DE60010280T2 - Substituierte pyridazinen und kondensierte pyridazinen mit angiogenesis-inhibierender wirkung - Google Patents
Substituierte pyridazinen und kondensierte pyridazinen mit angiogenesis-inhibierender wirkung Download PDFInfo
- Publication number
- DE60010280T2 DE60010280T2 DE60010280T DE60010280T DE60010280T2 DE 60010280 T2 DE60010280 T2 DE 60010280T2 DE 60010280 T DE60010280 T DE 60010280T DE 60010280 T DE60010280 T DE 60010280T DE 60010280 T2 DE60010280 T2 DE 60010280T2
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- optionally substituted
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- alkyl
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- 230000000694 effects Effects 0.000 title description 3
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 38
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 35
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 21
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims description 20
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 20
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 20
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Classifications
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37132299A | 1999-08-10 | 1999-08-10 | |
| US371322 | 1999-08-10 | ||
| PCT/US2000/021579 WO2001010859A1 (en) | 1999-08-10 | 2000-08-08 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60010280D1 DE60010280D1 (de) | 2004-06-03 |
| DE60010280T2 true DE60010280T2 (de) | 2009-10-15 |
Family
ID=23463486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60010280T Expired - Lifetime DE60010280T2 (de) | 1999-08-10 | 2000-08-08 | Substituierte pyridazinen und kondensierte pyridazinen mit angiogenesis-inhibierender wirkung |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1208096B1 (https=) |
| JP (1) | JP2003506447A (https=) |
| KR (1) | KR20020019969A (https=) |
| CN (1) | CN1378543A (https=) |
| AR (1) | AR025068A1 (https=) |
| AT (1) | ATE265448T1 (https=) |
| AU (1) | AU775237B2 (https=) |
| BR (1) | BR0013113A (https=) |
| CA (1) | CA2381621A1 (https=) |
| CO (1) | CO5180637A1 (https=) |
| DE (1) | DE60010280T2 (https=) |
| ES (1) | ES2219382T3 (https=) |
| IL (1) | IL147885A0 (https=) |
| MX (1) | MXPA02001324A (https=) |
| NO (1) | NO20020569L (https=) |
| NZ (1) | NZ517087A (https=) |
| PE (1) | PE20010494A1 (https=) |
| WO (1) | WO2001010859A1 (https=) |
| ZA (1) | ZA200200691B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GT200000158A (es) * | 1999-09-28 | 2002-03-16 | Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. | |
| US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GB0111078D0 (en) * | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| EP1712234B1 (en) * | 2001-09-12 | 2009-01-28 | Novartis AG | Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment |
| MXPA04005561A (es) * | 2001-12-21 | 2004-12-06 | Bayer Pharmaceuticals Corp | Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina. |
| US7015227B2 (en) | 2002-06-21 | 2006-03-21 | Cgi Pharmaceuticals, Inc. | Certain amino-substituted monocycles as kinase modulators |
| HRP20050281A2 (en) * | 2002-09-24 | 2006-07-31 | Novartis Ag | Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes |
| US20060058313A1 (en) * | 2002-11-12 | 2006-03-16 | Hohneker John A | Treatment of mesothelioma |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| US7776857B2 (en) | 2007-04-05 | 2010-08-17 | Amgen Inc. | Aurora kinase modulators and method of use |
| EP2167549B1 (en) | 2007-06-19 | 2012-09-26 | Rynel, Inc. | Materials comprising water-soluble polymer particles and methods of making and using them |
| ES2413806T3 (es) | 2008-03-20 | 2013-07-17 | Amgen Inc. | Moduladores de la aurora cinasa y método de uso |
| AU2009279760B2 (en) * | 2008-08-04 | 2012-07-12 | Amgen Inc. | Aurora kinase modulators and methods of use |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| CA3206794A1 (en) * | 2021-01-28 | 2022-08-04 | Thomas D. Bannister | Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| JPH0673022A (ja) * | 1992-08-27 | 1994-03-15 | Kumiai Chem Ind Co Ltd | ピリミジンまたはトリアジン誘導体及び除草剤 |
| WO1996005176A1 (en) * | 1994-08-09 | 1996-02-22 | Eisai Co., Ltd. | Fused pyridazine compound |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| WO2000059509A1 (en) * | 1999-03-30 | 2000-10-12 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
-
2000
- 2000-08-07 AR ARP000104073A patent/AR025068A1/es unknown
- 2000-08-08 DE DE60010280T patent/DE60010280T2/de not_active Expired - Lifetime
- 2000-08-08 MX MXPA02001324A patent/MXPA02001324A/es active IP Right Grant
- 2000-08-08 AU AU68954/00A patent/AU775237B2/en not_active Ceased
- 2000-08-08 NZ NZ517087A patent/NZ517087A/en unknown
- 2000-08-08 JP JP2001515668A patent/JP2003506447A/ja active Pending
- 2000-08-08 KR KR1020027001797A patent/KR20020019969A/ko not_active Ceased
- 2000-08-08 CA CA002381621A patent/CA2381621A1/en not_active Abandoned
- 2000-08-08 WO PCT/US2000/021579 patent/WO2001010859A1/en not_active Ceased
- 2000-08-08 CN CN00814059A patent/CN1378543A/zh active Pending
- 2000-08-08 EP EP00957317A patent/EP1208096B1/en not_active Expired - Lifetime
- 2000-08-08 AT AT00957317T patent/ATE265448T1/de not_active IP Right Cessation
- 2000-08-08 IL IL14788500A patent/IL147885A0/xx unknown
- 2000-08-08 BR BR0013113-0A patent/BR0013113A/pt not_active IP Right Cessation
- 2000-08-08 PE PE2000000799A patent/PE20010494A1/es not_active Application Discontinuation
- 2000-08-08 CO CO00059237A patent/CO5180637A1/es unknown
- 2000-08-08 ES ES00957317T patent/ES2219382T3/es not_active Expired - Lifetime
-
2002
- 2002-01-25 ZA ZA200200691A patent/ZA200200691B/en unknown
- 2002-02-05 NO NO20020569A patent/NO20020569L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1208096B1 (en) | 2004-04-28 |
| BR0013113A (pt) | 2002-04-30 |
| NO20020569D0 (no) | 2002-02-05 |
| AR025068A1 (es) | 2002-11-06 |
| MXPA02001324A (es) | 2002-07-22 |
| KR20020019969A (ko) | 2002-03-13 |
| NO20020569L (no) | 2002-04-10 |
| EP1208096A1 (en) | 2002-05-29 |
| PE20010494A1 (es) | 2001-06-27 |
| AU6895400A (en) | 2001-03-05 |
| ES2219382T3 (es) | 2004-12-01 |
| DE60010280D1 (de) | 2004-06-03 |
| AU775237B2 (en) | 2004-07-22 |
| CA2381621A1 (en) | 2001-02-15 |
| NZ517087A (en) | 2004-05-28 |
| WO2001010859A1 (en) | 2001-02-15 |
| ZA200200691B (en) | 2003-10-29 |
| CO5180637A1 (es) | 2002-07-30 |
| JP2003506447A (ja) | 2003-02-18 |
| CN1378543A (zh) | 2002-11-06 |
| ATE265448T1 (de) | 2004-05-15 |
| IL147885A0 (en) | 2002-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |