DE3854110D1 - 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung. - Google Patents

2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.

Info

Publication number
DE3854110D1
DE3854110D1 DE3854110T DE3854110T DE3854110D1 DE 3854110 D1 DE3854110 D1 DE 3854110D1 DE 3854110 T DE3854110 T DE 3854110T DE 3854110 T DE3854110 T DE 3854110T DE 3854110 D1 DE3854110 D1 DE 3854110D1
Authority
DE
Germany
Prior art keywords
alkyliden
production
amino
pyrimidine nucleoside
nucleoside derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3854110T
Other languages
English (en)
Other versions
DE3854110T2 (de
Inventor
Akira Minamishinkawa K Matsuda
Toru Ueda
Kenji Takenuki
Haruhiko Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62065405A external-priority patent/JPS63230699A/ja
Priority claimed from JP63020032A external-priority patent/JPH0633313B2/ja
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Publication of DE3854110D1 publication Critical patent/DE3854110D1/de
Application granted granted Critical
Publication of DE3854110T2 publication Critical patent/DE3854110T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE3854110T 1987-03-19 1988-03-17 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung. Expired - Fee Related DE3854110T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62065405A JPS63230699A (ja) 1987-03-19 1987-03-19 ２’−アルキリデンピリミジンヌクレオシド誘導体
JP63020032A JPH0633313B2 (ja) 1988-01-30 1988-01-30 ２´−アルキリデンシチジン誘導体の製造法
PCT/JP1988/000278 WO1988007049A1 (en) 1987-03-19 1988-03-17 2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use

Publications (2)

Publication Number Publication Date
DE3854110D1 true DE3854110D1 (de) 1995-08-10
DE3854110T2 DE3854110T2 (de) 1995-11-30

Family

ID=26356923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3854110T Expired - Fee Related DE3854110T2 (de) 1987-03-19 1988-03-17 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.

Country Status (6)

Country Link
US (3) US5047520A (de)
EP (1) EP0310673B1 (de)
KR (1) KR910008800B1 (de)
AT (1) ATE124702T1 (de)
DE (1) DE3854110T2 (de)
WO (1) WO1988007049A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE124702T1 (de) * 1987-03-19 1995-07-15 Yamasa Shoyu Kk 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
US5401726A (en) * 1988-08-25 1995-03-28 Yoshitomi Pharaceutical Industries, Ltd. 2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
ATE154359T1 (de) * 1988-08-25 1997-06-15 Yoshitomi Pharmaceutical 2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
US5607925A (en) * 1988-11-15 1997-03-04 Merrell Pharmaceuticals Inc. Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
MX9203459A (es) * 1988-11-15 1992-08-01 Merrell Pharma Inc Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
US5616702A (en) * 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
EP0373485B1 (de) * 1988-12-07 1995-05-31 Yamasa Shoyu Co., Ltd. Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5639647A (en) * 1994-03-29 1997-06-17 Ribozyme Pharmaceuticals, Inc. 2'-deoxy-2'alkylnucleotide containing nucleic acid
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO1996001834A1 (fr) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside
CA2171518A1 (en) * 1995-03-24 1996-09-25 Douglas Patton Kjell Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US5633367A (en) * 1995-03-24 1997-05-27 Eli Lilly And Company Process for the preparation of a 2-substituted 3,3-difluorofuran
KR100601973B1 (ko) 2004-11-25 2006-07-18 삼성전자주식회사 나노 입자를 이용한 나노 스케일의 반도체 소자의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
JPS584780A (ja) * 1981-06-29 1983-01-11 Sankyo Kagaku Kk ４′，５′−不飽和ヌクレオシドの合成法
ATE124702T1 (de) * 1987-03-19 1995-07-15 Yamasa Shoyu Kk 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
EP0373485B1 (de) * 1988-12-07 1995-05-31 Yamasa Shoyu Co., Ltd. Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden

Also Published As

Publication number Publication date
KR890700598A (ko) 1989-04-26
KR910008800B1 (ko) 1991-10-21
US5300636A (en) 1994-04-05
ATE124702T1 (de) 1995-07-15
DE3854110T2 (de) 1995-11-30
US5047520A (en) 1991-09-10
EP0310673B1 (de) 1995-07-05
US5430139A (en) 1995-07-04
EP0310673A1 (de) 1989-04-12
WO1988007049A1 (en) 1988-09-22
EP0310673A4 (en) 1990-10-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee