DE60027301T2 - Zweikomponentenzusammensetzungen zur kosmetischen oder pharmazeutischen verwendung - Google Patents
Zweikomponentenzusammensetzungen zur kosmetischen oder pharmazeutischen verwendung Download PDFInfo
- Publication number
- DE60027301T2 DE60027301T2 DE60027301T DE60027301T DE60027301T2 DE 60027301 T2 DE60027301 T2 DE 60027301T2 DE 60027301 T DE60027301 T DE 60027301T DE 60027301 T DE60027301 T DE 60027301T DE 60027301 T2 DE60027301 T2 DE 60027301T2
- Authority
- DE
- Germany
- Prior art keywords
- phase
- ascorbic acid
- composition according
- amount
- ceramides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 45
- 239000002537 cosmetic Substances 0.000 title claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 32
- 239000003963 antioxidant agent Substances 0.000 claims description 20
- 235000006708 antioxidants Nutrition 0.000 claims description 20
- 235000010323 ascorbic acid Nutrition 0.000 claims description 15
- 239000011668 ascorbic acid Substances 0.000 claims description 15
- 229960005070 ascorbic acid Drugs 0.000 claims description 15
- 229940106189 ceramide Drugs 0.000 claims description 13
- 150000001783 ceramides Chemical class 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- 102100033663 Transforming growth factor beta receptor type 3 Human genes 0.000 claims description 10
- 108010079292 betaglycan Proteins 0.000 claims description 10
- 239000002955 immunomodulating agent Substances 0.000 claims description 9
- 229940121354 immunomodulator Drugs 0.000 claims description 9
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- 239000004909 Moisturizer Substances 0.000 claims description 7
- 230000001333 moisturizer Effects 0.000 claims description 7
- 230000002584 immunomodulator Effects 0.000 claims description 6
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 229920002770 condensed tannin Polymers 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical group OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 229940087559 grape seed Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 description 10
- 230000006872 improvement Effects 0.000 description 10
- 230000008901 benefit Effects 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 230000003244 pro-oxidative effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 206010040954 Skin wrinkling Diseases 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9902972-3A BR9902972B1 (pt) | 1999-07-16 | 1999-07-16 | composição bifásica de uso cosmético ou farmacêutico. |
| BR9902972 | 1999-07-16 | ||
| PCT/BR2000/000077 WO2001005357A1 (en) | 1999-07-16 | 2000-07-14 | Two-component composition for cosmetic or pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60027301D1 DE60027301D1 (de) | 2006-05-24 |
| DE60027301T2 true DE60027301T2 (de) | 2007-03-29 |
Family
ID=36178416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60027301T Expired - Lifetime DE60027301T2 (de) | 1999-07-16 | 2000-07-14 | Zweikomponentenzusammensetzungen zur kosmetischen oder pharmazeutischen verwendung |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1200040B8 (enExample) |
| JP (1) | JP4176992B2 (enExample) |
| AR (1) | AR025204A1 (enExample) |
| AT (1) | ATE322880T1 (enExample) |
| BR (1) | BR9902972B1 (enExample) |
| CA (1) | CA2379508C (enExample) |
| CO (1) | CO5271721A1 (enExample) |
| DE (1) | DE60027301T2 (enExample) |
| ES (1) | ES2262527T3 (enExample) |
| MX (1) | MXPA00006890A (enExample) |
| PE (1) | PE20010163A1 (enExample) |
| WO (1) | WO2001005357A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0003166B1 (pt) | 1999-07-16 | 2015-08-25 | Natura Cosmeticos Sa | Processo para estabilização de compostos antioxidantes, e composições aquosas |
| US20060293258A1 (en) * | 2005-06-23 | 2006-12-28 | Peter Rohdewald | Method and composition to treat skin ulcers |
| JPWO2007004300A1 (ja) * | 2005-07-06 | 2009-01-22 | 株式会社ドクターシーラボ | 化粧品 |
| ES2487290T3 (es) | 2012-03-20 | 2014-08-20 | Sociedad Anónima Minera Catalano-Aragonesa | Envase multicapa opaco |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5094783A (en) * | 1990-06-29 | 1992-03-10 | Uab Research Foundation | Retinoid compounds |
| US5626883A (en) * | 1994-04-15 | 1997-05-06 | Metagenics, Inc. | Ascorbic acid compositions providing enhanced human immune system activity |
| US5804168A (en) * | 1997-01-29 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for protecting and treating sun damaged skin |
| US5902591A (en) * | 1997-04-03 | 1999-05-11 | La Prairie Sa | Stable topical cosmetic/pharmaceutical emulsion compositions containing ascorbic acid |
| AU1944599A (en) * | 1997-12-24 | 1999-07-19 | Shaklee Corporation | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
-
1999
- 1999-07-16 BR BRPI9902972-3A patent/BR9902972B1/pt not_active IP Right Cessation
-
2000
- 2000-07-07 PE PE2000000683A patent/PE20010163A1/es not_active Application Discontinuation
- 2000-07-13 MX MXPA00006890A patent/MXPA00006890A/es active IP Right Grant
- 2000-07-14 WO PCT/BR2000/000077 patent/WO2001005357A1/en not_active Ceased
- 2000-07-14 EP EP00947695A patent/EP1200040B8/en not_active Expired - Lifetime
- 2000-07-14 CO CO00053357A patent/CO5271721A1/es not_active Application Discontinuation
- 2000-07-14 AT AT00947695T patent/ATE322880T1/de not_active IP Right Cessation
- 2000-07-14 ES ES00947695T patent/ES2262527T3/es not_active Expired - Lifetime
- 2000-07-14 CA CA2379508A patent/CA2379508C/en not_active Expired - Fee Related
- 2000-07-14 AR ARP000103633A patent/AR025204A1/es not_active Application Discontinuation
- 2000-07-14 DE DE60027301T patent/DE60027301T2/de not_active Expired - Lifetime
- 2000-07-14 JP JP2001510415A patent/JP4176992B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CO5271721A1 (es) | 2003-04-30 |
| ATE322880T1 (de) | 2006-04-15 |
| JP4176992B2 (ja) | 2008-11-05 |
| JP2003504385A (ja) | 2003-02-04 |
| AR025204A1 (es) | 2002-11-13 |
| MXPA00006890A (es) | 2005-04-19 |
| BR9902972A (pt) | 2001-03-06 |
| DE60027301D1 (de) | 2006-05-24 |
| BR9902972B1 (pt) | 2012-02-22 |
| CA2379508C (en) | 2011-03-29 |
| EP1200040A1 (en) | 2002-05-02 |
| PE20010163A1 (es) | 2001-03-29 |
| ES2262527T3 (es) | 2006-12-01 |
| WO2001005357A1 (en) | 2001-01-25 |
| EP1200040B8 (en) | 2006-09-13 |
| EP1200040B1 (en) | 2006-04-12 |
| CA2379508A1 (en) | 2001-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |