YU128191A - Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata - Google Patents
Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijataInfo
- Publication number
- YU128191A YU128191A YU128191A YU128191A YU128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- acyl
- alkyl
- forskolin
- group
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
POSTUPAK ZA DOBIJANJE 6-ACILNIH, 7-ACILNIH I 6,7-DIACILNIH ANALOGA FORSKOLINA I NJEGOVIH INTERMEDIJATA, postupak za pripremu 6-acilnih, 7-acilnih ili 6,7-diacilnih analoga forskolina opšte formule gde su R1 i R2 jednaki ili različiti radikali i predstavljaju hidroksil, acetoksi, grupu, pri čemu je R3 vodonik ili alkil, n predsavlja ceo broj od 0 do 10, X predstavlja vodonik, halogen, alkil, ili grupu NR4R5 u kojoj R4 i R5, u slučaju da su jednaki predstavljaju vodonik ili alkil; u slučaju da nisu jednaki R4 predstavlja vodonik a R5 alkil, aril, aralkil ili substituisani alkil; R4 i R5 zajedno sa azotom, na koga su vezani, čine heterocikl, koji može da sadrži dodatni heteroatom, kao N, O, S ili više od jednog heteroatoma i u datom primeru može biti zamenjen na jednom ili više položaja halogenom, alkilom, hidroksi, alkoksi, karboksilom, nitro ili ciano grupom; ili grupom - OCONR6R7, pri čemu R6 i R7 imaju isto značenje kao što je gore definisano za R4 i R5; "a" predstavlja u datom primeru dodatnu vezu medju atomima ugljenika C-5 i C-6, pod uslovom, da u slučaju prisutnosti, predstavlja R1- samo vodonik, a R2 ima isti značaj kao što je gore definisano, uklanjanjem 1,9-0-izopropilidenske zaštitne grupe iz jedinjenja opšte formule II pri čemu R1, R2 i "a" imaju gore navedeno značenje uz podešenu vrednost pH rastvora na 1,0 do 3,5 pri intervalu temperature od 0В° do 80В°C za vreme od 72 časa i po želji dobijena jedinjenja možemo pretvoriti u njihove farmaceutsko prihvatljive soli.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90114126 | 1990-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU128191A true YU128191A (sh) | 1994-09-09 |
Family
ID=8204251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU128191A YU128191A (sh) | 1990-07-24 | 1991-07-22 | Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0468444A1 (sh) |
JP (1) | JPH04234380A (sh) |
KR (1) | KR920002575A (sh) |
CN (1) | CN1058402A (sh) |
AU (1) | AU8121091A (sh) |
CA (1) | CA2047616A1 (sh) |
CS (1) | CS231591A3 (sh) |
FI (1) | FI913508A (sh) |
HU (1) | HU208968B (sh) |
IE (1) | IE912594A1 (sh) |
IL (1) | IL98916A0 (sh) |
MX (1) | MX9100343A (sh) |
PL (1) | PL291198A1 (sh) |
YU (1) | YU128191A (sh) |
ZA (1) | ZA915761B (sh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0482885A (ja) * | 1990-07-23 | 1992-03-16 | Nippon Kayaku Co Ltd | 6―アシル―7―デアセチルフォルスコリン誘導体の新規な製造法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2614891B1 (fr) * | 1987-05-04 | 1991-05-24 | Roussel Uclaf | Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation |
-
1991
- 1991-07-22 IL IL98916A patent/IL98916A0/xx unknown
- 1991-07-22 YU YU128191A patent/YU128191A/sh unknown
- 1991-07-22 KR KR1019910012502A patent/KR920002575A/ko not_active Application Discontinuation
- 1991-07-22 FI FI913508A patent/FI913508A/fi unknown
- 1991-07-23 AU AU81210/91A patent/AU8121091A/en not_active Abandoned
- 1991-07-23 PL PL29119891A patent/PL291198A1/xx unknown
- 1991-07-23 EP EP91112325A patent/EP0468444A1/en not_active Withdrawn
- 1991-07-23 IE IE259491A patent/IE912594A1/en unknown
- 1991-07-23 JP JP3182433A patent/JPH04234380A/ja active Pending
- 1991-07-23 MX MX9100343A patent/MX9100343A/es unknown
- 1991-07-23 ZA ZA915761A patent/ZA915761B/xx unknown
- 1991-07-23 CN CN91105003A patent/CN1058402A/zh active Pending
- 1991-07-23 CA CA002047616A patent/CA2047616A1/en not_active Abandoned
- 1991-07-23 CS CS912315A patent/CS231591A3/cs unknown
- 1991-07-24 HU HU912491A patent/HU208968B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU8121091A (en) | 1992-01-30 |
EP0468444A1 (en) | 1992-01-29 |
HU208968B (en) | 1994-02-28 |
FI913508A (fi) | 1992-01-25 |
HUT59122A (en) | 1992-04-28 |
HU912491D0 (en) | 1991-12-30 |
PL291198A1 (en) | 1992-03-09 |
CS231591A3 (en) | 1992-02-19 |
KR920002575A (ko) | 1992-02-28 |
MX9100343A (es) | 1992-02-28 |
CN1058402A (zh) | 1992-02-05 |
FI913508A0 (fi) | 1991-07-22 |
IE912594A1 (en) | 1992-01-29 |
IL98916A0 (en) | 1992-07-15 |
CA2047616A1 (en) | 1992-01-25 |
ZA915761B (en) | 1992-04-29 |
JPH04234380A (ja) | 1992-08-24 |
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