CN1040984C - 断-核苷的脂核苷酸,它们的制备方法以及含有它们的具有抗病毒作用的药用组合物 - Google Patents

断-核苷的脂核苷酸,它们的制备方法以及含有它们的具有抗病毒作用的药用组合物 Download PDF

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Publication number
CN1040984C
CN1040984C CN93107987A CN93107987A CN1040984C CN 1040984 C CN1040984 C CN 1040984C CN 93107987 A CN93107987 A CN 93107987A CN 93107987 A CN93107987 A CN 93107987A CN 1040984 C CN1040984 C CN 1040984C
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CN
China
Prior art keywords
group
general formula
oxygen
lipid
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93107987A
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English (en)
Chinese (zh)
Other versions
CN1085908A (zh
Inventor
H·齐尔希
D·赫尔曼
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Roche Diagnostics GmbH
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Boehringer Mannheim GmbH
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Publication of CN1085908A publication Critical patent/CN1085908A/zh
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Publication of CN1040984C publication Critical patent/CN1040984C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN93107987A 1992-08-08 1993-08-07 断-核苷的脂核苷酸,它们的制备方法以及含有它们的具有抗病毒作用的药用组合物 Expired - Fee Related CN1040984C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4226279.8 1992-08-08
DE4226279A DE4226279A1 (de) 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Publications (2)

Publication Number Publication Date
CN1085908A CN1085908A (zh) 1994-04-27
CN1040984C true CN1040984C (zh) 1998-12-02

Family

ID=6465143

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93107987A Expired - Fee Related CN1040984C (zh) 1992-08-08 1993-08-07 断-核苷的脂核苷酸,它们的制备方法以及含有它们的具有抗病毒作用的药用组合物

Country Status (20)

Country Link
EP (1) EP0654036B1 (enExample)
JP (1) JP3479299B2 (enExample)
KR (1) KR100243440B1 (enExample)
CN (1) CN1040984C (enExample)
AT (1) ATE152114T1 (enExample)
AU (1) AU672994B2 (enExample)
CA (1) CA2141030A1 (enExample)
DE (2) DE4226279A1 (enExample)
DK (1) DK0654036T3 (enExample)
ES (1) ES2104163T3 (enExample)
FI (1) FI109699B (enExample)
GR (1) GR3023960T3 (enExample)
HU (1) HUT72605A (enExample)
IL (1) IL106588A (enExample)
MX (1) MX9304676A (enExample)
NO (1) NO304986B1 (enExample)
NZ (1) NZ254813A (enExample)
TW (1) TW306924B (enExample)
WO (1) WO1994003465A1 (enExample)
ZA (1) ZA935718B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
DE4402492A1 (de) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern
US7517858B1 (en) * 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
KR100389558B1 (ko) * 2000-10-11 2003-06-27 주식회사 한스환경엔지니어링 유리섬유 강화플라스틱 성형품의 표면처리용 직물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350287A2 (en) * 1988-07-07 1990-01-10 NeXstar Pharmaceuticals, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
WO1992003462A1 (de) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350287A2 (en) * 1988-07-07 1990-01-10 NeXstar Pharmaceuticals, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
WO1992003462A1 (de) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACTA CHEMICAL SCANDINAVICA BD. B39,(1),1985,PP47-54 1985.1.1 C.J.WELCH THE CHEMICAL SYNTHESIS AND ANTIMIRAL PROPERTIES OF AN ACYC *

Also Published As

Publication number Publication date
DK0654036T3 (da) 1997-11-03
NO950445L (no) 1995-02-07
HU9500374D0 (en) 1995-03-28
EP0654036A1 (de) 1995-05-24
HUT72605A (en) 1996-05-28
WO1994003465A1 (de) 1994-02-17
FI109699B (fi) 2002-09-30
MX9304676A (es) 1994-03-31
KR100243440B1 (ko) 2000-03-02
JPH08500345A (ja) 1996-01-16
KR950702998A (ko) 1995-08-23
TW306924B (enExample) 1997-06-01
DE4226279A1 (de) 1994-02-10
IL106588A0 (en) 1993-12-08
ZA935718B (en) 1995-02-06
AU4708293A (en) 1994-03-03
IL106588A (en) 1998-01-04
GR3023960T3 (en) 1997-09-30
FI950533A0 (fi) 1995-02-07
EP0654036B1 (de) 1997-04-23
ES2104163T3 (es) 1997-10-01
DE59306286D1 (de) 1997-05-28
AU672994B2 (en) 1996-10-24
JP3479299B2 (ja) 2003-12-15
NO950445D0 (no) 1995-02-07
CN1085908A (zh) 1994-04-27
CA2141030A1 (en) 1994-02-09
NO304986B1 (no) 1999-03-15
NZ254813A (en) 1996-05-28
FI950533L (fi) 1995-02-07
ATE152114T1 (de) 1997-05-15

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Free format text: CORRECT: PATENTEE; FROM: BOEHRINGER MANNHEIM GMBH TO: LROGGE DIAGNOSIS EQUIPMENT CO., LTD.

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee