Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3776961A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
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Filing date
Publication date
Application filed by Schering AGfiledCriticalSchering AG
Publication of GB971917ApublicationCriticalpatent/GB971917A/en
The invention comprises aminoindanes of formula <FORM:0971917/C1/1> where R1 is hydrogen or acyl, R2 is hydrogen, free hydroxyl or esterified hydroxyl, n is 0 or 1 and Am is an amino group disubstituted by alkyl groups which may themselves be substituted by hydroxyl groups or the amino group may form part of a heterocyclic ring. The compounds are prepared from compounds of formula <FORM:0971917/C1/2> where X is an alkyl, aryl or aralkyl radical and Y is hydrogen, which are reacted, e.g. by boiling with mineral acids, heating with pyridine hydrochloride or by catalytic hydrogenolysis, to replace X by hydrogen and Y, when it is not hydrogen, by hydroxyl. The phenolic hydroxyl groups may be esterified with monocarboxylic acids. Salts may be formed with bases and with compounds having free phenolic OH groups; salts also may be formed with the nitrogen atom of the amino group and acids. Examples are given. The compounds of Formula I produce spasmolytic effects upon the gastrointestinal tract and have local anaesthetic effects. The compounds, or their salts may be used as solutions and may be mixed with sodium dexamethasone sulphate or with basic theophyllin preparations.
GB3776961A1960-11-081961-10-20New aminoindanes and a process for their manufacture
ExpiredGB971917A
(en)
Procedure for the preparation of new derivatives of d treo - 1 - phenyl - 2 - amino - 1,3 - propandiol. (Machine-translation by Google Translate, not legally binding)