DE4239877C1 - Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung - Google Patents

Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Info

Publication number
DE4239877C1
DE4239877C1 DE4239877A DE4239877A DE4239877C1 DE 4239877 C1 DE4239877 C1 DE 4239877C1 DE 4239877 A DE4239877 A DE 4239877A DE 4239877 A DE4239877 A DE 4239877A DE 4239877 C1 DE4239877 C1 DE 4239877C1
Authority
DE
Germany
Prior art keywords
cyclodextrin
sod
solution
superoxide dismutase
mannitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE4239877A
Other languages
German (de)
English (en)
Inventor
Reiner Dr Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to DE4239877A priority Critical patent/DE4239877C1/de
Priority to US08/152,015 priority patent/US5464614A/en
Priority to EP19930118801 priority patent/EP0599262A3/de
Priority to TW082109868A priority patent/TW252046B/zh
Priority to KR1019930025154A priority patent/KR940011014A/ko
Priority to IL10775493A priority patent/IL107754A/en
Priority to NZ250285A priority patent/NZ250285A/en
Priority to ZA938848A priority patent/ZA938848B/xx
Priority to PH47341A priority patent/PH30788A/en
Priority to AU51953/93A priority patent/AU671495B2/en
Priority to HU9303365A priority patent/HUT65580A/hu
Priority to FI935264A priority patent/FI935264A7/fi
Priority to NO934289A priority patent/NO934289L/no
Priority to CA002110087A priority patent/CA2110087A1/en
Priority to JP5295795A priority patent/JPH06199691A/ja
Priority to MX9307433A priority patent/MX9307433A/es
Application granted granted Critical
Publication of DE4239877C1 publication Critical patent/DE4239877C1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DE4239877A 1992-11-27 1992-11-27 Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung Expired - Fee Related DE4239877C1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE4239877A DE4239877C1 (de) 1992-11-27 1992-11-27 Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
US08/152,015 US5464614A (en) 1992-11-27 1993-11-15 Stabilized superoxide dismutase (SOD) composition
EP19930118801 EP0599262A3 (de) 1992-11-27 1993-11-23 Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung.
TW082109868A TW252046B (enrdf_load_stackoverflow) 1992-11-27 1993-11-23
KR1019930025154A KR940011014A (ko) 1992-11-27 1993-11-24 안정화된 수퍼옥사이드 디스뮤타아제(sod) 조성물
NZ250285A NZ250285A (en) 1992-11-27 1993-11-25 Pharmaceutical compositions containing superoxide dismutase (sod), cyclodextrin, and sugars or sugar alcohols
IL10775493A IL107754A (en) 1992-11-27 1993-11-25 Stabilised superoxide dismutase (sod) compositions their preparation and pharmaceutical formulations containing them
PH47341A PH30788A (en) 1992-11-27 1993-11-26 Stabilized superoxide dismutase (sod) composition.
ZA938848A ZA938848B (en) 1992-11-27 1993-11-26 Stabilised superoxide dismutase (SOD) composition.
AU51953/93A AU671495B2 (en) 1992-11-27 1993-11-26 Stabilised superoxide dismutase (SOD) composition
HU9303365A HUT65580A (en) 1992-11-27 1993-11-26 Stabilized superoxide-dismutase (sod) composition
FI935264A FI935264A7 (fi) 1992-11-27 1993-11-26 Stabiloidut superoksidi-dismutaasi(SOD)-koostumukset
NO934289A NO934289L (no) 1992-11-27 1993-11-26 Stabilisert superoksyd-dismutase (SOD)-blanding
CA002110087A CA2110087A1 (en) 1992-11-27 1993-11-26 Stabilised superoxide dismutase (sod) composition
JP5295795A JPH06199691A (ja) 1992-11-27 1993-11-26 安定化スーパーオキシドジスムターゼ組成物
MX9307433A MX9307433A (es) 1992-11-27 1993-11-26 Composicion de superoxido-dismutasa estabilizada, procedimiento para su preparacion y composicion farmaceutica que la contiene.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4239877A DE4239877C1 (de) 1992-11-27 1992-11-27 Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Publications (1)

Publication Number Publication Date
DE4239877C1 true DE4239877C1 (de) 1994-03-17

Family

ID=6473780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4239877A Expired - Fee Related DE4239877C1 (de) 1992-11-27 1992-11-27 Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Country Status (16)

Country Link
US (1) US5464614A (enrdf_load_stackoverflow)
EP (1) EP0599262A3 (enrdf_load_stackoverflow)
JP (1) JPH06199691A (enrdf_load_stackoverflow)
KR (1) KR940011014A (enrdf_load_stackoverflow)
AU (1) AU671495B2 (enrdf_load_stackoverflow)
CA (1) CA2110087A1 (enrdf_load_stackoverflow)
DE (1) DE4239877C1 (enrdf_load_stackoverflow)
FI (1) FI935264A7 (enrdf_load_stackoverflow)
HU (1) HUT65580A (enrdf_load_stackoverflow)
IL (1) IL107754A (enrdf_load_stackoverflow)
MX (1) MX9307433A (enrdf_load_stackoverflow)
NO (1) NO934289L (enrdf_load_stackoverflow)
NZ (1) NZ250285A (enrdf_load_stackoverflow)
PH (1) PH30788A (enrdf_load_stackoverflow)
TW (1) TW252046B (enrdf_load_stackoverflow)
ZA (1) ZA938848B (enrdf_load_stackoverflow)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
US5876992A (en) * 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US6132712A (en) * 1996-12-11 2000-10-17 A. Glenn Braswell Superoxide dismutase stabilized with fragments of casein and pharmaceutical compositions incorporating same
US20040132653A1 (en) * 1997-01-30 2004-07-08 Biopharm Gmbh Lyophilized composition of bone morphogenetic factor human MP52
EP0972520B9 (en) * 1997-01-30 2006-03-22 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Freeze-dried composition of bone morphogenetic protein human mp52
US20030022243A1 (en) * 2001-06-20 2003-01-30 Les Kondejewski Protein aggregation assays and uses thereof
DE10223783A1 (de) * 2002-05-29 2003-12-11 Boehringer Ingelheim Pharma Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers
CN100537602C (zh) * 2003-10-31 2009-09-09 金泰润 Ec sod和细胞转导性ec sod及它们的用途
US8318803B2 (en) * 2003-10-31 2012-11-27 Tae-Yoon Kim EC SOD and use thereof
KR101010055B1 (ko) * 2008-06-16 2011-01-21 한국전력공사 디스크 유량계 및 그의 제어방법
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
PT2919801T (pt) * 2012-10-26 2020-07-30 Lupin Atlantis Holdings Sa Composição farmacêutica estável da proteína de fusão tnfr:fc etanercept
EP3091069A1 (en) 2015-05-06 2016-11-09 Fitoplancton Marino S.L. Method for obtaining a biomass of a microalga of the species tetraselmis chuii enriched in superoxide dismutase (sod)

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JPS5712993A (en) * 1980-06-23 1982-01-22 Fujirebio Inc Isolation of superoxide dismutase
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EP0080879B1 (en) * 1981-11-28 1986-10-01 Sunstar Kabushiki Kaisha Pharmaceutical composition containing interferon in stable state
US4447355A (en) * 1982-04-07 1984-05-08 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same
EP0123291A2 (en) * 1983-04-20 1984-10-31 Kyowa Hakko Kogyo Co., Ltd. Method for stabilizing interferon
ATE155527T1 (de) * 1983-10-03 1997-08-15 Chiron Corp Superoxiddismutase und deren expression in mikroorganismen
JPS60155133A (ja) * 1983-11-09 1985-08-15 シンビオテイツクス　コ−ポレイシヨン アンチ−イデイオタイプのモノクロナル抗体を採用したアンチ−イデイオタイプワクチン
JPS60228422A (ja) * 1984-04-26 1985-11-13 Suntory Ltd 安定化された生理活性物質製剤
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CA1232850A (en) * 1985-01-17 1988-02-16 Albert D. Friesen Purification of superoxide dismutase
ES8800982A1 (es) * 1985-07-05 1987-12-01 Takeda Chemical Industries Ltd Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina.
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Also Published As

Publication number Publication date
HUT65580A (en) 1994-07-28
MX9307433A (es) 1994-08-31
HU9303365D0 (en) 1994-03-28
FI935264L (fi) 1994-05-28
FI935264A7 (fi) 1994-05-28
NO934289D0 (no) 1993-11-26
AU5195393A (en) 1994-06-09
PH30788A (en) 1997-10-17
NO934289L (no) 1994-05-30
EP0599262A3 (de) 1994-11-23
AU671495B2 (en) 1996-08-29
ZA938848B (en) 1995-04-06
JPH06199691A (ja) 1994-07-19
IL107754A0 (en) 1994-02-27
FI935264A0 (fi) 1993-11-26
TW252046B (enrdf_load_stackoverflow) 1995-07-21
NZ250285A (en) 1995-04-27
EP0599262A2 (de) 1994-06-01
US5464614A (en) 1995-11-07
KR940011014A (ko) 1994-06-20
IL107754A (en) 1996-10-16
CA2110087A1 (en) 1994-05-28

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8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIO-TECHNOLOGY GENERAL CORP., ISELIN, N.J., US

8339 Ceased/non-payment of the annual fee