DE4226279A1 - Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel - Google Patents

Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Info

Publication number
DE4226279A1
DE4226279A1 DE4226279A DE4226279A DE4226279A1 DE 4226279 A1 DE4226279 A1 DE 4226279A1 DE 4226279 A DE4226279 A DE 4226279A DE 4226279 A DE4226279 A DE 4226279A DE 4226279 A1 DE4226279 A1 DE 4226279A1
Authority
DE
Germany
Prior art keywords
formula
substituted
mercapto
liponucleotides
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4226279A
Other languages
German (de)
English (en)
Inventor
Dieter Dr Hermann
Harald Dipl Chem Dr Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE4226279A priority Critical patent/DE4226279A1/de
Priority to TW082105422A priority patent/TW306924B/zh
Priority to MX9304676A priority patent/MX9304676A/es
Priority to IL106588A priority patent/IL106588A/en
Priority to DK93917764.8T priority patent/DK0654036T3/da
Priority to ES93917764T priority patent/ES2104163T3/es
Priority to DE59306286T priority patent/DE59306286D1/de
Priority to EP93917764A priority patent/EP0654036B1/de
Priority to ZA935718A priority patent/ZA935718B/xx
Priority to KR1019950700463A priority patent/KR100243440B1/ko
Priority to HU9500374A priority patent/HUT72605A/hu
Priority to JP50502594A priority patent/JP3479299B2/ja
Priority to PCT/EP1993/002101 priority patent/WO1994003465A1/de
Priority to AU47082/93A priority patent/AU672994B2/en
Priority to CA002141030A priority patent/CA2141030A1/en
Priority to NZ254813A priority patent/NZ254813A/en
Priority to AT93917764T priority patent/ATE152114T1/de
Priority to CN93107987A priority patent/CN1040984C/zh
Publication of DE4226279A1 publication Critical patent/DE4226279A1/de
Priority to FI950533A priority patent/FI109699B/fi
Priority to NO950445A priority patent/NO304986B1/no
Priority to GR970401610T priority patent/GR3023960T3/el
Priority to US09/209,484 priority patent/US6080734A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE4226279A 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel Withdrawn DE4226279A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4226279A DE4226279A1 (de) 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
TW082105422A TW306924B (enExample) 1992-08-08 1993-07-07
MX9304676A MX9304676A (es) 1992-08-08 1993-08-03 Liponucleosidos de seco-nucleosidos, procedimiento para su preparacion y composiciones con actividad antiviral que los contienen.
IL106588A IL106588A (en) 1992-08-08 1993-08-04 Phospholipids of seco- nucleosides, processes for the preparation thereof and pharmaceutical compositions with antiviral action containing them
JP50502594A JP3479299B2 (ja) 1992-08-08 1993-08-06 セコ‐ヌクレオシドのリポヌクレオチド、その製法及びその抗ウィルス製剤としての使用
AU47082/93A AU672994B2 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs
DE59306286T DE59306286D1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
EP93917764A EP0654036B1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
ZA935718A ZA935718B (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides and pharmaceutical compositions with antiviral action containing them
KR1019950700463A KR100243440B1 (ko) 1992-08-08 1993-08-06 세코-누클레오시드의 리포누클레오티드, 이들의 제조방법 및 항바이러스제로서 이들을 사용하는 방법
HU9500374A HUT72605A (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides their preparation and their use in antiviral pharmaceutical compositions
DK93917764.8T DK0654036T3 (da) 1992-08-08 1993-08-06 Liponukleotider af seco-nukleosider, deres fremstilling samt deres anvendelse som antivirale lægemidler.
PCT/EP1993/002101 WO1994003465A1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
ES93917764T ES2104163T3 (es) 1992-08-08 1993-08-06 Liponucleotidos de seco-nucleosidos, su preparacion al igual que su utilizacion como medicamentos antiviricos.
CA002141030A CA2141030A1 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
NZ254813A NZ254813A (en) 1992-08-08 1993-08-06 Liponucleotide derivatives of seco-nucleosides, their preparation and use as anti-viral drugs
AT93917764T ATE152114T1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
CN93107987A CN1040984C (zh) 1992-08-08 1993-08-07 断-核苷的脂核苷酸,它们的制备方法以及含有它们的具有抗病毒作用的药用组合物
FI950533A FI109699B (fi) 1992-08-08 1995-02-07 Menetelmä farmakologisesti aktiivisten seco-nukleosidien liponukleotidien valmistamiseksi
NO950445A NO304986B1 (no) 1992-08-08 1995-02-07 Liponukleotider av sekonukleosider, legemidler som inneholder dem, og deres anvendelse til fremstilling av antiviruslegemidler
GR970401610T GR3023960T3 (en) 1992-08-08 1997-06-30 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs.
US09/209,484 US6080734A (en) 1992-08-08 1998-12-11 Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4226279A DE4226279A1 (de) 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Publications (1)

Publication Number Publication Date
DE4226279A1 true DE4226279A1 (de) 1994-02-10

Family

ID=6465143

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4226279A Withdrawn DE4226279A1 (de) 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE59306286T Expired - Fee Related DE59306286D1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59306286T Expired - Fee Related DE59306286D1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Country Status (20)

Country Link
EP (1) EP0654036B1 (enExample)
JP (1) JP3479299B2 (enExample)
KR (1) KR100243440B1 (enExample)
CN (1) CN1040984C (enExample)
AT (1) ATE152114T1 (enExample)
AU (1) AU672994B2 (enExample)
CA (1) CA2141030A1 (enExample)
DE (2) DE4226279A1 (enExample)
DK (1) DK0654036T3 (enExample)
ES (1) ES2104163T3 (enExample)
FI (1) FI109699B (enExample)
GR (1) GR3023960T3 (enExample)
HU (1) HUT72605A (enExample)
IL (1) IL106588A (enExample)
MX (1) MX9304676A (enExample)
NO (1) NO304986B1 (enExample)
NZ (1) NZ254813A (enExample)
TW (1) TW306924B (enExample)
WO (1) WO1994003465A1 (enExample)
ZA (1) ZA935718B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0837630A4 (en) * 1995-06-07 1998-11-25 Univ California PRODRUGS BY PHARMACEUTICALS WITH INCREASED AVAILABILITY

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
DE4402492A1 (de) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern
KR100389558B1 (ko) * 2000-10-11 2003-06-27 주식회사 한스환경엔지니어링 유리섬유 강화플라스틱 성형품의 표면처리용 직물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0837630A4 (en) * 1995-06-07 1998-11-25 Univ California PRODRUGS BY PHARMACEUTICALS WITH INCREASED AVAILABILITY
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability

Also Published As

Publication number Publication date
DK0654036T3 (da) 1997-11-03
NO950445L (no) 1995-02-07
HU9500374D0 (en) 1995-03-28
EP0654036A1 (de) 1995-05-24
HUT72605A (en) 1996-05-28
WO1994003465A1 (de) 1994-02-17
FI109699B (fi) 2002-09-30
MX9304676A (es) 1994-03-31
KR100243440B1 (ko) 2000-03-02
JPH08500345A (ja) 1996-01-16
KR950702998A (ko) 1995-08-23
TW306924B (enExample) 1997-06-01
IL106588A0 (en) 1993-12-08
ZA935718B (en) 1995-02-06
AU4708293A (en) 1994-03-03
IL106588A (en) 1998-01-04
GR3023960T3 (en) 1997-09-30
FI950533A0 (fi) 1995-02-07
EP0654036B1 (de) 1997-04-23
ES2104163T3 (es) 1997-10-01
DE59306286D1 (de) 1997-05-28
AU672994B2 (en) 1996-10-24
JP3479299B2 (ja) 2003-12-15
CN1040984C (zh) 1998-12-02
NO950445D0 (no) 1995-02-07
CN1085908A (zh) 1994-04-27
CA2141030A1 (en) 1994-02-09
NO304986B1 (no) 1999-03-15
NZ254813A (en) 1996-05-28
FI950533L (fi) 1995-02-07
ATE152114T1 (de) 1997-05-15

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE

8139 Disposal/non-payment of the annual fee