DE60028066D1 - Lentivirale vektoren für die herstellung von immunotherapeutischen zusammensetzungen - Google Patents
Lentivirale vektoren für die herstellung von immunotherapeutischen zusammensetzungenInfo
- Publication number
- DE60028066D1 DE60028066D1 DE60028066T DE60028066T DE60028066D1 DE 60028066 D1 DE60028066 D1 DE 60028066D1 DE 60028066 T DE60028066 T DE 60028066T DE 60028066 T DE60028066 T DE 60028066T DE 60028066 D1 DE60028066 D1 DE 60028066D1
- Authority
- DE
- Germany
- Prior art keywords
- retroviral
- response
- vector
- immunotherapeic
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013598 vector Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 108700019146 Transgenes Proteins 0.000 abstract 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 2
- 230000001177 retroviral effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/867—Retroviral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99402492 | 1999-10-11 | ||
EP99402492A EP1092779B1 (de) | 1999-10-11 | 1999-10-11 | Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen |
PCT/EP2000/010419 WO2001027300A1 (en) | 1999-10-11 | 2000-10-10 | Lentiviral vectors for the preparation of immunotherapeutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60028066D1 true DE60028066D1 (de) | 2006-06-22 |
DE60028066T2 DE60028066T2 (de) | 2007-01-18 |
Family
ID=8242139
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941703T Expired - Lifetime DE69941703D1 (de) | 1999-10-11 | 1999-10-11 | Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen |
DE60028066T Expired - Lifetime DE60028066T2 (de) | 1999-10-11 | 2000-10-10 | Lentivirale vektoren für die herstellung von immunotherapeutischen zusammensetzungen |
DE60042903T Expired - Lifetime DE60042903D1 (de) | 1999-10-11 | 2000-10-10 | Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941703T Expired - Lifetime DE69941703D1 (de) | 1999-10-11 | 1999-10-11 | Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60042903T Expired - Lifetime DE60042903D1 (de) | 1999-10-11 | 2000-10-10 | Lentivirale Vektoren für die Herstellung von immunotherapeutischen Zusammensetzungen |
Country Status (15)
Country | Link |
---|---|
US (3) | US7968332B2 (de) |
EP (4) | EP2169073B1 (de) |
JP (2) | JP4663943B2 (de) |
CN (2) | CN1379820B (de) |
AT (3) | ATE449858T1 (de) |
AU (3) | AU785060B2 (de) |
CA (1) | CA2387182C (de) |
CY (4) | CY1105149T1 (de) |
DE (3) | DE69941703D1 (de) |
DK (4) | DK1092779T3 (de) |
ES (4) | ES2447115T3 (de) |
HK (2) | HK1093523A1 (de) |
IL (2) | IL148901A0 (de) |
PT (4) | PT2169073E (de) |
WO (1) | WO2001027300A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
ES2447115T3 (es) | 1999-10-11 | 2014-03-11 | Institut Pasteur | Vectores para la preparación de composiciones inmunoterapéuticas |
DK1224314T3 (da) | 1999-10-12 | 2007-05-21 | Inst Nat Sante Rech Med | Lentiviralt triplex-DNA samt vektorer og rekombinante celler indeholder lentiviralt triplex-DNA |
US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
EP1412493B1 (de) | 2001-08-02 | 2011-10-05 | Institut Clayton De La Recherche | Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor-produktionssystemen |
EP1438075A4 (de) | 2001-10-02 | 2006-04-19 | Inst Clayton De La Rech | Verfahren und zusammensetzungen in verbindung mit lentiviralen vektoren mit begrenzter expression und ihre anwendungen |
FR2870126B1 (fr) * | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
EP1712241A1 (de) | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Intratumoral applizierbare Zusammensetzung zur Krebsbehandlung |
US8222029B2 (en) | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
US8158413B2 (en) * | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
EP1739092A1 (de) | 2005-06-28 | 2007-01-03 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Peptidische Antagonisten von Klasse III Semaphorin/Neuropilin Komplexen |
EP1748067A1 (de) | 2005-07-29 | 2007-01-31 | Institut Pasteur | Polynukleotide, die für MHC Klasse I-beschränkte Epitope der hTERT, Analoge und Polyepitope kodieren |
WO2007054814A1 (en) | 2005-11-14 | 2007-05-18 | Centre National De La Recherche Scientifique - Cnrs | Inhibitors of parp activity and uses thereof |
EP3293266A1 (de) | 2007-05-04 | 2018-03-14 | University Health Network | Il-12-immuntherapie gegen krebs |
CN102083462B (zh) * | 2007-08-03 | 2015-02-18 | 巴斯德研究院 | 慢病毒基因转移载体及其医学应用 |
EP2385107B1 (de) | 2010-05-03 | 2016-08-24 | Institut Pasteur | Auf Lentivirusvektor basierende immunologische Verbindungen gegen Malaria |
EP2666477A1 (de) | 2012-05-23 | 2013-11-27 | Theravectys | Lentivirale Vektoren mit einem MHC-Klasse-I-Promotor |
CA2819552C (en) | 2010-12-09 | 2023-09-26 | Institut Pasteur | Mgmt-based method for obtaining high yield of recombinant protein expression |
NO2788478T3 (de) | 2011-12-09 | 2018-01-20 | ||
US20150182617A1 (en) | 2012-07-25 | 2015-07-02 | Theravectys | Glycoproteins for pseudotyping lentivectors |
WO2015063707A1 (en) | 2013-10-31 | 2015-05-07 | Theravectys | LENTIVIRAL VECTORS FOR INDUCING CD4+ and CD8+ IMMUNE RESPONSES IN VACCINATION OF HUMANS |
EP3009144A1 (de) | 2014-10-15 | 2016-04-20 | Theravectys | Lentivirale Vektoren zur Induzierung von CD4+- und+CD8+-Immunreaktionen bei der Impfung von Menschen |
EP3087188A1 (de) | 2013-12-23 | 2016-11-02 | Theravectys | Lyophilisierte lentiviren-vektor-partikel, zusammensetzungen daraus und verfahren |
CN106163552A (zh) | 2014-01-27 | 2016-11-23 | 赛拉福柯蒂斯公司 | 用于产生针对人嗜t‑淋巴病毒1型的免疫应答的慢病毒载体 |
GB201408255D0 (en) * | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
EP3511413B1 (de) | 2014-07-25 | 2022-09-07 | Theravectys | Lentivirale vektoren zur regulierten expression eines chimären antigenrezeptormoleküls |
EP3031923A1 (de) | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentivirale, vektorbasierte immunogene Zusammensetzung gegen Japanische Enzephalitis |
EP3410849B1 (de) | 2016-02-05 | 2023-07-05 | Institut Pasteur | Verwendung von inhibitoren von adam12 als adjuvanzien in tumortherapien |
EP3211003A1 (de) | 2016-02-24 | 2017-08-30 | Institut Pasteur | T-zell-rezeptoren aus dem hiv-spezifischen repertoire, mittel zu deren herstellung und therapeutische verwendung davon |
EP3276006A1 (de) | 2016-07-27 | 2018-01-31 | Theravectys | Lentivirale vektoren zur expression von hepatitis-b-virus (hbv)-antigenen |
EP3357506A1 (de) | 2017-02-02 | 2018-08-08 | Institut Pasteur | Mehrere malaria-prä-erythrozyten-antigene und deren verwendung bei der auslösung einer schützenden immunantwort in einem wirt |
EP3357504A1 (de) | 2017-02-02 | 2018-08-08 | Institut Pasteur | Funktionelles screening von antigenen polypeptiden verwendung zur identifizierung von antigenen zur anregung einer schützenden immunantwort und zur auswahl von antigenen mit optimaler schutzwirkung |
