DE60018215T2 - Verbindungen und verfahren zur modulation von estrogen rezeptoren - Google Patents
Verbindungen und verfahren zur modulation von estrogen rezeptoren Download PDFInfo
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- DE60018215T2 DE60018215T2 DE60018215T DE60018215T DE60018215T2 DE 60018215 T2 DE60018215 T2 DE 60018215T2 DE 60018215 T DE60018215 T DE 60018215T DE 60018215 T DE60018215 T DE 60018215T DE 60018215 T2 DE60018215 T2 DE 60018215T2
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US47577699A | 1999-12-30 | 1999-12-30 | |
| US475776 | 1999-12-30 | ||
| US09/492,939 US6291456B1 (en) | 1998-12-30 | 2000-01-27 | Compounds and methods for modulation of estrogen receptors |
| US492939 | 2000-01-27 | ||
| US611156 | 2000-07-06 | ||
| US09/611,156 US6331562B1 (en) | 1998-12-30 | 2000-07-06 | Compounds and methods for modulation of estrogen receptors |
| PCT/US2000/035671 WO2001049673A2 (en) | 1999-12-30 | 2000-12-29 | Compounds and methods for modulation of estrogen receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60018215D1 DE60018215D1 (de) | 2005-03-24 |
| DE60018215T2 true DE60018215T2 (de) | 2006-02-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE60018215T Expired - Fee Related DE60018215T2 (de) | 1999-12-30 | 2000-12-29 | Verbindungen und verfahren zur modulation von estrogen rezeptoren |
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| EP (1) | EP1246814B1 (enExample) |
| JP (1) | JP2003519219A (enExample) |
| KR (1) | KR20020075388A (enExample) |
| CN (1) | CN1281598C (enExample) |
| AT (1) | ATE289300T1 (enExample) |
| AU (1) | AU781282B2 (enExample) |
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| ES (1) | ES2238034T3 (enExample) |
| IL (1) | IL150463A0 (enExample) |
| PT (1) | PT1246814E (enExample) |
| WO (1) | WO2001049673A2 (enExample) |
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| CO5271709A1 (es) * | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos |
| EP1177787A3 (en) * | 2000-07-28 | 2003-09-10 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating cataracts |
| EP1281710A1 (en) * | 2001-08-03 | 2003-02-05 | CHIESI FARMACEUTICI S.p.A. | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
| US7148252B2 (en) * | 2001-10-03 | 2006-12-12 | Signal Pharmaceuticals, Llc | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis |
| US7217734B2 (en) | 2001-11-19 | 2007-05-15 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| US7524866B2 (en) | 2001-11-29 | 2009-04-28 | Gtx, Inc. | Prevention and treatment of androgen—deprivation induced osteoporosis |
| WO2003047504A2 (en) * | 2001-11-29 | 2003-06-12 | Gtx Inc. | Prevention and treatment of androgen-deprivation induced osteoporosis |
| AU2005202072B2 (en) * | 2001-11-29 | 2008-10-23 | Gtx, Inc. | Prevention and treatment of androgen-deprivation induced conditions |
| AU2003239155B2 (en) * | 2002-04-19 | 2008-12-04 | Novartis Ag | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| US7091235B2 (en) | 2002-10-15 | 2006-08-15 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
| US7674783B2 (en) * | 2002-11-22 | 2010-03-09 | Dimera Inc. | Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease |
| MXPA05011243A (es) | 2003-04-21 | 2005-12-15 | Lilly Co Eli | Benzopiranos substituidos como agonistas selectivos del receptor beta de estrogeno. |
| ES2338119T3 (es) | 2003-04-21 | 2010-05-04 | Eli Lilly And Company | Benzopiranos sustituidos como agonistas selectivos del receptor-beta de estrogeno. |
| US7098340B2 (en) * | 2003-05-14 | 2006-08-29 | Warner Lambert Company Llc | Benzyl sulfonamide derivatives |
| WO2005028472A1 (en) * | 2003-09-15 | 2005-03-31 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| CA2595472A1 (en) * | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel coumarin derivatives as ion channel openers |
| WO2008002490A2 (en) * | 2006-06-23 | 2008-01-03 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| PL2568806T3 (pl) | 2010-05-12 | 2017-03-31 | Radius Health, Inc. | Schematy lecznicze |
| EP2621901B1 (en) | 2010-09-28 | 2015-07-29 | Radius Health, Inc | Selective androgen receptor modulators |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| SI3122426T1 (sl) | 2014-03-28 | 2023-04-28 | Duke University | Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev |
| CN105801544A (zh) * | 2016-04-18 | 2016-07-27 | 中国药科大学 | 3-芳基-4-芳香胺-香豆素衍生物及其制备方法和医药用途 |
| CN105801543B (zh) * | 2016-04-18 | 2019-08-02 | 中国药科大学 | 4-芳香胺-香豆素衍生物及其制备方法和医药用途 |
| PT3474841T (pt) | 2016-06-22 | 2022-06-20 | Radius Health Inc | Métodos de tratamento do cancro de mama ar+ |
| CN106492204A (zh) * | 2016-12-27 | 2017-03-15 | 郑州郑先医药科技有限公司 | 一种治疗白内障的药物组合物 |
| CN106727637A (zh) * | 2016-12-27 | 2017-05-31 | 郑州郑先医药科技有限公司 | 一种治疗白内障的西药组合物及其用途 |
| EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
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| US5883118A (en) * | 1996-01-11 | 1999-03-16 | Nova Nordisk A/S | Prostatic carcinoma |
| US5726202A (en) * | 1996-01-11 | 1998-03-10 | Novo Nordisk A/S | Benign prostatic hypertrophy |
| IL124882A0 (en) * | 1996-01-11 | 1999-01-26 | Novo Nordisk As | Use of 3, 4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms |
| ATE248157T1 (de) * | 1998-12-30 | 2003-09-15 | Signal Pharm Inc | Verbindungen und verfahren zur modulation von estrogen rezeptoren |
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- 2000-12-29 CN CNB008192227A patent/CN1281598C/zh not_active Expired - Fee Related
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- 2000-12-29 DE DE60018215T patent/DE60018215T2/de not_active Expired - Fee Related
- 2000-12-29 WO PCT/US2000/035671 patent/WO2001049673A2/en not_active Ceased
- 2000-12-29 EP EP00990966A patent/EP1246814B1/en not_active Expired - Lifetime
- 2000-12-29 PT PT00990966T patent/PT1246814E/pt unknown
- 2000-12-29 AT AT00990966T patent/ATE289300T1/de not_active IP Right Cessation
- 2000-12-29 JP JP2001550213A patent/JP2003519219A/ja active Pending
- 2000-12-29 DK DK00990966T patent/DK1246814T3/da active
- 2000-12-29 KR KR1020027008569A patent/KR20020075388A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60018215D1 (de) | 2005-03-24 |
| CN1437591A (zh) | 2003-08-20 |
| CN1281598C (zh) | 2006-10-25 |
| DK1246814T3 (da) | 2005-05-30 |
| IL150463A0 (en) | 2002-12-01 |
| WO2001049673A2 (en) | 2001-07-12 |
| EP1246814B1 (en) | 2005-02-16 |
| EP1246814A2 (en) | 2002-10-09 |
| AU3077101A (en) | 2001-07-16 |
| AU781282B2 (en) | 2005-05-12 |
| WO2001049673A3 (en) | 2001-12-06 |
| HK1058521A1 (en) | 2004-05-21 |
| ATE289300T1 (de) | 2005-03-15 |
| ES2238034T3 (es) | 2005-08-16 |
| KR20020075388A (ko) | 2002-10-04 |
| CA2396059A1 (en) | 2001-07-12 |
| JP2003519219A (ja) | 2003-06-17 |
| PT1246814E (pt) | 2005-07-29 |
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Owner name: SIGNAL PHARMACEUTICALS LLC, SAN DIEGO, CALIF., US |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |