DE4136389C2 - - Google Patents

Info

Publication number
DE4136389C2
DE4136389C2 DE4136389A DE4136389A DE4136389C2 DE 4136389 C2 DE4136389 C2 DE 4136389C2 DE 4136389 A DE4136389 A DE 4136389A DE 4136389 A DE4136389 A DE 4136389A DE 4136389 C2 DE4136389 C2 DE 4136389C2
Authority
DE
Germany
Prior art keywords
gene
plasmid
coli
expression
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE4136389A
Other languages
German (de)
English (en)
Other versions
DE4136389A1 (de
Inventor
Werner Dr. 6240 Koenigstein De Aretz
Ulrich Dr. 6272 Niedernhausen De Holst
Klaus Dr. 6232 Bad Soden De Koller
Guenther Dr. 6230 Frankfurt De Riess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE4136389A priority Critical patent/DE4136389A1/de
Priority to IL101258A priority patent/IL101258A0/xx
Priority to DK92104583.7T priority patent/DK0504798T3/da
Priority to ES92104583T priority patent/ES2096671T3/es
Priority to AT92104583T priority patent/ATE145238T1/de
Priority to DE59207509T priority patent/DE59207509D1/de
Priority to CA002063176A priority patent/CA2063176C/en
Priority to CN92101783A priority patent/CN1065292A/zh
Priority to EP92104583A priority patent/EP0504798B1/de
Priority to CS92804A priority patent/CZ284405B6/cs
Priority to SK804-92A priority patent/SK280242B6/sk
Priority to KR1019920004319A priority patent/KR100211002B1/ko
Priority to JP09220792A priority patent/JP3366664B2/ja
Publication of DE4136389A1 publication Critical patent/DE4136389A1/de
Application granted granted Critical
Publication of DE4136389C2 publication Critical patent/DE4136389C2/de
Priority to US08/312,675 priority patent/US5830743A/en
Priority to GR960402905T priority patent/GR3021610T3/el
Priority to HK98105878A priority patent/HK1006853A1/xx
Priority to CY9800033A priority patent/CY2115B1/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
DE4136389A 1991-03-18 1991-11-05 Verfahren zur herstellung von glutarylacylase in grossen mengen Granted DE4136389A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE4136389A DE4136389A1 (de) 1991-03-18 1991-11-05 Verfahren zur herstellung von glutarylacylase in grossen mengen
IL101258A IL101258A0 (en) 1991-03-18 1992-03-16 Process for the preparation of glutarylacylase in large quantities
KR1019920004319A KR100211002B1 (ko) 1991-03-18 1992-03-17 다량의 글루타릴아실라제를 제조하는 방법
AT92104583T ATE145238T1 (de) 1991-03-18 1992-03-17 Verfahren zur herstellung von glutarylacylase in grossen mengen
DE59207509T DE59207509D1 (de) 1991-03-18 1992-03-17 Verfahren zur Herstellung von Glutarylacylase in grossen Mengen
CA002063176A CA2063176C (en) 1991-03-18 1992-03-17 Process for the preparation of glutarylacylase in large quantities
CN92101783A CN1065292A (zh) 1991-03-18 1992-03-17 大量制备戊二酰酰基转移酶的方法
EP92104583A EP0504798B1 (de) 1991-03-18 1992-03-17 Verfahren zur Herstellung von Glutarylacylase in grossen Mengen
DK92104583.7T DK0504798T3 (da) 1991-03-18 1992-03-17 Fremgangsmåde til fremstilling af glutarylacylase i store mængder
SK804-92A SK280242B6 (sk) 1991-03-18 1992-03-17 Spôsob prípravy glutarylacylázy vo veľkých množstv
ES92104583T ES2096671T3 (es) 1991-03-18 1992-03-17 Procedimiento para la preparacion de glutarilacilasa en grandes cantidades.
CS92804A CZ284405B6 (cs) 1991-03-18 1992-03-17 Způsob přípravy glutarylacylázy ve velkých množstvích
JP09220792A JP3366664B2 (ja) 1991-03-18 1992-03-18 グルタリルアシラーゼの大量製造法
US08/312,675 US5830743A (en) 1991-03-18 1994-09-28 Process for the preparation of glutarylacylase in large quantities
GR960402905T GR3021610T3 (en) 1991-03-18 1996-11-14 Method of production of high amounts of glutaryl acyclase
HK98105878A HK1006853A1 (en) 1991-03-18 1998-06-22 Method of production of high amounts of glutaryl acyclase
CY9800033A CY2115B1 (en) 1991-03-18 1998-09-29 Method of production of high amounts of glutaryl a cyclase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4108823 1991-03-18
DE4136389A DE4136389A1 (de) 1991-03-18 1991-11-05 Verfahren zur herstellung von glutarylacylase in grossen mengen

Publications (2)

Publication Number Publication Date
DE4136389A1 DE4136389A1 (de) 1992-10-08
DE4136389C2 true DE4136389C2 (da) 1993-07-01

Family

ID=25902010

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4136389A Granted DE4136389A1 (de) 1991-03-18 1991-11-05 Verfahren zur herstellung von glutarylacylase in grossen mengen
DE59207509T Expired - Fee Related DE59207509D1 (de) 1991-03-18 1992-03-17 Verfahren zur Herstellung von Glutarylacylase in grossen Mengen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59207509T Expired - Fee Related DE59207509D1 (de) 1991-03-18 1992-03-17 Verfahren zur Herstellung von Glutarylacylase in grossen Mengen

Country Status (15)

Country Link
EP (1) EP0504798B1 (da)
JP (1) JP3366664B2 (da)
KR (1) KR100211002B1 (da)
CN (1) CN1065292A (da)
AT (1) ATE145238T1 (da)
CA (1) CA2063176C (da)
CY (1) CY2115B1 (da)
CZ (1) CZ284405B6 (da)
DE (2) DE4136389A1 (da)
DK (1) DK0504798T3 (da)
ES (1) ES2096671T3 (da)
GR (1) GR3021610T3 (da)
HK (1) HK1006853A1 (da)
IL (1) IL101258A0 (da)
SK (1) SK280242B6 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4337787A1 (de) * 1993-11-05 1995-05-11 Hoechst Ag Sauerstoffabhängige Fermentation von Mikroorganismen
IT1269180B (it) * 1994-01-14 1997-03-21 Mini Ricerca Scient Tecnolog Processo per la produzione dell'enzima acido 7beta- (4-carbossibutanamido)-cefalosporanico acilasi
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
US5766871A (en) * 1996-11-27 1998-06-16 Food Industry Research And Development Institute Screening and characterization of glutaryl-7-aminocephalosporanic acid acylase
DE19915938A1 (de) 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
DE19924632B4 (de) 1999-05-28 2006-04-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Verzögerung der Desaktivierung von Glutarylamidase während einer Enzymkatalyse

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU194307B (en) * 1983-09-16 1988-01-28 Richter Gedeon Vegyeszet Process for producing plasmidvectors of high copy number
DE3926076A1 (de) * 1989-04-21 1990-10-25 Boehringer Mannheim Gmbh Rekombinante dna und expressionsvektor

Also Published As

Publication number Publication date
DK0504798T3 (da) 1997-04-07
SK280242B6 (sk) 1999-10-08
CZ284405B6 (cs) 1998-11-11
KR920018222A (ko) 1992-10-21
DE4136389A1 (de) 1992-10-08
DE59207509D1 (de) 1996-12-19
JP3366664B2 (ja) 2003-01-14
EP0504798A1 (de) 1992-09-23
ATE145238T1 (de) 1996-11-15
CA2063176C (en) 2004-06-01
EP0504798B1 (de) 1996-11-13
GR3021610T3 (en) 1997-02-28
HK1006853A1 (en) 1999-03-19
IL101258A0 (en) 1992-11-15
CS80492A3 (en) 1992-10-14
ES2096671T3 (es) 1997-03-16
CY2115B1 (en) 2002-04-26
KR100211002B1 (ko) 1999-07-15
CN1065292A (zh) 1992-10-14
JPH05207879A (ja) 1993-08-20
CA2063176A1 (en) 1992-09-19

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOCHEMIE GESELLSCHAFT M.B.H., KUNDL, AT

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: SANDOZ AG, BASEL, CH

8339 Ceased/non-payment of the annual fee