EP3648776A4 (de) | 2017-07-06 | 2021-04-07 | The Medical College of Wisconsin, Inc. | Neue in-vitro- und in-vivo-anreichungsstrategie gegen lymphozyten aus vektortransduzierten hsc zur behandlung von erkrankungen |
EP3697809A1 (de) | 2017-10-20 | 2020-08-26 | Institut Curie | Für rush angepasste dap10/12-basierte cars |
US20200283485A1 (en) | 2017-10-20 | 2020-09-10 | Institut Curie | Hook fusion protein for regulating the cellular trafficking of a target protein |
CN108118070A (zh) * | 2018-01-15 | 2018-06-05 | 南京驯鹿医疗技术有限公司 | 一种慢病毒制备方法 |
CN108588028B (zh) * | 2018-04-26 | 2021-11-09 | 中国人民解放军军事科学院军事医学研究院 | 一种靶向cdkn2a的cic细胞模型及其制备方法 |
WO2020229893A1 (en) | 2019-05-10 | 2020-11-19 | Institut Pasteur | Live imaging system to visualize the retro-transcribed viral dna genome |
CA3182333A1 (en) | 2020-05-20 | 2021-11-25 | Institut Curie | Single domain antibodies and their use in cancer therapies |
WO2022013405A1 (en) | 2020-07-15 | 2022-01-20 | Institut Pasteur | Sars-cov-2 immunogenic compositions, vaccines, and methods |
CN117120085A (zh) | 2020-07-15 | 2023-11-24 | 巴斯德研究所 | Sars-cov-2免疫原性组合物、疫苗和方法 |
WO2022167831A1 (en) | 2021-02-02 | 2022-08-11 | Institut Pasteur | Sars-cov-2 immunogenic compositions, vaccines, and methods |
GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
US20240053339A1 (en) | 2020-09-21 | 2024-02-15 | Theravectys | High throughput methods and products for sars-cov-2 sero-neutralization assay |
EP4225382A2 (de) | 2020-10-07 | 2023-08-16 | Asklepios Biopharmaceutical, Inc. | Therapeutische adeno-assoziierte virusverabreichung von fkutin-verwandtem protein (fkrp) zur behandlung von dystroglycanopathie. erkrankungen mit gliedmassengürtel 21 |
EP3984548A1 (de) | 2020-10-16 | 2022-04-20 | Institut Pasteur | Generation von lentiviralen vektoren, die es ermöglichen, antigene zum mhc-ii-weg zu leiten und cd4+- und cd8+-t-zellantworten als immunantwort in einem wirt zu induzieren |
EP4229090A1 (de) | 2020-10-16 | 2023-08-23 | Université d'Aix-Marseille | Anti-gpc4-einzeldomänenantikörper |
IL304031A (en) | 2021-01-14 | 2023-08-01 | Inst Curie | Variants of single-domain HER2 antibodies and their chimeric antigenic receptors |
CN116981777A (zh) | 2021-03-12 | 2023-10-31 | 巴斯德研究所 | 靶向mhc-ii途径抗原并在宿主中诱导保护性cd8+和cd4+t细胞免疫的慢病毒载体 |
AU2022386715A1 (en) | 2021-11-15 | 2024-05-16 | Institut Pasteur | Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers |
WO2024023135A1 (en) | 2022-07-27 | 2024-02-01 | Theravectys | Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers |
WO2024084041A2 (en) | 2022-10-21 | 2024-04-25 | Institut Pasteur | Polynucleotides and lentiviral vectors expressing non-structural antigens of a flavivirus selected from the group of denv, zikv and yfv, inducing protective cd8+ t-cell immunity in a host |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH684094A5 (de) * | 1988-03-21 | 1994-07-15 | Viagene Inc | Rekombinante Retroviren. |
GB9213559D0 (en) * | 1992-06-25 | 1992-08-12 | Smithkline Beecham Biolog | Vaccines |
JPH06261764A (ja) | 1993-02-17 | 1994-09-20 | Wisconsin Alumni Res Found | 混合型ltr含有超複合型レトロウイルス及びその使用方法 |
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1999
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