ATE124702T1 - 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung. - Google Patents

2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.

Info

Publication number
ATE124702T1
ATE124702T1 AT88902560T AT88902560T ATE124702T1 AT E124702 T1 ATE124702 T1 AT E124702T1 AT 88902560 T AT88902560 T AT 88902560T AT 88902560 T AT88902560 T AT 88902560T AT E124702 T1 ATE124702 T1 AT E124702T1
Authority
AT
Austria
Prior art keywords
alkylide
preparation
amino
pyrimidine nucleoside
nucleoside derivatives
Prior art date
Application number
AT88902560T
Other languages
English (en)
Inventor
Akira Minamishinkawa K Matsuda
Nishi -Chome K Monbusho-Youchi
Toru Ueda
Kenji Takenuki
Haruhiko Machida
Original Assignee
Yamasa Shoyu Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62065405A external-priority patent/JPS63230699A/ja
Priority claimed from JP63020032A external-priority patent/JPH0633313B2/ja
Application filed by Yamasa Shoyu Kk filed Critical Yamasa Shoyu Kk
Application granted granted Critical
Publication of ATE124702T1 publication Critical patent/ATE124702T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88902560T 1987-03-19 1988-03-17 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung. ATE124702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62065405A JPS63230699A (ja) 1987-03-19 1987-03-19 ２’−アルキリデンピリミジンヌクレオシド誘導体
JP63020032A JPH0633313B2 (ja) 1988-01-30 1988-01-30 ２´−アルキリデンシチジン誘導体の製造法

Publications (1)

Publication Number Publication Date
ATE124702T1 true ATE124702T1 (de) 1995-07-15

Family

ID=26356923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88902560T ATE124702T1 (de) 1987-03-19 1988-03-17 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.

Country Status (6)

Country Link
US (3) US5047520A (de)
EP (1) EP0310673B1 (de)
KR (1) KR910008800B1 (de)
AT (1) ATE124702T1 (de)
DE (1) DE3854110T2 (de)
WO (1) WO1988007049A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
US5401726A (en) * 1988-08-25 1995-03-28 Yoshitomi Pharaceutical Industries, Ltd. 2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
EP0566162B1 (de) * 1988-08-25 1997-06-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-Methylidenpyrimidinnukleosidverbindungen, ihre Verwendung und Verfahren zu ihrer Herstellung
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
MX9203459A (es) * 1988-11-15 1992-08-01 Merrell Pharma Inc Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
US5616702A (en) * 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives
US5607925A (en) * 1988-11-15 1997-03-04 Merrell Pharmaceuticals Inc. Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
DE68922899T2 (de) * 1988-12-07 1995-10-12 Yoshitomi Pharmaceutical Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden.
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5639647A (en) * 1994-03-29 1997-06-17 Ribozyme Pharmaceuticals, Inc. 2'-deoxy-2'alkylnucleotide containing nucleic acid
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
EP0770621A4 (de) * 1994-07-12 1998-01-28 Yamasa Corp 2'-deoxy-2'(substituiertes oder unsubstituiertes methylidene)-4-thionukleosid
US5633367A (en) * 1995-03-24 1997-05-27 Eli Lilly And Company Process for the preparation of a 2-substituted 3,3-difluorofuran
CA2171518A1 (en) * 1995-03-24 1996-09-25 Douglas Patton Kjell Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
KR100601973B1 (ko) 2004-11-25 2006-07-18 삼성전자주식회사 나노 입자를 이용한 나노 스케일의 반도체 소자의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
JPS584780A (ja) * 1981-06-29 1983-01-11 Sankyo Kagaku Kk ４′，５′−不飽和ヌクレオシドの合成法
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
DE68922899T2 (de) * 1988-12-07 1995-10-12 Yoshitomi Pharmaceutical Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden.

Also Published As

Publication number Publication date
US5430139A (en) 1995-07-04
EP0310673A1 (de) 1989-04-12
EP0310673B1 (de) 1995-07-05
KR910008800B1 (ko) 1991-10-21
EP0310673A4 (en) 1990-10-10
US5047520A (en) 1991-09-10
KR890700598A (ko) 1989-04-26
DE3854110T2 (de) 1995-11-30
DE3854110D1 (de) 1995-08-10
WO1988007049A1 (en) 1988-09-22
US5300636A (en) 1994-04-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee