DE60013630D1 - Arzneimittel zur behandlung von darmverstopfung und reizkolon - Google Patents
Arzneimittel zur behandlung von darmverstopfung und reizkolonInfo
- Publication number
- DE60013630D1 DE60013630D1 DE60013630T DE60013630T DE60013630D1 DE 60013630 D1 DE60013630 D1 DE 60013630D1 DE 60013630 T DE60013630 T DE 60013630T DE 60013630 T DE60013630 T DE 60013630T DE 60013630 D1 DE60013630 D1 DE 60013630D1
- Authority
- DE
- Germany
- Prior art keywords
- colon
- irritary
- construction
- treatment
- medicinal products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9925872A GB9925872D0 (en) | 1999-11-01 | 1999-11-01 | Composition for relief of constipation |
GB9925872 | 1999-11-01 | ||
GB9928314A GB9928314D0 (en) | 1999-11-30 | 1999-11-30 | Composition for the treatment of irritable bowel syndrome |
GB9928314 | 1999-11-30 | ||
PCT/GB2000/004167 WO2001032180A2 (en) | 1999-11-01 | 2000-10-30 | Composition for treatment of constipation and irritable bowel syndrome |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60013630D1 true DE60013630D1 (de) | 2004-10-14 |
DE60013630T2 DE60013630T2 (de) | 2005-09-15 |
Family
ID=26316047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60013630T Expired - Lifetime DE60013630T2 (de) | 1999-11-01 | 2000-10-30 | Arzneimittel zur behandlung von darmverstopfung und reizkolon |
Country Status (14)
Country | Link |
---|---|
US (1) | US6734188B1 (de) |
EP (1) | EP1225897B1 (de) |
JP (1) | JP2003513045A (de) |
AT (1) | ATE275402T1 (de) |
AU (1) | AU776567B2 (de) |
CA (1) | CA2389650C (de) |
CZ (1) | CZ299726B6 (de) |
DE (1) | DE60013630T2 (de) |
DK (1) | DK1225897T3 (de) |
ES (1) | ES2226933T3 (de) |
HK (1) | HK1048595A1 (de) |
IL (2) | IL149378A0 (de) |
PT (1) | PT1225897E (de) |
WO (1) | WO2001032180A2 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2241458C2 (ru) | 1997-12-22 | 2004-12-10 | Эро-Селтик, С.А. | Комбинации агонист/антагонист опиоида |
AU776567B2 (en) | 1999-11-01 | 2004-09-16 | Evans, Brian K | Composition for treatment of constipation and irritable bowel syndrome |
SI2517710T1 (sl) | 2000-02-08 | 2015-07-31 | Euro-Celtique S.A. | Oralne formulacije opioidnih agonistov, varne pred zlorabo |
JP4522652B2 (ja) | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ, インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
AU2002316738B2 (en) | 2001-07-18 | 2009-01-08 | Euro-Celtique S.A. | Pharmaceutical combinations of oxycodone and naloxone |
US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
MXPA04001210A (es) | 2001-08-06 | 2004-07-08 | Euro Celtique Sa | Formulaciones de agonista opioide con antagonista liberable y aislado. |
JP4620355B2 (ja) | 2002-04-05 | 2011-01-26 | ユーロ−セルティーク エス.エイ. | 活性化合物の持続、不変及び独立放出のためのマトリクス |
US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
CN1703200B (zh) | 2002-09-20 | 2012-02-29 | 奥尔制药公司 | 隔离亚单元和相关组合物及方法 |
BR122018074353B8 (pt) | 2003-01-28 | 2021-07-27 | Ironwood Pharmaceuticals Inc | composição farmacêutica, polipeptídeo e métodos para a produção dos mesmos |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
DK2368553T3 (en) | 2003-04-08 | 2015-02-09 | Progenics Pharm Inc | Pharmaceutical preparation comprising methylnaltrexone |
MXPA05010819A (es) * | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable. |
MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
JP5032300B2 (ja) * | 2004-03-22 | 2012-09-26 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物 |
CA2594987A1 (en) * | 2004-12-14 | 2006-06-22 | Shionogi & Co., Ltd. | Therapeutic agent for constipation |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US9662390B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
RU2413532C2 (ru) | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Способ получения стерилизованного порошкообразного панкреатина |
US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
JP2009534384A (ja) * | 2006-04-19 | 2009-09-24 | ジル・ピー・スミス | オピオイドアンタゴニストによる炎症性および潰瘍性腸疾患の治療 |
US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
DK2719378T3 (en) | 2006-06-19 | 2016-10-17 | Alpharma Pharmaceuticals Llc | pharmaceutical compositions |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
AU2006348180A1 (en) * | 2006-09-13 | 2008-03-20 | Warner Chilcott Company, Llc | Methods of treatment for ulcerative colitis |
BRPI0622007A2 (pt) * | 2006-09-13 | 2011-12-20 | Procter & Gamble | uso de aminossalicilato para tratar colite ulcerativa |
ES2493590T3 (es) | 2007-03-29 | 2014-09-12 | Wyeth Llc | Antagonistas de receptores opioides periféricos y usos de los mismos |
WO2008121348A2 (en) | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
CA2682129A1 (en) | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Crystal forms and uses thereof |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CN101772513B (zh) | 2007-06-04 | 2013-11-13 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
EP2214672B1 (de) * | 2007-10-18 | 2012-10-17 | Aiko Biotechnology | Kombinationsanalgetikum mit einem opioid und einem neutralen antagonisten |
US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
CA2713568C (en) | 2008-02-06 | 2016-09-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
EP2278966B1 (de) | 2008-03-21 | 2019-10-09 | The University of Chicago | Behandlung mit opioid-antagonisten und mtor-inhibitoren |
KR20110004425A (ko) * | 2008-05-07 | 2011-01-13 | 넥타르 테라퓨틱스 | 말초적 작용 오피오이드 길항제의 경구 투여 |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
EP3939964A1 (de) | 2008-12-31 | 2022-01-19 | Ardelyx, Inc. | Kombinationen zur inhibierung des nhe-vermittelten antiports bei der behandlung von mit flüssigkeitsretention und salzüberlastung assoziierten erkrankungen und erkrankungen des magen-darm-trakts |
PT2405915T (pt) | 2009-03-10 | 2019-01-29 | Euro Celtique Sa | Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona |
AU2010238925A1 (en) * | 2009-04-22 | 2011-12-15 | Phoeme Gmbh | Particulate pharmaceutical composition having an opioid and an opioid antagonist |
MX342548B (es) * | 2009-09-18 | 2016-10-04 | Merck Sharp & Dohme Corp * | Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal. |
JP5838199B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス.エイ. | 活性剤を含まない顆粒およびその顆粒を含む錠剤の製造 |
NZ603170A (en) | 2010-05-10 | 2015-04-24 | Euro Celtique Sa | Combination of active loaded granules with additional actives |
AU2013304812B2 (en) | 2012-08-21 | 2016-06-09 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
AU2013308403B2 (en) * | 2012-08-29 | 2019-02-07 | Salix Pharmaceuticals, Inc. | Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
JP6377132B2 (ja) | 2013-04-12 | 2018-08-22 | アーデリクス,インコーポレーテッド | Nhe3結合化合物およびリン酸輸送の阻害方法 |
AU2014295042B2 (en) | 2013-07-23 | 2017-03-30 | Mundipharma Pty Limited | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
MX2016006279A (es) | 2013-11-13 | 2016-09-07 | Euro Celtique Sa | Hidromorfona y naloxona para el tratamiento del dolor y el sindrome de disfuncion intestinal opiacea. |
WO2016091805A2 (de) * | 2014-12-08 | 2016-06-16 | Develco Pharma Schweiz Ag | Naloxon-monopräparat und mehrschichttablette |
US20160256451A1 (en) * | 2015-03-06 | 2016-09-08 | Develco Pharma Schweiz Ag | Dosage of naloxone |
WO2016193456A2 (en) * | 2015-06-03 | 2016-12-08 | Develco Pharma Schweiz Ag | Opioid receptor antagonist for use in treating patients with severe constipation |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
MA47207A (fr) | 2017-01-09 | 2019-11-13 | Ardelyx Inc | Composés utiles pour le traitement de troubles du tractus digestif |
JP2020505333A (ja) | 2017-01-09 | 2020-02-20 | アルデリックス, インコーポレイテッド | Nhe媒介性アンチポートの阻害薬 |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
WO2023102491A1 (en) * | 2021-12-01 | 2023-06-08 | Invea Therapeutics, Inc. | Methods for treating gastrointestinal inflammatory disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3381877D1 (de) | 1982-03-16 | 1990-10-18 | Univ Rockefeller | Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler stoerungen. |
US4987136A (en) | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
IT1188550B (it) * | 1986-02-07 | 1988-01-14 | Sclavo Spa | Peptide sintetico ad attivita' interleukina 1 umana |
US4774230A (en) | 1988-03-26 | 1988-09-27 | Ivax Laboratories, Inc. | Glucuronic acid derivatives of opioid antagonists |
EP0647448A1 (de) | 1993-10-07 | 1995-04-12 | Euroceltique S.A. | Oral verabreichbare, Opioid-Analgetika enthaltende Arzneimittel mit verlängerter Wirkung |
US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
IT1298575B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
CA2338031C (en) | 1998-07-17 | 2006-12-05 | Sankaram Bhima Mantripragada | Biodegradable compositions for the controlled release of encapsulated substances |
AU776567B2 (en) | 1999-11-01 | 2004-09-16 | Evans, Brian K | Composition for treatment of constipation and irritable bowel syndrome |
-
2000
- 2000-10-30 AU AU10447/01A patent/AU776567B2/en not_active Ceased
- 2000-10-30 CZ CZ20021536A patent/CZ299726B6/cs not_active IP Right Cessation
- 2000-10-30 ES ES00971617T patent/ES2226933T3/es not_active Expired - Lifetime
- 2000-10-30 PT PT00971617T patent/PT1225897E/pt unknown
- 2000-10-30 DK DK00971617T patent/DK1225897T3/da active
- 2000-10-30 JP JP2001534385A patent/JP2003513045A/ja active Pending
- 2000-10-30 DE DE60013630T patent/DE60013630T2/de not_active Expired - Lifetime
- 2000-10-30 IL IL14937800A patent/IL149378A0/xx active IP Right Grant
- 2000-10-30 CA CA002389650A patent/CA2389650C/en not_active Expired - Fee Related
- 2000-10-30 US US10/111,850 patent/US6734188B1/en not_active Expired - Fee Related
- 2000-10-30 AT AT00971617T patent/ATE275402T1/de active
- 2000-10-30 WO PCT/GB2000/004167 patent/WO2001032180A2/en active Search and Examination
- 2000-10-30 EP EP00971617A patent/EP1225897B1/de not_active Expired - Lifetime
-
2002
- 2002-04-28 IL IL149378A patent/IL149378A/en not_active IP Right Cessation
-
2003
- 2003-02-04 HK HK03100799A patent/HK1048595A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1044701A (en) | 2001-05-14 |
IL149378A0 (en) | 2002-11-10 |
EP1225897A2 (de) | 2002-07-31 |
CA2389650A1 (en) | 2001-05-10 |
WO2001032180A2 (en) | 2001-05-10 |
JP2003513045A (ja) | 2003-04-08 |
ATE275402T1 (de) | 2004-09-15 |
WO2001032180A3 (en) | 2001-09-20 |
IL149378A (en) | 2006-12-31 |
US6734188B1 (en) | 2004-05-11 |
CA2389650C (en) | 2008-12-09 |
DE60013630T2 (de) | 2005-09-15 |
EP1225897B1 (de) | 2004-09-08 |
PT1225897E (pt) | 2005-01-31 |
CZ20021536A3 (cs) | 2003-02-12 |
CZ299726B6 (cs) | 2008-11-05 |
ES2226933T3 (es) | 2005-04-01 |
AU776567B2 (en) | 2004-09-16 |
DK1225897T3 (da) | 2005-01-10 |
HK1048595A1 (en) | 2003-04-11 |
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