DE4123874C2 - Mehrfach-Proben-Filtrations-Plattenaufbau - Google Patents
Mehrfach-Proben-Filtrations-PlattenaufbauInfo
- Publication number
- DE4123874C2 DE4123874C2 DE4123874A DE4123874A DE4123874C2 DE 4123874 C2 DE4123874 C2 DE 4123874C2 DE 4123874 A DE4123874 A DE 4123874A DE 4123874 A DE4123874 A DE 4123874A DE 4123874 C2 DE4123874 C2 DE 4123874C2
- Authority
- DE
- Germany
- Prior art keywords
- plate
- drop guide
- openings
- structure according
- drop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001914 filtration Methods 0.000 title claims description 9
- 239000012528 membrane Substances 0.000 claims description 38
- 238000007789 sealing Methods 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000013011 mating Effects 0.000 claims 1
- 239000000463 material Substances 0.000 description 8
- 241000894007 species Species 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000008188 pellet Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241001524679 Escherichia virus M13 Species 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 2
- 229910001488 sodium perchlorate Inorganic materials 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 101150116749 chuk gene Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920003225 polyurethane elastomer Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Filtration Of Liquid (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/555,139 US5141719A (en) | 1990-07-18 | 1990-07-18 | Multi-sample filtration plate assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE4123874A1 DE4123874A1 (de) | 1992-01-23 |
| DE4123874C2 true DE4123874C2 (de) | 1996-09-19 |
Family
ID=24216127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4123874A Expired - Fee Related DE4123874C2 (de) | 1990-07-18 | 1991-07-18 | Mehrfach-Proben-Filtrations-Plattenaufbau |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5141719A (enExample) |
| JP (1) | JPH04227032A (enExample) |
| CA (1) | CA2043633C (enExample) |
| DE (1) | DE4123874C2 (enExample) |
| FR (1) | FR2664825A1 (enExample) |
| GB (1) | GB2246081B (enExample) |
| IT (1) | IT1250493B (enExample) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409832A (en) * | 1990-08-29 | 1995-04-25 | Stratecon Diagnostics International | Membrane holder for use in an assay device |
| US5227290A (en) * | 1990-08-29 | 1993-07-13 | Pocock Douglas A | Method for conducting diagnostic assays |
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| JP2947314B2 (ja) * | 1992-12-24 | 1999-09-13 | 株式会社クボタ | 吸着・反応装置 |
| US6258325B1 (en) * | 1993-04-19 | 2001-07-10 | Ashok Ramesh Sanadi | Method and apparatus for preventing cross-contamination of multi-well test plates |
| US5342581A (en) * | 1993-04-19 | 1994-08-30 | Sanadi Ashok R | Apparatus for preventing cross-contamination of multi-well test plates |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US5961926A (en) * | 1993-09-27 | 1999-10-05 | Packard Instrument Co., Inc. | Microplate assembly and method of preparing samples for analysis in a microplate assembly |
| WO1995027196A1 (en) * | 1994-04-04 | 1995-10-12 | Sanadi Ashok R | Method and apparatus for preventing cross-contamination of multi-well test plates |
| DE4412286A1 (de) * | 1994-04-09 | 1995-10-12 | Boehringer Mannheim Gmbh | System zur kontaminationsfreien Bearbeitung von Reaktionsabläufen |
| US5846493A (en) * | 1995-02-14 | 1998-12-08 | Promega Corporation | System for analyzing a substance from a solution following filtering of the substance from the solution |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| DE19514521A1 (de) * | 1995-04-12 | 1996-10-17 | Schulz Hans Joachim Dr | Laborgerät zur gleichzeitigen, mauellen Durchführung mehrerer chemischer Reaktionen nach einem Stecksystem |
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| US5620894A (en) * | 1995-06-16 | 1997-04-15 | Glaxo Wellcome Inc. | Apparatus for automated biological cell harvesting |
| JP2832586B2 (ja) * | 1995-08-04 | 1998-12-09 | 株式会社トミー精工 | Ｄｎａ抽出精製方法 |
| WO1997010055A1 (en) * | 1995-09-15 | 1997-03-20 | Beckman Instruments, Inc. | Vacuum manifold for laboratory processing of multiple liquid samples |
| US5888830A (en) | 1995-09-22 | 1999-03-30 | Berlex Laboratories, Inc. | Apparatus and process for multiple chemical reactions |
| US6331431B1 (en) * | 1995-11-28 | 2001-12-18 | Ixsys, Inc. | Vacuum device and method for isolating periplasmic fraction from cells |
| US6045760A (en) * | 1995-12-05 | 2000-04-04 | Hitachi Koki Co., Ltd. | Micro-plate adapter |
| US5840256A (en) * | 1996-04-09 | 1998-11-24 | David Sarnoff Research Center Inc. | Plate for reaction system |
| US5753187A (en) * | 1996-06-14 | 1998-05-19 | Stovall Life Science, Inc. | Combinatorial chemistry cassette |
| US5958714A (en) * | 1996-10-02 | 1999-09-28 | Safety Associates, Inc. | Test kits for determining at least two specific analytes in foods and other complex matrices |
| EP0929361A4 (en) * | 1996-10-04 | 2000-07-19 | Whatman Inc | DEVICE AND METHOD FOR SIMULTANEOUS MULTIPLE SYNTHESIS |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| WO1998031466A1 (en) * | 1997-01-17 | 1998-07-23 | Corning Incorporated | Multi-well plate |
| NZ336924A (en) * | 1997-02-13 | 2001-06-29 | Bone Care Int Inc | Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| DE29709916U1 (de) * | 1997-06-06 | 1997-07-24 | Macherey, Nagel GmbH & Co. Handelsgesellschaft, 52355 Düren | Vorrichtung zum Trennen von Substanzen mittels Unterdruck |
| US6391241B1 (en) * | 1997-06-06 | 2002-05-21 | Corning Incorporated | Method of manufacture for a multiwell plate and/or filter plate |
| DE19734135A1 (de) * | 1997-08-07 | 1999-02-11 | Boehringer Mannheim Gmbh | System zum Zurverfügungstellen biologischer Materialien |
| US5955682A (en) * | 1997-11-12 | 1999-09-21 | Federal Air Conditioning Technologies, Inc. | Portable sensor manifold for air conditioning diagnostics |
| EP1037044B1 (en) * | 1997-12-02 | 2011-07-20 | Hitachi Chemical Company, Ltd. | Method for measuring iodine using an hermetically sealed reaction instrument for specimen pretreatment |
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| WO1999043433A2 (en) * | 1998-02-27 | 1999-09-02 | Pall Corporation | Devices and methods for test sample preparation |
| WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US6309608B1 (en) * | 1998-04-23 | 2001-10-30 | Stephen Matson | Method and apparatus for organic synthesis |
| DE29811606U1 (de) * | 1998-06-29 | 1999-05-06 | Sension, biologische Detektions- und Schnelltestsysteme GmbH, 86167 Augsburg | Kombi-Vorrichtung zur simultanen Durchführung von Immunfiltrationstests |
| US6436351B1 (en) * | 1998-07-15 | 2002-08-20 | Deltagen Research Laboratories, L.L.C. | Microtitre chemical reaction system |
| US6159368A (en) * | 1998-10-29 | 2000-12-12 | The Perkin-Elmer Corporation | Multi-well microfiltration apparatus |
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| US6869572B1 (en) * | 1999-09-13 | 2005-03-22 | Millipore Corporation | High density cast-in-place sample preparation card |
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| DE60139469D1 (de) * | 2000-05-18 | 2009-09-17 | Millipore Corp | Mehrfachlochplatte mit durch klebe verbundenem filter |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3390962A (en) * | 1965-09-01 | 1968-07-02 | Nat Instr Lab Inc | Biochemical test plate |
| US3378481A (en) * | 1966-01-03 | 1968-04-16 | Calvin A. Saravis | Biochemical test plate |
| US4427415A (en) * | 1979-01-05 | 1984-01-24 | Cleveland Patrick H | Manifold vacuum biochemical test method and device |
| US4734192A (en) * | 1982-07-01 | 1988-03-29 | Millipore Corporation | Multiwell membrane filtration apparatus |
| US4493815A (en) * | 1983-07-28 | 1985-01-15 | Bio-Rad Laboratories, Inc. | Supporting and filtering biochemical test plate assembly |
| GB2176601B (en) * | 1985-06-10 | 1989-02-01 | Bio Rad Laboratories | Test plate assembly defining discrete regions on a microporous membrane with low boundary distortion |
| DE3622848A1 (de) * | 1986-07-08 | 1988-01-21 | Fresenius Inst | Vorrichtung zur membranfiltration |
| US4895706A (en) * | 1986-10-28 | 1990-01-23 | Costar Corporation | Multi-well filter strip and composite assemblies |
| US4948564A (en) * | 1986-10-28 | 1990-08-14 | Costar Corporation | Multi-well filter strip and composite assemblies |
| US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
-
1990
- 1990-07-18 US US07/555,139 patent/US5141719A/en not_active Expired - Fee Related
-
1991
- 1991-05-27 JP JP3120941A patent/JPH04227032A/ja active Pending
- 1991-05-31 CA CA002043633A patent/CA2043633C/en not_active Expired - Fee Related
- 1991-07-09 FR FR9108597A patent/FR2664825A1/fr active Granted
- 1991-07-11 IT ITRM910512A patent/IT1250493B/it active IP Right Grant
- 1991-07-12 GB GB9115091A patent/GB2246081B/en not_active Expired - Fee Related
- 1991-07-18 DE DE4123874A patent/DE4123874C2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2664825A1 (fr) | 1992-01-24 |
| FR2664825B1 (enExample) | 1994-08-19 |
| IT1250493B (it) | 1995-04-08 |
| DE4123874A1 (de) | 1992-01-23 |
| ITRM910512A0 (it) | 1991-07-11 |
| GB2246081B (en) | 1994-11-16 |
| ITRM910512A1 (it) | 1993-01-11 |
| GB9115091D0 (en) | 1991-08-28 |
| JPH04227032A (ja) | 1992-08-17 |
| GB2246081A (en) | 1992-01-22 |
| US5141719A (en) | 1992-08-25 |
| CA2043633A1 (en) | 1992-01-19 |
| CA2043633C (en) | 1993-12-21 |
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