DE3875848T2 - Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen. - Google Patents

Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen.

Info

Publication number
DE3875848T2
DE3875848T2 DE8888307191T DE3875848T DE3875848T2 DE 3875848 T2 DE3875848 T2 DE 3875848T2 DE 8888307191 T DE8888307191 T DE 8888307191T DE 3875848 T DE3875848 T DE 3875848T DE 3875848 T2 DE3875848 T2 DE 3875848T2
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
compound
carbamoyl
vanadium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE8888307191T
Other languages
German (de)
English (en)
Other versions
DE3875848D1 (de
Inventor
Norio Iwano
Masayasu Kato
Yoshio Toyoshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16330618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3875848(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE3875848D1 publication Critical patent/DE3875848D1/de
Application granted granted Critical
Publication of DE3875848T2 publication Critical patent/DE3875848T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8888307191T 1987-08-04 1988-08-03 Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen. Revoked DE3875848T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19480987 1987-08-04

Publications (2)

Publication Number Publication Date
DE3875848D1 DE3875848D1 (de) 1992-12-17
DE3875848T2 true DE3875848T2 (de) 1993-03-25

Family

ID=16330618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888307191T Revoked DE3875848T2 (de) 1987-08-04 1988-08-03 Herstellung von 2-(2-pyridylmethylsulfinyl)-benzimidazol-verbindungen.

Country Status (11)

Country Link
US (1) US5578732A (enExample)
EP (1) EP0302720B1 (enExample)
KR (1) KR960000047B1 (enExample)
AT (1) ATE82283T1 (enExample)
CA (1) CA1263119A (enExample)
DE (1) DE3875848T2 (enExample)
DK (1) DK171989B1 (enExample)
ES (1) ES2052728T3 (enExample)
GR (1) GR3006974T3 (enExample)
HU (1) HU199828B (enExample)
IE (1) IE61717B1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US5312824A (en) 1990-10-17 1994-05-17 Takeda Chemical Industries, Ltd. Certain 2-[(4-difluoromethoxy-2-pyridyl)-methylthio or methylsulfinyl-5-benzimidazoles useful for treating peptic ulcers
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WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
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ES2063705B1 (es) * 1993-06-14 1995-07-16 S A L V A T Lab Sa Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion.
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US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
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US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
TWI275587B (en) 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
PL333847A1 (en) * 1999-06-18 2001-01-02 Inst Farmaceutyczny Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
ES2240113T3 (es) 1999-06-30 2005-10-16 Takeda Pharmaceutical Company Limited Cristales de lansoprazol.
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
KR100362947B1 (ko) * 1999-09-21 2002-11-30 주식회사 대웅 설폭시드 화합물의 제조방법
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
EP2281821B1 (en) 2000-05-15 2014-10-22 Takeda Pharmaceutical Company Limited Process for producing a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
CN1254473C (zh) * 2000-12-01 2006-05-03 武田药品工业株式会社 (r)－或(s)－兰索拉唑的结晶方法
CZ20032351A3 (cs) 2001-02-02 2004-08-18 Tevaápharmaceuticaláindustriesáltd Způsob výroby substituovaných @@}@@pyridylmethylB sulfinyl @�H@benzimidazolů
KR100430575B1 (ko) * 2001-02-21 2004-05-10 주식회사 씨트리 란소프라졸 및 그 중간체의 제조방법
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
US20040248941A1 (en) * 2001-09-25 2004-12-09 Keiji Kamiyama Benzimidazone compound, process for producing the same, and use thereof
AU2003224779A1 (en) * 2002-03-27 2003-10-13 Teva Pharmaceutical Industries Ltd. Lansoprazole polymorphs and processes for preparation thereof
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
WO2004011455A1 (en) * 2002-07-26 2004-02-05 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
EP1837335A1 (en) * 2002-08-21 2007-09-26 Teva Pharmaceutical Industries Ltd A method for the purification of Lansoprazole
DE60316791T2 (de) * 2002-08-21 2008-07-24 Teva Pharmaceutical Industries Ltd. Verfahren zur aufreinigung von lanzoprazol
WO2004035052A1 (ja) * 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited 安定な固形製剤
AU2003294405A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
CA2510849A1 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
JP2006516574A (ja) * 2003-02-05 2006-07-06 テバ ファーマシューティカル インダストリーズ リミティド ランソプラゾール安定化方法
WO2004087702A2 (fr) * 2003-03-28 2004-10-14 Sidem Pharma Procede de preparation enantioselective de derives de sulfoxydes.
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
MXPA05013316A (es) 2003-06-10 2006-03-17 Teva Pharma Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
CA2570916C (en) 2004-06-16 2013-06-11 Tap Pharmaceutical Products, Inc. Pulsed release dosage form of a ppi
JP5173191B2 (ja) 2004-09-13 2013-03-27 武田薬品工業株式会社 酸化化合物の製造方法及び製造装置
EP1681056A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
KR100758600B1 (ko) * 2006-01-05 2007-09-13 주식회사 대웅제약 란소프라졸 결정형 ａ의 제조방법
WO2008035189A1 (en) * 2006-09-22 2008-03-27 Orchid Chemicals & Pharmaceuticals Limited A method for the purification of lansoprazole
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
JP5629581B2 (ja) 2007-10-12 2014-11-19 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド 食物の摂取から独立した消化器疾患の治療方法
UY31695A (es) 2008-03-10 2009-11-10 Takeda Pharmaceutical Cristal de compuestos de bencimidazol
ES2343935B1 (es) * 2008-12-29 2011-04-28 Laboratorios Viñas S.A. Intermedios utiles para la obtencion de 2-(2-piridinilmetilsulfinil)-1h-benzimidazoles y procedimientos correspondientes.
KR20100101405A (ko) * 2009-03-09 2010-09-17 한미홀딩스 주식회사 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102180865B (zh) * 2011-03-17 2013-01-16 浙江工业大学 一种兰索拉唑的合成方法
US9119769B2 (en) 2011-12-30 2015-09-01 The Curators Of The University Of Missouri Method for transforming pharmaceutical crystal forms
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
CN103724325B (zh) * 2013-12-10 2016-04-13 南京工业大学 制备亚磺酰基-1-氢-苯并咪唑衍生物的方法
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺
CN116891458A (zh) * 2023-06-19 2023-10-17 南京唯创远医药科技有限公司 一种艾普拉唑的制备方法

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

Also Published As

Publication number Publication date
EP0302720B1 (en) 1992-11-11
CA1263119A (en) 1989-11-21
KR960000047B1 (ko) 1996-01-03
EP0302720A1 (en) 1989-02-08
DE3875848D1 (de) 1992-12-17
DK171989B1 (da) 1997-09-08
HU199828B (en) 1990-03-28
IE61717B1 (en) 1994-11-30
DK428188A (da) 1989-02-05
ATE82283T1 (de) 1992-11-15
DK428188D0 (da) 1988-08-01
HUT49346A (en) 1989-09-28
IE882376L (en) 1989-02-04
US5578732A (en) 1996-11-26
ES2052728T3 (es) 1994-07-16
GR3006974T3 (enExample) 1993-06-30
KR890003738A (ko) 1989-04-17

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8331 Complete revocation