DE60005257D1 - Verfahren für die Racemisation der atropisomerischen Bis (phosphinoxid) Verbindungen - Google Patents

Verfahren für die Racemisation der atropisomerischen Bis (phosphinoxid) Verbindungen

Info

Publication number
DE60005257D1
DE60005257D1 DE60005257T DE60005257T DE60005257D1 DE 60005257 D1 DE60005257 D1 DE 60005257D1 DE 60005257 T DE60005257 T DE 60005257T DE 60005257 T DE60005257 T DE 60005257T DE 60005257 D1 DE60005257 D1 DE 60005257D1
Authority
DE
Germany
Prior art keywords
racemization
heating
compounds
phosphine oxide
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005257T
Other languages
English (en)
Other versions
DE60005257T2 (de
Inventor
Frank Kienzle
Michel Lalonde
Rudolf Schmid
Shaoning Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60005257D1 publication Critical patent/DE60005257D1/de
Publication of DE60005257T2 publication Critical patent/DE60005257T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5329—Polyphosphine oxides or thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/505—Preparation; Separation; Purification; Stabilisation
    • C07F9/5054—Preparation; Separation; Purification; Stabilisation by a process in which the phosphorus atom is not involved

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60005257T 1999-07-09 2000-07-03 Verfahren für die Racemisation der atropisomerischen Bis (phosphinoxid) Verbindungen Expired - Lifetime DE60005257T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99113306 1999-07-09
EP99113306 1999-07-09

Publications (2)

Publication Number Publication Date
DE60005257D1 true DE60005257D1 (de) 2003-10-23
DE60005257T2 DE60005257T2 (de) 2004-07-01

Family

ID=8238553

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60005257T Expired - Lifetime DE60005257T2 (de) 1999-07-09 2000-07-03 Verfahren für die Racemisation der atropisomerischen Bis (phosphinoxid) Verbindungen

Country Status (13)

Country Link
US (1) US6288280B1 (de)
EP (1) EP1067133B1 (de)
JP (1) JP3688563B2 (de)
KR (1) KR100385800B1 (de)
CN (1) CN1163499C (de)
AT (1) ATE250072T1 (de)
BR (2) BRPI0002650B8 (de)
CA (1) CA2313338C (de)
DE (1) DE60005257T2 (de)
DK (1) DK1067133T3 (de)
ES (1) ES2204411T3 (de)
JO (1) JO2284B1 (de)
MX (1) MXPA00006740A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031110A2 (de) * 2002-10-01 2004-04-15 Dieter Arlt Isomerisierung von chiral einheitlichen o,o'-dihydroxy-biphenylderivaten
JP4375997B2 (ja) * 2003-05-19 2009-12-02 三洋電機株式会社 有機化合物の製造方法及び製造装置
EP1636243B1 (de) * 2003-06-13 2013-11-06 Boehringer Ingelheim International GmbH Chirale liganden zur anwendung in asymmetrischen synthesen
CN100497297C (zh) * 2005-01-24 2009-06-10 南京大学 光学活性氨基酸或其盐的微波消旋方法
CN108303385B (zh) * 2017-10-21 2021-12-24 聊城鲁西多元醇新材料科技有限公司 一种测定双膦配体铑催化剂中铑含量的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274125A (en) 1991-03-15 1993-12-28 Hoffmann-La Roche Inc. Chirale phosphines
US5334766A (en) * 1991-04-29 1994-08-02 Hoffmann-La Roche Inc. Process for the resolution of racemic diphosphine oxides
EP0579797B1 (de) 1992-01-31 1999-04-21 F. Hoffmann-La Roche Ag Diphosphinliganden
WO1996009290A1 (en) * 1994-09-23 1996-03-28 Chiroscience Limited Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
JP3148136B2 (ja) * 1996-12-26 2001-03-19 高砂香料工業株式会社 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒
US6162929A (en) * 1997-12-23 2000-12-19 Hoffmann-La Roche Inc. Process for the manufacture of bisphosphine oxide and bisphosphonate compounds

Also Published As

Publication number Publication date
MXPA00006740A (es) 2005-04-14
EP1067133A1 (de) 2001-01-10
JP2001039993A (ja) 2001-02-13
US6288280B1 (en) 2001-09-11
CN1281860A (zh) 2001-01-31
EP1067133B1 (de) 2003-09-17
CA2313338A1 (en) 2001-01-09
JO2284B1 (en) 2005-09-12
ES2204411T3 (es) 2004-05-01
KR100385800B1 (ko) 2003-06-02
KR20010049732A (ko) 2001-06-15
BR0002650A (pt) 2001-03-13
DK1067133T3 (da) 2004-01-19
JP3688563B2 (ja) 2005-08-31
CN1163499C (zh) 2004-08-25
ATE250072T1 (de) 2003-10-15
BRPI0002650B8 (pt) 2019-02-26
DE60005257T2 (de) 2004-07-01
BR0002650B1 (pt) 2011-12-27
CA2313338C (en) 2008-12-30

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