DE60034547D1 - Verfahren zur herstellung von hemmern der hmg-coa reduktase - Google Patents

Verfahren zur herstellung von hemmern der hmg-coa reduktase

Info

Publication number
DE60034547D1
DE60034547D1 DE60034547T DE60034547T DE60034547D1 DE 60034547 D1 DE60034547 D1 DE 60034547D1 DE 60034547 T DE60034547 T DE 60034547T DE 60034547 T DE60034547 T DE 60034547T DE 60034547 D1 DE60034547 D1 DE 60034547D1
Authority
DE
Germany
Prior art keywords
compound
substituted
hemmer
hmg
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034547T
Other languages
English (en)
Other versions
DE60034547T2 (de
DE60034547T8 (de
Inventor
Shin-Ichi Hashimoto
Yoshiyuki Yonetani
Akio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of DE60034547D1 publication Critical patent/DE60034547D1/de
Publication of DE60034547T2 publication Critical patent/DE60034547T2/de
Application granted granted Critical
Publication of DE60034547T8 publication Critical patent/DE60034547T8/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60034547T 1999-01-20 2000-01-20 Verfahren zur herstellung von hemmern der hmg-coa reduktase Active DE60034547T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1239299 1999-01-20
JP1239299 1999-01-20
PCT/JP2000/000245 WO2000043533A1 (fr) 1999-01-20 2000-01-20 Procede de production d'inhibiteurs de la hmg coa-reducatase

Publications (3)

Publication Number Publication Date
DE60034547D1 true DE60034547D1 (de) 2007-06-06
DE60034547T2 DE60034547T2 (de) 2008-01-10
DE60034547T8 DE60034547T8 (de) 2008-04-30

Family

ID=11804010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034547T Active DE60034547T8 (de) 1999-01-20 2000-01-20 Verfahren zur herstellung von hemmern der hmg-coa reduktase

Country Status (14)

Country Link
US (1) US6946270B1 (de)
EP (1) EP1146126B1 (de)
JP (1) JP4428866B2 (de)
KR (1) KR100633867B1 (de)
CN (1) CN1240844C (de)
AT (1) ATE360703T1 (de)
AU (1) AU3074300A (de)
CA (1) CA2358927A1 (de)
CZ (1) CZ20012622A3 (de)
DE (1) DE60034547T8 (de)
HK (1) HK1040419B (de)
HU (1) HUP0105000A3 (de)
IL (1) IL144405A0 (de)
WO (1) WO2000043533A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0105145A3 (en) 1999-01-29 2006-02-28 Kyowa Hakko Kogyo Kk Process for producing hmg-coa reductase inhibitor
CN101351551A (zh) 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
JP2010512733A (ja) * 2006-12-13 2010-04-30 ディーエスエム アイピー アセッツ ビー．ブイ． プラバスタチンを調製するための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750894A (en) 1980-09-08 1982-03-25 Sankyo Co Ltd Preparation of ml-236b derivative
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP2672551B2 (ja) 1987-03-02 1997-11-05 三共株式会社 チトクロームｐ−４５０遺伝子を含有するｄｎａ
US6043064A (en) 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
DE69839248T2 (de) * 1997-08-07 2009-04-02 Kyowa Hakko Kogyo Co., Ltd. VERFAHREN FÜR DIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE.
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
HUP0105145A3 (en) 1999-01-29 2006-02-28 Kyowa Hakko Kogyo Kk Process for producing hmg-coa reductase inhibitor

Also Published As

Publication number Publication date
HUP0105000A3 (en) 2004-03-01
AU3074300A (en) 2000-08-07
KR20020002375A (ko) 2002-01-09
CN1344328A (zh) 2002-04-10
DE60034547T2 (de) 2008-01-10
CA2358927A1 (en) 2000-07-27
HUP0105000A2 (hu) 2002-04-29
EP1146126B1 (de) 2007-04-25
ATE360703T1 (de) 2007-05-15
CN1240844C (zh) 2006-02-08
IL144405A0 (en) 2002-05-23
HK1040419B (zh) 2007-12-14
DE60034547T8 (de) 2008-04-30
CZ20012622A3 (cs) 2002-01-16
HK1040419A1 (en) 2002-06-07
WO2000043533A1 (fr) 2000-07-27
JP4428866B2 (ja) 2010-03-10
EP1146126A4 (de) 2004-05-19
US6946270B1 (en) 2005-09-20
EP1146126A1 (de) 2001-10-17
KR100633867B1 (ko) 2006-10-16

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: KYOWA HAKKO BIO CO., LTD., TOKYO, JP