BRPI0002650B8 - processo para a racemização de compostos atropisoméricos,seu uso e processo para a fabricação de complexos de metal de transição opticamente ativos. - Google Patents
processo para a racemização de compostos atropisoméricos,seu uso e processo para a fabricação de complexos de metal de transição opticamente ativos.Info
- Publication number
- BRPI0002650B8 BRPI0002650B8 BRPI0002650A BRPI0002650A BRPI0002650B8 BR PI0002650 B8 BRPI0002650 B8 BR PI0002650B8 BR PI0002650 A BRPI0002650 A BR PI0002650A BR PI0002650 A BRPI0002650 A BR PI0002650A BR PI0002650 B8 BRPI0002650 B8 BR PI0002650B8
- Authority
- BR
- Brazil
- Prior art keywords
- racemization
- heating
- transition metal
- optically active
- metal complexes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000006340 racemization Effects 0.000 title abstract 3
- 229910052723 transition metal Inorganic materials 0.000 title abstract 2
- 150000003624 transition metals Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000010438 heat treatment Methods 0.000 abstract 3
- 230000003287 optical effect Effects 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5329—Polyphosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/505—Preparation; Separation; Purification; Stabilisation
- C07F9/5054—Preparation; Separation; Purification; Stabilisation by a process in which the phosphorus atom is not involved
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
patente de invenção: <b>"processo para a racemização de compostos de bis(óxido de fosfina) atropisoméricos"<d>. a presente invenção diz respeito a um novo processo para a racemização de compostos de bis (óxido de fosfina) atropisoméricos da fórmula i; em suas formas (r) ou (s) ou não-racêmicas, para a preparação de ligantes óticos ativos de bisfosfina, os quais formam complexos óticos ativos com metais de transição. esses complexos são usados como catalisadores em uma quantidade de reações assimétricas. a racemização é térmica e executada em solvente de alto ou baixo ponto de ebulição, sob pressão normal ou elevada a 10^ 5^ até 3,5 x 10^ 7^ pa. o aquecimento realizado em um sistema que permita o aquecimento até 400°c (reator, autoclave, bloco de alumínio, frasco de fundo redondo com dispositivo de aquecimento agitação e os semelhantes) ou por irradiação de microondas ou em material fundido em uma temperatura a partir de 260 até 400°c, de preferência a partir de 280 até 380°c, em forma de lote ou de uma maneira contínua.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99113306 | 1999-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0002650B8 true BRPI0002650B8 (pt) | 2019-02-26 |
Family
ID=8238553
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0002650A BRPI0002650B8 (pt) | 1999-07-09 | 2000-07-07 | processo para a racemização de compostos atropisoméricos,seu uso e processo para a fabricação de complexos de metal de transição opticamente ativos. |
| BRPI0002650-6A BR0002650B1 (pt) | 1999-07-09 | 2000-07-07 | processo para a racemizaÇço de compostos atropisomÉricos,seu uso e processo para a fabricaÇço de complexos de metal de transiÇço opticamente ativos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0002650-6A BR0002650B1 (pt) | 1999-07-09 | 2000-07-07 | processo para a racemizaÇço de compostos atropisomÉricos,seu uso e processo para a fabricaÇço de complexos de metal de transiÇço opticamente ativos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6288280B1 (pt) |
| EP (1) | EP1067133B1 (pt) |
| JP (1) | JP3688563B2 (pt) |
| KR (1) | KR100385800B1 (pt) |
| CN (1) | CN1163499C (pt) |
| AT (1) | ATE250072T1 (pt) |
| BR (2) | BRPI0002650B8 (pt) |
| CA (1) | CA2313338C (pt) |
| DE (1) | DE60005257T2 (pt) |
| DK (1) | DK1067133T3 (pt) |
| ES (1) | ES2204411T3 (pt) |
| JO (1) | JO2284B1 (pt) |
| MX (1) | MXPA00006740A (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031110A2 (de) * | 2002-10-01 | 2004-04-15 | Dieter Arlt | Isomerisierung von chiral einheitlichen o,o'-dihydroxy-biphenylderivaten |
| JP4375997B2 (ja) * | 2003-05-19 | 2009-12-02 | 三洋電機株式会社 | 有機化合物の製造方法及び製造装置 |
| EP1636243B1 (de) * | 2003-06-13 | 2013-11-06 | Boehringer Ingelheim International GmbH | Chirale liganden zur anwendung in asymmetrischen synthesen |
| CN100497297C (zh) * | 2005-01-24 | 2009-06-10 | 南京大学 | 光学活性氨基酸或其盐的微波消旋方法 |
| CN108303385B (zh) * | 2017-10-21 | 2021-12-24 | 聊城鲁西多元醇新材料科技有限公司 | 一种测定双膦配体铑催化剂中铑含量的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274125A (en) | 1991-03-15 | 1993-12-28 | Hoffmann-La Roche Inc. | Chirale phosphines |
| US5334766A (en) * | 1991-04-29 | 1994-08-02 | Hoffmann-La Roche Inc. | Process for the resolution of racemic diphosphine oxides |
| EP0579797B1 (de) | 1992-01-31 | 1999-04-21 | F. Hoffmann-La Roche Ag | Diphosphinliganden |
| WO1996009290A1 (en) * | 1994-09-23 | 1996-03-28 | Chiroscience Limited | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
| JP3148136B2 (ja) * | 1996-12-26 | 2001-03-19 | 高砂香料工業株式会社 | 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒 |
| US6162929A (en) * | 1997-12-23 | 2000-12-19 | Hoffmann-La Roche Inc. | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
-
2000
- 2000-06-15 US US09/594,643 patent/US6288280B1/en not_active Expired - Lifetime
- 2000-07-03 AT AT00114219T patent/ATE250072T1/de active
- 2000-07-03 DE DE60005257T patent/DE60005257T2/de not_active Expired - Lifetime
- 2000-07-03 DK DK00114219T patent/DK1067133T3/da active
- 2000-07-03 ES ES00114219T patent/ES2204411T3/es not_active Expired - Lifetime
- 2000-07-03 EP EP00114219A patent/EP1067133B1/en not_active Expired - Lifetime
- 2000-07-04 CA CA002313338A patent/CA2313338C/en not_active Expired - Lifetime
- 2000-07-05 JP JP2000203499A patent/JP3688563B2/ja not_active Expired - Lifetime
- 2000-07-06 JO JO2000111A patent/JO2284B1/en active
- 2000-07-07 BR BRPI0002650A patent/BRPI0002650B8/pt unknown
- 2000-07-07 CN CNB001204173A patent/CN1163499C/zh not_active Expired - Lifetime
- 2000-07-07 BR BRPI0002650-6A patent/BR0002650B1/pt not_active IP Right Cessation
- 2000-07-07 MX MXPA00006740A patent/MXPA00006740A/es active IP Right Grant
- 2000-07-07 KR KR10-2000-0038763A patent/KR100385800B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA00006740A (es) | 2005-04-14 |
| EP1067133A1 (en) | 2001-01-10 |
| JP2001039993A (ja) | 2001-02-13 |
| US6288280B1 (en) | 2001-09-11 |
| CN1281860A (zh) | 2001-01-31 |
| EP1067133B1 (en) | 2003-09-17 |
| CA2313338A1 (en) | 2001-01-09 |
| JO2284B1 (en) | 2005-09-12 |
| ES2204411T3 (es) | 2004-05-01 |
| KR100385800B1 (ko) | 2003-06-02 |
| KR20010049732A (ko) | 2001-06-15 |
| BR0002650A (pt) | 2001-03-13 |
| DK1067133T3 (da) | 2004-01-19 |
| JP3688563B2 (ja) | 2005-08-31 |
| CN1163499C (zh) | 2004-08-25 |
| ATE250072T1 (de) | 2003-10-15 |
| DE60005257T2 (de) | 2004-07-01 |
| DE60005257D1 (de) | 2003-10-23 |
| BR0002650B1 (pt) | 2011-12-27 |
| CA2313338C (en) | 2008-12-30 |
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