) 2002-07-24
CA2387922C (en) 2011-12-06
ES2287048T3 (es) 2007-12-16
AU780697B2 (en) 2005-04-14
EP1223959B1 (en) 2007-05-23

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