DE60015084T2 - Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden - Google Patents

Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden Download PDF

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Publication number
DE60015084T2
DE60015084T2 DE60015084T DE60015084T DE60015084T2 DE 60015084 T2 DE60015084 T2 DE 60015084T2 DE 60015084 T DE60015084 T DE 60015084T DE 60015084 T DE60015084 T DE 60015084T DE 60015084 T2 DE60015084 T2 DE 60015084T2
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DE
Germany
Prior art keywords
seq
neisseria
protein
composition
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60015084T
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German (de)
English (en)
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DE60015084D1 (de
Inventor
Guido Grandi
Rino Rappuoli
Marzia M. Giuliani
Mariagrazia Pizza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
CHIRON Srl SIENA
Chiron SRL
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Publication of DE60015084T2 publication Critical patent/DE60015084T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60015084T 1999-02-26 2000-02-09 Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden Expired - Lifetime DE60015084T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12179299P 1999-02-26 1999-02-26
US121792P 1999-02-26
PCT/IB2000/000176 WO2000050075A2 (en) 1999-02-26 2000-02-09 Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs

Publications (2)

Publication Number Publication Date
DE60015084D1 DE60015084D1 (de) 2004-11-25
DE60015084T2 true DE60015084T2 (de) 2006-02-16

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DE60015084T Expired - Lifetime DE60015084T2 (de) 1999-02-26 2000-02-09 Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden

Country Status (11)

Country Link
US (1) US8221761B1 (https=)
EP (1) EP1154790B1 (https=)
JP (2) JP4812942B2 (https=)
AT (1) ATE279943T1 (https=)
AU (1) AU2457100A (https=)
CA (1) CA2371994C (https=)
DE (1) DE60015084T2 (https=)
ES (1) ES2228454T3 (https=)
HK (1) HK1042425B (https=)
PT (1) PT1154790E (https=)
WO (1) WO2000050075A2 (https=)

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Also Published As

Publication number Publication date
WO2000050075A3 (en) 2001-01-11
JP2010174044A (ja) 2010-08-12
HK1042425B (en) 2005-04-01
AU2457100A (en) 2000-09-14
CA2371994C (en) 2010-09-28
CA2371994A1 (en) 2000-08-31
US8221761B1 (en) 2012-07-17
PT1154790E (pt) 2005-03-31
EP1154790A2 (en) 2001-11-21
JP4812942B2 (ja) 2011-11-09
JP2002537353A (ja) 2002-11-05
WO2000050075A2 (en) 2000-08-31
ES2228454T3 (es) 2005-04-16
EP1154790B1 (en) 2004-10-20
DE60015084D1 (de) 2004-11-25
ATE279943T1 (de) 2004-11-15
HK1042425A1 (en) 2002-08-16

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Owner name: NOVARTIS VACCINES AND DIAGNOSTICS S.R.L., SIEN, IT