ATE243747T1 - Herstellung von antikörpern - Google Patents
Herstellung von antikörpernInfo
- Publication number
- ATE243747T1 ATE243747T1 AT92306420T AT92306420T ATE243747T1 AT E243747 T1 ATE243747 T1 AT E243747T1 AT 92306420 T AT92306420 T AT 92306420T AT 92306420 T AT92306420 T AT 92306420T AT E243747 T1 ATE243747 T1 AT E243747T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- production
- same
- recombinant
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1009—Picornaviridae, e.g. hepatitis A virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919115284A GB9115284D0 (en) | 1991-07-15 | 1991-07-15 | Production of antibodies |
| GB919116594A GB9116594D0 (en) | 1991-08-01 | 1991-08-01 | Production of antibodies |
| GB929206284A GB9206284D0 (en) | 1992-03-23 | 1992-03-23 | Production of antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE243747T1 true ATE243747T1 (de) | 2003-07-15 |
Family
ID=27265765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92306420T ATE243747T1 (de) | 1991-07-15 | 1992-07-14 | Herstellung von antikörpern |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5876961A (de) |
| EP (1) | EP0523949B1 (de) |
| JP (1) | JP3502093B2 (de) |
| KR (1) | KR100255717B1 (de) |
| AT (1) | ATE243747T1 (de) |
| AU (1) | AU662752B2 (de) |
| CA (1) | CA2111858A1 (de) |
| DE (1) | DE69233104T2 (de) |
| ES (1) | ES2199216T3 (de) |
| FI (1) | FI940144L (de) |
| HU (1) | HU220355B (de) |
| IE (1) | IE922287A1 (de) |
| IL (1) | IL102490A0 (de) |
| NZ (1) | NZ243558A (de) |
| TW (1) | TW373023B (de) |
| WO (1) | WO1993002190A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| EP0605442B1 (de) * | 1991-07-25 | 2003-04-16 | Idec Pharmaceuticals Corporation | Rekombinante antikörper zur humanen therapie |
| US5756096A (en) * | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| US20020122807A1 (en) * | 1998-07-07 | 2002-09-05 | Dan Michael D. | Antigen binding fragments, designated 4B5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers |
| US20030180284A1 (en) * | 1998-11-05 | 2003-09-25 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
| ATE414151T1 (de) | 2000-03-03 | 2008-11-15 | Cambridge Antibody Tech | Antikörper gegen eotaxin und deren verwendung |
| US6946546B2 (en) | 2000-03-06 | 2005-09-20 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| US20040253242A1 (en) * | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
| ES2258558T3 (es) * | 2000-12-05 | 2006-09-01 | Alexion Pharmaceuticals, Inc. | Anticuerpos diseñados racionalmente. |
| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| CN105884893A (zh) | 2002-07-18 | 2016-08-24 | 莫鲁斯有限公司 | 抗体混合物的重组生产 |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| CA2554054C (en) | 2004-01-20 | 2013-06-04 | Merus B.V. | Mixtures of binding proteins |
| WO2006014498A2 (en) * | 2004-07-06 | 2006-02-09 | Bioren, Inc. | Universal antibody libraries |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| ITRM20050297A1 (it) * | 2005-06-08 | 2006-12-09 | Univ Siena | Anticorpi diretti contro la proteina basica della mielina che riconoscono un epitopo del cd64 e uso di essi come immunodepressivi. |
| CN103276033A (zh) | 2006-09-13 | 2013-09-04 | 雅培制药有限公司 | 细胞培养改良 |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| WO2008094316A2 (en) | 2006-09-22 | 2008-08-07 | Stowers Institute Of Medical Research | Novel branchiostoma derived fluorescent proteins |
| EP2098536A1 (de) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine |
| ES2667493T3 (es) | 2008-11-14 | 2018-05-11 | Viacyte, Inc. | Encapsulación de células pancreáticas derivadas de células madre humanas pluripotentes |
| US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| US10585098B2 (en) | 2009-11-23 | 2020-03-10 | The Johns Hopkins University | Optimizing diagnostics for galactofuranose containing antigens |
| WO2011063395A2 (en) | 2009-11-23 | 2011-05-26 | The Johns Hopkins University | Lateral flow device for diagnosing microbial infections |
| EP2702077A2 (de) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen |
| CA2831572C (en) | 2011-05-02 | 2019-11-26 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| PT2838917T (pt) | 2012-04-20 | 2019-09-12 | Merus Nv | Métodos e meios para a produção de moléculas similares a ig heterodiméricas |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| SG11201408646VA (en) | 2012-07-06 | 2015-01-29 | Genmab Bv | Dimeric protein with triple mutations |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
| PL2900694T3 (pl) | 2012-09-27 | 2018-12-31 | Merus N.V. | Dwuswoiste przeciwciała igg jako aktywatory komórek t |
| EP2830651A4 (de) | 2013-03-12 | 2015-09-02 | Abbvie Inc | An humanes tnf-alpha bindende humane antikörper und verfahren zur herstellung davon |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| JP6205175B2 (ja) | 2013-05-16 | 2017-10-04 | 株式会社Resvo | 精神・神経疾患バイオマーカー |
| EP3052640A2 (de) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| US10107822B2 (en) | 2013-12-16 | 2018-10-23 | The Johns Hopkins University | Interferon-gamma release assays for diagnosis of invasive fungal infections |
| ES2816624T3 (es) | 2014-02-28 | 2021-04-05 | Merus Nv | Anticuerpos que se unen a EGFR y ERBB3 |
| RS66392B1 (sr) | 2014-02-28 | 2025-02-28 | Merus Nv | Antitelo koje vezuje erbb-2 i erbb-3 |
| LT3115376T (lt) | 2015-07-10 | 2018-11-12 | Merus N.V. | Antikūnai, kurie jungiasi su žmogaus cd3 |
| US11939394B2 (en) | 2015-10-23 | 2024-03-26 | Merus N.V. | Binding molecules that inhibit cancer growth |
| IL269656B2 (en) | 2017-03-31 | 2024-06-01 | Merus Nv | Bispecific antibodies that bind ERBB-2 and ERBB3 for use in the treatment of cells with NRG1 fusion gene |
| EP3606964A4 (de) | 2017-04-03 | 2020-12-09 | Immunomedics, Inc. | Subkutane verabreichung von antikörper-arzneimittelkonjugaten zur krebstherapie |
| EP3625264B9 (de) | 2017-05-17 | 2023-10-25 | Merus N.V. | Kombination eines erbb-2 / erbb-3-bispezifischen antikörpers mit endokrin-therapie für brustkrebs |
| PL3665198T3 (pl) | 2017-08-09 | 2025-06-09 | Merus N.V. | Przeciwciała wiążące egfr i cmet |
| EP3693013A4 (de) | 2017-10-06 | 2021-06-30 | Ono Pharmaceutical Co., Ltd. | Bispezifischer antikörper |
| TWI804572B (zh) | 2018-02-09 | 2023-06-11 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| TW202509079A (zh) | 2019-04-04 | 2025-03-01 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| US20220372148A1 (en) | 2019-07-05 | 2022-11-24 | Ono Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating hematological cancer |
| CA3149309A1 (en) | 2019-07-30 | 2021-02-04 | Ono Pharmaceutical Co., Ltd. | Bispecific antibody |
| WO2021025140A1 (ja) | 2019-08-08 | 2021-02-11 | 小野薬品工業株式会社 | 二重特異性タンパク質 |
| KR20250052397A (ko) | 2022-08-23 | 2025-04-18 | 오노 야꾸힝 고교 가부시키가이샤 | 이중 특이성 항체 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296024A (en) * | 1974-12-09 | 1981-10-20 | Merck & Co., Inc. | Human immune serum globulin with high hepatitis A antibody titer |
| US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
| CH652145A5 (de) * | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| JPS6054687A (ja) * | 1983-07-19 | 1985-03-29 | スロ−ン−ケツタリング インステイテユ−ト フオ− キヤンサ− リサ−チ | ヒト モノクロ−ン抗体の製法 |
| US4777245A (en) | 1984-01-06 | 1988-10-11 | Genelabs Incorporated | Non-human primate monoclonal antibodies and methods |
| US4997764A (en) * | 1987-04-23 | 1991-03-05 | New York University | Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors |
| WO1989000607A1 (en) * | 1987-07-09 | 1989-01-26 | The United States Of America, As Represented By Th | Preparation of human monoclonal antibodies of selected specificity and isotypes |
| NZ226694A (en) * | 1987-10-28 | 1994-04-27 | Oncogen | Human immunoglobulin produced by recombinant dna techniques |
| HU218093B (hu) * | 1988-10-19 | 2000-05-28 | Dow Chemical Co. | Rák kezelésére alkalmazható, nagy affinitású, módosított antitestek új csoportja, eljárás előállítására, valamint az antitesteket tartalmazó konjugátumok és készítmények |
| DE3921211C1 (de) * | 1989-06-28 | 1990-11-29 | Idt Ag Fuer In Vivo Diagnostik Und Therapie, Zuerich, Ch | |
| WO1991004336A1 (en) * | 1989-09-19 | 1991-04-04 | Centocor, Inc. | Method for improving human monoclonal antibody production |
| GB8925590D0 (en) * | 1989-11-13 | 1990-01-04 | Central Blood Lab Authority | Monoclonal antibodies |
| DE4002897A1 (de) * | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
| ES2336444T3 (es) * | 1990-02-01 | 2010-04-13 | Siemens Healthcare Diagnostics Products Gmbh | Obtencion y empleo de ginotecas de anticuerpos humanos ("bancos de anticuerpos humanos"). |
| EP0605442B1 (de) * | 1991-07-25 | 2003-04-16 | Idec Pharmaceuticals Corporation | Rekombinante antikörper zur humanen therapie |
-
1992
- 1992-07-14 DE DE69233104T patent/DE69233104T2/de not_active Revoked
- 1992-07-14 TW TW081105557A patent/TW373023B/zh active
- 1992-07-14 WO PCT/GB1992/001282 patent/WO1993002190A1/en not_active Ceased
- 1992-07-14 ES ES92306420T patent/ES2199216T3/es not_active Expired - Lifetime
- 1992-07-14 NZ NZ243558A patent/NZ243558A/en unknown
- 1992-07-14 CA CA002111858A patent/CA2111858A1/en not_active Abandoned
- 1992-07-14 KR KR1019940700121A patent/KR100255717B1/ko not_active Expired - Fee Related
- 1992-07-14 HU HU9400110A patent/HU220355B/hu not_active IP Right Cessation
- 1992-07-14 EP EP92306420A patent/EP0523949B1/de not_active Revoked
- 1992-07-14 JP JP50245793A patent/JP3502093B2/ja not_active Expired - Lifetime
- 1992-07-14 IL IL102490A patent/IL102490A0/xx unknown
- 1992-07-14 AU AU22798/92A patent/AU662752B2/en not_active Ceased
- 1992-07-14 FI FI940144A patent/FI940144L/fi unknown
- 1992-07-14 IE IE228792A patent/IE922287A1/en not_active Application Discontinuation
- 1992-07-14 AT AT92306420T patent/ATE243747T1/de not_active IP Right Cessation
-
1995
- 1995-01-26 US US08/378,939 patent/US5876961A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69233104D1 (de) | 2003-07-31 |
| JPH07502882A (ja) | 1995-03-30 |
| JP3502093B2 (ja) | 2004-03-02 |
| ES2199216T3 (es) | 2004-02-16 |
| FI940144A0 (fi) | 1994-01-12 |
| FI940144A7 (fi) | 1994-01-12 |
| FI940144L (fi) | 1994-01-12 |
| AU662752B2 (en) | 1995-09-14 |
| IL102490A0 (en) | 1993-01-14 |
| IE922287A1 (en) | 1993-01-27 |
| HU9400110D0 (en) | 1994-05-30 |
| EP0523949B1 (de) | 2003-06-25 |
| HUT69798A (en) | 1995-09-28 |
| NZ243558A (en) | 1994-06-27 |
| KR100255717B1 (ko) | 2000-05-01 |
| AU2279892A (en) | 1993-02-23 |
| WO1993002190A1 (en) | 1993-02-04 |
| EP0523949A1 (de) | 1993-01-20 |
| DE69233104T2 (de) | 2004-05-13 |
| US5876961A (en) | 1999-03-02 |
| HU220355B (hu) | 2001-12-28 |
| TW373023B (en) | 1999-11-01 |
| CA2111858A1 (en) | 1993-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |