DE59712460D1 - Messvorrichtung mit einem planaren optischen wellenleiter - Google Patents

Messvorrichtung mit einem planaren optischen wellenleiter

Info

Publication number
DE59712460D1
DE59712460D1 DE59712460T DE59712460T DE59712460D1 DE 59712460 D1 DE59712460 D1 DE 59712460D1 DE 59712460 T DE59712460 T DE 59712460T DE 59712460 T DE59712460 T DE 59712460T DE 59712460 D1 DE59712460 D1 DE 59712460D1
Authority
DE
Germany
Prior art keywords
excitation radiation
wave
optical waveguide
planar optical
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59712460T
Other languages
German (de)
English (en)
Inventor
Gerolf Kraus
Michael Pawlak
Gert Ludwig Duveneck
Peter Oroszlan
Andreas Helg
Alfredo Emilio Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP96810807A external-priority patent/EP0843172A1/de
Priority claimed from EP96810808A external-priority patent/EP0843173A1/de
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE59712460D1 publication Critical patent/DE59712460D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Optical Integrated Circuits (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
DE59712460T 1996-11-18 1997-11-18 Messvorrichtung mit einem planaren optischen wellenleiter Expired - Lifetime DE59712460D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96810807A EP0843172A1 (de) 1996-11-18 1996-11-18 Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
EP96810808A EP0843173A1 (de) 1996-11-18 1996-11-18 Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
PCT/EP1997/006443 WO1998022799A2 (de) 1996-11-18 1997-11-18 Messvorrichtung und deren verwendung

Publications (1)

Publication Number Publication Date
DE59712460D1 true DE59712460D1 (de) 2005-12-01

Family

ID=26144278

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59712460T Expired - Lifetime DE59712460D1 (de) 1996-11-18 1997-11-18 Messvorrichtung mit einem planaren optischen wellenleiter

Country Status (7)

Country Link
US (2) US6198869B1 (enExample)
EP (1) EP0938656B1 (enExample)
JP (1) JP3748571B2 (enExample)
AT (1) ATE308039T1 (enExample)
AU (1) AU6291498A (enExample)
DE (1) DE59712460D1 (enExample)
WO (1) WO1998022799A2 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4662623B2 (ja) * 1998-02-05 2011-03-30 ノバルティス アーゲー ルミネッセンスを測定する方法及び装置
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
WO2000036442A1 (en) * 1998-10-29 2000-06-22 Mark Stephen Braiman Tapered quasi-planar germanium waveguides for mid-ir sensing
DE19856041A1 (de) * 1998-12-04 2000-07-13 Inst Chemo Biosensorik Verfahren und Vorrichtung zur Durchführung von quantitativen Fluoreszenz markierten Affinitätstests
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
HK1046438B (en) 1999-07-05 2007-05-04 Novartis Ag Process of using a sensor platform
AU6834700A (en) 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
ATE299589T1 (de) † 1999-08-20 2005-07-15 Diagnostische Forsch Stiftung Verfahren zur bestimmung von substanzen mittels der evaneszenzfeldmethode
DE19948087B4 (de) * 1999-10-06 2008-04-17 Evotec Ag Verfahren zur Herstellung eines Reaktionssubstrats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6592733B1 (en) 1999-11-12 2003-07-15 Motorola, Inc. Capillary electrophoresis devices incorporating optical waveguides
DE50006533D1 (de) 1999-12-17 2004-06-24 Zeptosens Ag Witterswil Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
US6580507B2 (en) * 2000-03-02 2003-06-17 Sd Acquisition Inc. Single source, single detector chip, multiple-longitudinal channel electromagnetic radiation absorbance and fluorescence monitoring system
EP1281063A1 (de) * 2000-05-06 2003-02-05 Zeptosens AG Gitter-wellenleiter-struktur für multianalytbestimmungen und deren verwendung
AU2001274068A1 (en) 2000-06-02 2001-12-11 Zeptosens Ag Kit and method for determining a plurality of analytes
WO2002001194A1 (en) 2000-06-25 2002-01-03 Affymetrix, Inc. Optically active substrates
DE10058095C2 (de) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Vorrichtung zur Bestimmung von Analyten durch Chemilumineszenz
EP1405056A1 (de) * 2001-06-15 2004-04-07 Zeptosens AG Körper für durchflussküvetten und deren verwendung
GB0207944D0 (en) * 2002-04-05 2002-05-15 Univ Cambridge Tech Method of detection
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
DE10307802A1 (de) * 2003-02-24 2004-09-09 Advalytix Ag Analyseverfahren und -Vorrichtung zur Analyse von spezifischen Bindungsreaktionen
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
DE102004039564B4 (de) * 2004-08-13 2006-06-29 Institut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm Vorrichtung zum optischen Screening von Oberflächen biologischer Proben in zweidimensionaler Anordnung
US7095941B2 (en) * 2004-10-27 2006-08-22 Schott Corporation Fused optical fiber optical device system
JP2006162538A (ja) * 2004-12-10 2006-06-22 Seiko Instruments Inc 微量質量測定装置
GB0501944D0 (en) 2005-01-31 2005-03-09 Univ Cambridge Tech Compounds for use in chemical detection and/or quantitation
JP4290128B2 (ja) * 2005-02-25 2009-07-01 キヤノン株式会社 センサ
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US7639355B2 (en) * 2007-06-26 2009-12-29 Hewlett-Packard Development Company, L.P. Electric-field-enhancement structure and detection apparatus using same
DE102007033124B4 (de) * 2007-07-16 2012-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium
JP2009133836A (ja) * 2007-11-06 2009-06-18 Toshiba Corp 光学式センサ
US7860354B2 (en) * 2007-11-06 2010-12-28 Kabushiki Kaisha Toshiba Optical sensor
EP2110694B1 (en) 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
CA2737505C (en) * 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
JP2010151510A (ja) * 2008-12-24 2010-07-08 Tdk Corp 液性測定装置
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8586347B2 (en) 2010-09-15 2013-11-19 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
CN102460254B (zh) * 2009-04-29 2015-05-06 Plc诊断股份有限公司 具有扫描光源的基于波导的检测系统
JP5272965B2 (ja) * 2009-08-19 2013-08-28 株式会社島津製作所 蛍光検出器
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8467061B2 (en) 2010-02-19 2013-06-18 Pacific Biosciences Of California, Inc. Integrated analytical system and method
WO2012004735A1 (en) * 2010-07-09 2012-01-12 Koninklijke Philips Electronics N.V. Cartridge with large-scale manufacturing design
US8750652B2 (en) * 2010-10-12 2014-06-10 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic waveguide detector
EP2641077B1 (en) * 2010-11-19 2022-03-02 The Regents of The University of California Opto-fluidic apparatus for analyzing samples and detecting of individual particles
RU2014113337A (ru) * 2011-09-06 2015-10-20 Конинклейке Филипс Н.В. Способ и устройство для ввода светового пучка в пленку
WO2013108087A1 (en) * 2012-01-18 2013-07-25 Jawaharlal Nehru Centre For Advanced Scientific Research A system and a method to detect hydrogen leakage using nano-crystallised palladium gratings
CN110452809B (zh) 2013-11-17 2022-07-01 宽腾矽公司 与测定芯片通过接口连接的仪器
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP2916125A1 (en) * 2014-03-07 2015-09-09 One Drop Diagnostics Sàrl Fluorescence-detected assays on microfluidic chips
CN112903639B (zh) 2014-08-08 2022-09-13 宽腾矽公司 用于对分子进行探测、检测和分析的带外部光源的集成装置
AU2015300766B2 (en) 2014-08-08 2021-02-04 Quantum-Si Incorporated Integrated device for temporal binning of received photons
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
BR112017002489B1 (pt) 2014-08-08 2023-02-14 Quantum-Si Incorporated Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
AU2016259012C1 (en) 2015-05-07 2022-11-17 Pacific Biosciences Of California, Inc. Multiprocessor pipeline architecture
EP3317641B1 (en) * 2015-06-30 2019-03-06 IMEC vzw Radiation carrier and use thereof in an optical sensor
TWI734748B (zh) 2016-02-17 2021-08-01 美商太斯萊特健康股份有限公司 用於生命期成像及偵測應用之感測器及裝置
CA3047826A1 (en) 2016-12-22 2018-06-28 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
WO2018160595A2 (en) 2017-02-28 2018-09-07 The Regents Of The University Of California Optofluidic analyte detection systems using multi-mode interference waveguides
WO2019023174A1 (en) 2017-07-24 2019-01-31 Quantum-Si Incorporated MASSIVELY PARALLEL BIO-OPTOELECTRONIC INSTRUMENT HAND-HELD
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
US11994504B2 (en) 2020-09-18 2024-05-28 Salvus, Llc Interferometric detection and quantification system and methods of use in food processing and food supply chain
US11740177B2 (en) 2020-09-18 2023-08-29 Salvus, Llc Interferometric detection and quantification system and methods of use in aquatics
US12399172B2 (en) 2020-09-18 2025-08-26 Salvus, Llc Interferometric detection and quantification system and methods of use in healthcare
US20220091031A1 (en) * 2020-09-18 2022-03-24 Salvus, Llc Interferometric Detection and Quantification System and Methods of Use in Chemical Processing
DE102020133924A1 (de) 2020-12-17 2022-06-23 Carl Zeiss Jena Gmbh Chiplabor-system mit funktionalisiertem wellenleiter

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3481644D1 (de) * 1984-12-10 1990-04-19 Prutec Ltd Verfahren zum optischen nachweis von parametern von substanzen in einem fluessigen analyt.
SE462408B (sv) 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5830766A (en) * 1990-05-23 1998-11-03 Ares-Serono Research & Development Ltd. Partnership Enhanced signal-to-noise ratio and sensitivity optical immunoassay
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
CN1149335A (zh) 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法
MX9708698A (es) 1995-05-12 1998-02-28 Novartis Ag Plataforma de sensor y metodo para la deteccion paralela de una pluralidad de analitos utilizando luminescencia evanescentemente excitada.
WO1997001087A1 (en) * 1995-06-23 1997-01-09 Novartis Ag Flow cell
USRE39772E1 (en) * 1996-03-19 2007-08-14 University Of Utah Research Foundation Lens and associatable flow cell
JP3266041B2 (ja) * 1996-05-22 2002-03-18 株式会社島津製作所 部材接合法及びこの方法により製造した光学測定装置
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays

Also Published As

Publication number Publication date
WO1998022799A2 (de) 1998-05-28
WO1998022799A3 (de) 1998-08-20
JP3748571B2 (ja) 2006-02-22
US20010001021A1 (en) 2001-05-10
US6198869B1 (en) 2001-03-06
ATE308039T1 (de) 2005-11-15
EP0938656A2 (de) 1999-09-01
EP0938656B1 (de) 2005-10-26
JP2001504230A (ja) 2001-03-27
US6384912B2 (en) 2002-05-07
AU6291498A (en) 1998-06-10

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Legal Events

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8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8328 Change in the person/name/address of the agent

Representative=s name: LUETJENS, H., DIPL.-CHEM. DR. RER. NAT., PAT.-ANW.