DE60013630T2 - Arzneimittel zur behandlung von darmverstopfung und reizkolon - Google Patents
Arzneimittel zur behandlung von darmverstopfung und reizkolon Download PDFInfo
- Publication number
- DE60013630T2 DE60013630T2 DE60013630T DE60013630T DE60013630T2 DE 60013630 T2 DE60013630 T2 DE 60013630T2 DE 60013630 T DE60013630 T DE 60013630T DE 60013630 T DE60013630 T DE 60013630T DE 60013630 T2 DE60013630 T2 DE 60013630T2
- Authority
- DE
- Germany
- Prior art keywords
- medicament
- antagonist
- release
- opioid antagonist
- opioid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9925872 | 1999-11-01 | ||
| GB9925872A GB9925872D0 (en) | 1999-11-01 | 1999-11-01 | Composition for relief of constipation |
| GB9928314 | 1999-11-30 | ||
| GB9928314A GB9928314D0 (en) | 1999-11-30 | 1999-11-30 | Composition for the treatment of irritable bowel syndrome |
| PCT/GB2000/004167 WO2001032180A2 (en) | 1999-11-01 | 2000-10-30 | Composition for treatment of constipation and irritable bowel syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60013630D1 DE60013630D1 (de) | 2004-10-14 |
| DE60013630T2 true DE60013630T2 (de) | 2005-09-15 |
Family
ID=26316047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60013630T Expired - Lifetime DE60013630T2 (de) | 1999-11-01 | 2000-10-30 | Arzneimittel zur behandlung von darmverstopfung und reizkolon |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6734188B1 (enExample) |
| EP (1) | EP1225897B1 (enExample) |
| JP (1) | JP2003513045A (enExample) |
| AT (1) | ATE275402T1 (enExample) |
| AU (1) | AU776567B2 (enExample) |
| CA (1) | CA2389650C (enExample) |
| CZ (1) | CZ299726B6 (enExample) |
| DE (1) | DE60013630T2 (enExample) |
| DK (1) | DK1225897T3 (enExample) |
| ES (1) | ES2226933T3 (enExample) |
| IL (2) | IL149378A0 (enExample) |
| PT (1) | PT1225897E (enExample) |
| WO (1) | WO2001032180A2 (enExample) |
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| DK1685839T3 (da) | 1997-12-22 | 2013-06-24 | Euro Celtique Sa | Farmaceutisk oral doseringsform omfattende en kombination af en opioidagonist og opioidantagonist |
| PT1225897E (pt) | 1999-11-01 | 2005-01-31 | John Rhodes | Composicao para o tratamento da obstipacao e do sindroma do intestino irritavel |
| AU776666B2 (en) | 2000-02-08 | 2004-09-16 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
| CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
| US7943173B2 (en) | 2001-07-18 | 2011-05-17 | Purdue Pharma L.P. | Pharmaceutical combinations of oxycodone and naloxone |
| US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| WO2003013525A1 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Opioid agonist formulations with releasable and sequestered antagonist |
| CA2478515C (en) * | 2002-04-05 | 2010-09-28 | Purdue Pharma | Pharmaceutical preparation containing oxycodone and naloxone |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| DK1551372T3 (en) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES |
| ATE477268T1 (de) | 2003-01-28 | 2010-08-15 | Ironwood Pharmaceuticals Inc | Zusammensetzungen zur behandlung von magen-darm- störungen |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
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| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
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| JP5797655B2 (ja) * | 2009-09-18 | 2015-10-21 | アドラー・コーポレーション | 消化管障害のためのオピオイド受容体アンタゴニストの使用 |
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| WO2011141490A1 (en) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
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| KR20150046310A (ko) * | 2012-08-29 | 2015-04-29 | 샐릭스 파마슈티컬스 인코포레이티드 | 완화제 조성물 및 변비 및 관련 위장관 질병 및 증상 치료를 위한 방법 |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| SMT201900386T1 (it) | 2013-04-12 | 2019-09-09 | Ardelyx Inc | Composti nhe3-leganti e metodi per l'inibizione del trasporto di fosfato |
| KR20180037074A (ko) | 2013-07-23 | 2018-04-10 | 유로-셀티큐 에스.에이. | 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물 |
| EP3068397A1 (en) | 2013-11-13 | 2016-09-21 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
| EP3229785A2 (de) * | 2014-12-08 | 2017-10-18 | Develco Pharma Schweiz AG | Naloxon-monopräparat und mehrschichttablette |
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| WO2016193456A2 (en) * | 2015-06-03 | 2016-12-08 | Develco Pharma Schweiz Ag | Opioid receptor antagonist for use in treating patients with severe constipation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987136A (en) | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
| DE3381877D1 (de) | 1982-03-16 | 1990-10-18 | Univ Rockefeller | Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler stoerungen. |
| IT1188550B (it) * | 1986-02-07 | 1988-01-14 | Sclavo Spa | Peptide sintetico ad attivita' interleukina 1 umana |
| US4774230A (en) | 1988-03-26 | 1988-09-27 | Ivax Laboratories, Inc. | Glucuronic acid derivatives of opioid antagonists |
| HU218673B (hu) | 1993-10-07 | 2000-10-28 | Euroceltique S.A. | Opioid analgetikumot tartalmazó elnyújtott hatóanyag-felszabadítású orális gyógyszerkészítmény és eljárás előállítására |
| US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| IT1298575B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
| WO2000003660A1 (en) | 1998-07-17 | 2000-01-27 | Skyepharma, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| PT1225897E (pt) | 1999-11-01 | 2005-01-31 | John Rhodes | Composicao para o tratamento da obstipacao e do sindroma do intestino irritavel |
-
2000
- 2000-10-30 PT PT00971617T patent/PT1225897E/pt unknown
- 2000-10-30 US US10/111,850 patent/US6734188B1/en not_active Expired - Fee Related
- 2000-10-30 AT AT00971617T patent/ATE275402T1/de active
- 2000-10-30 JP JP2001534385A patent/JP2003513045A/ja active Pending
- 2000-10-30 ES ES00971617T patent/ES2226933T3/es not_active Expired - Lifetime
- 2000-10-30 IL IL14937800A patent/IL149378A0/xx active IP Right Grant
- 2000-10-30 DE DE60013630T patent/DE60013630T2/de not_active Expired - Lifetime
- 2000-10-30 AU AU10447/01A patent/AU776567B2/en not_active Ceased
- 2000-10-30 CA CA002389650A patent/CA2389650C/en not_active Expired - Fee Related
- 2000-10-30 WO PCT/GB2000/004167 patent/WO2001032180A2/en not_active Ceased
- 2000-10-30 CZ CZ20021536A patent/CZ299726B6/cs not_active IP Right Cessation
- 2000-10-30 DK DK00971617T patent/DK1225897T3/da active
- 2000-10-30 EP EP00971617A patent/EP1225897B1/en not_active Expired - Lifetime
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2002
- 2002-04-28 IL IL149378A patent/IL149378A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1225897T3 (da) | 2005-01-10 |
| WO2001032180A3 (en) | 2001-09-20 |
| US6734188B1 (en) | 2004-05-11 |
| JP2003513045A (ja) | 2003-04-08 |
| PT1225897E (pt) | 2005-01-31 |
| HK1048595A1 (en) | 2003-04-11 |
| DE60013630D1 (de) | 2004-10-14 |
| IL149378A0 (en) | 2002-11-10 |
| EP1225897B1 (en) | 2004-09-08 |
| IL149378A (en) | 2006-12-31 |
| CZ299726B6 (cs) | 2008-11-05 |
| ATE275402T1 (de) | 2004-09-15 |
| AU776567B2 (en) | 2004-09-16 |
| WO2001032180A2 (en) | 2001-05-10 |
| AU1044701A (en) | 2001-05-14 |
| ES2226933T3 (es) | 2005-04-01 |
| CA2389650A1 (en) | 2001-05-10 |
| EP1225897A2 (en) | 2002-07-31 |
| CZ20021536A3 (cs) | 2003-02-12 |
| CA2389650C (en) | 2008-12-09 |
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