YU128191A - Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata - Google Patents

Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata

Info

Publication number
YU128191A
YU128191A YU128191A YU128191A YU128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A YU 128191 A YU128191 A YU 128191A
Authority
YU
Yugoslavia
Prior art keywords
acyl
alkyl
forskolin
group
preparation
Prior art date
Application number
YU128191A
Other languages
English (en)
Inventor
N.J. Souza
P.D. Desai
S.V. Savanur
J. Blumbach
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of YU128191A publication Critical patent/YU128191A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 6-ACILNIH, 7-ACILNIH I 6,7-DIACILNIH ANALOGA FORSKOLINA I NJEGOVIH INTERMEDIJATA, postupak za pripremu 6-acilnih, 7-acilnih ili 6,7-diacilnih analoga forskolina opšte formule gde su R1 i R2 jednaki ili različiti radikali i predstavljaju hidroksil, acetoksi, grupu, pri čemu je R3 vodonik ili alkil, n predsavlja ceo broj od 0 do 10, X predstavlja vodonik, halogen, alkil, ili grupu NR4R5 u kojoj R4 i R5, u slučaju da su jednaki predstavljaju vodonik ili alkil; u slučaju da nisu jednaki R4 predstavlja vodonik a R5 alkil, aril, aralkil ili substituisani alkil; R4 i R5 zajedno sa azotom, na koga su vezani, čine heterocikl, koji može da sadrži dodatni heteroatom, kao N, O, S ili više od jednog heteroatoma i u datom primeru može biti zamenjen na jednom ili više položaja halogenom, alkilom, hidroksi, alkoksi, karboksilom, nitro ili ciano grupom; ili grupom - OCONR6R7, pri čemu R6 i R7 imaju isto značenje kao što je gore definisano za R4 i R5; "a" predstavlja u datom primeru dodatnu vezu medju atomima ugljenika C-5 i C-6, pod uslovom, da u slučaju prisutnosti, predstavlja R1- samo vodonik, a R2 ima isti značaj kao što je gore definisano, uklanjanjem 1,9-0-izopropilidenske zaštitne grupe iz jedinjenja opšte formule II pri čemu R1, R2 i "a" imaju gore navedeno značenje uz podešenu vrednost pH rastvora na 1,0 do 3,5 pri intervalu temperature od 0В° do 80В°C za vreme od 72 časa i po želji dobijena jedinjenja možemo pretvoriti u njihove farmaceutsko prihvatljive soli.
YU128191A 1990-07-24 1991-07-22 Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata YU128191A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90114126 1990-07-24

Publications (1)

Publication Number Publication Date
YU128191A true YU128191A (sh) 1994-09-09

Family

ID=8204251

Family Applications (1)

Application Number Title Priority Date Filing Date
YU128191A YU128191A (sh) 1990-07-24 1991-07-22 Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata

Country Status (15)

Country Link
EP (1) EP0468444A1 (sh)
JP (1) JPH04234380A (sh)
KR (1) KR920002575A (sh)
CN (1) CN1058402A (sh)
AU (1) AU8121091A (sh)
CA (1) CA2047616A1 (sh)
CS (1) CS231591A3 (sh)
FI (1) FI913508A (sh)
HU (1) HU208968B (sh)
IE (1) IE912594A1 (sh)
IL (1) IL98916A0 (sh)
MX (1) MX9100343A (sh)
PL (1) PL291198A1 (sh)
YU (1) YU128191A (sh)
ZA (1) ZA915761B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0482885A (ja) * 1990-07-23 1992-03-16 Nippon Kayaku Co Ltd ６―アシル―７―デアセチルフォルスコリン誘導体の新規な製造法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614891B1 (fr) * 1987-05-04 1991-05-24 Roussel Uclaf Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation

Also Published As

Publication number Publication date
CN1058402A (zh) 1992-02-05
HU208968B (en) 1994-02-28
FI913508A0 (fi) 1991-07-22
PL291198A1 (en) 1992-03-09
CA2047616A1 (en) 1992-01-25
HU912491D0 (en) 1991-12-30
AU8121091A (en) 1992-01-30
KR920002575A (ko) 1992-02-28
FI913508A (fi) 1992-01-25
CS231591A3 (en) 1992-02-19
EP0468444A1 (en) 1992-01-29
ZA915761B (en) 1992-04-29
HUT59122A (en) 1992-04-28
MX9100343A (es) 1992-02-28
JPH04234380A (ja) 1992-08-24
IE912594A1 (en) 1992-01-29
IL98916A0 (en) 1992-07-15

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