SE7710337L - PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS - Google Patents

PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS

Info

Publication number
SE7710337L
SE7710337L SE7710337A SE7710337A SE7710337L SE 7710337 L SE7710337 L SE 7710337L SE 7710337 A SE7710337 A SE 7710337A SE 7710337 A SE7710337 A SE 7710337A SE 7710337 L SE7710337 L SE 7710337L
Authority
SE
Sweden
Prior art keywords
steroids
halogenerated
procedure
preparation
chloro
Prior art date
Application number
SE7710337A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
M Biollaz
J Kalvoda
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7710337L publication Critical patent/SE7710337L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

9.alpha.-Chloro-11.beta.-fluoro-steroids are prepared according to a novel process by reacting a corresponding 9.alpha.-chloro-11.beta.-hydroxy-steroid with an aminosulphur trifluoride of the formula F3SX, in which X is an amino group derived from a secondary amine, especially diethylamine or piperidine. Any hydroxyl groups and carboxyl groups which may be present are preferably temporarily protected during the reaction.
SE7710337A 1976-09-16 1977-09-15 PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS SE7710337L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75809A LU75809A1 (en) 1976-09-16 1976-09-16

Publications (1)

Publication Number Publication Date
SE7710337L true SE7710337L (en) 1978-03-17

Family

ID=19728351

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7710337A SE7710337L (en) 1976-09-16 1977-09-15 PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS

Country Status (13)

Country Link
JP (1) JPS5337652A (en)
AT (1) AT356303B (en)
AU (1) AU514425B2 (en)
BE (1) BE858709A (en)
CA (1) CA1105003A (en)
DE (1) DE2741067A1 (en)
DK (1) DK410077A (en)
FR (1) FR2364928A1 (en)
GB (1) GB1584826A (en)
LU (1) LU75809A1 (en)
NL (1) NL7710086A (en)
SE (1) SE7710337L (en)
ZA (1) ZA775537B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029924B1 (en) 1979-11-16 1984-08-15 STEROSYNT Ltd. 6-alpha-fluoro-16-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them
IT1209140B (en) * 1979-11-16 1989-07-10 Prochem Ets 6 ALFA-FLUORO-PREDNISOLONE 17,21-DIESTERI.

Also Published As

Publication number Publication date
FR2364928B1 (en) 1981-03-06
AU514425B2 (en) 1981-02-12
DE2741067A1 (en) 1978-03-23
BE858709A (en) 1978-03-15
LU75809A1 (en) 1978-05-12
NL7710086A (en) 1978-03-20
CA1105003A (en) 1981-07-14
ATA663077A (en) 1979-09-15
ZA775537B (en) 1978-07-26
JPS5337652A (en) 1978-04-06
AT356303B (en) 1980-04-25
FR2364928A1 (en) 1978-04-14
DK410077A (en) 1978-03-17
AU2884877A (en) 1979-03-22
GB1584826A (en) 1981-02-18

Similar Documents

Publication Publication Date Title
ES8106539A1 (en) 17-alpha-substituted steroids, preparations containing them and process for their production.
GB1148570A (en) N,n'-diglycidyl compounds and process for their manufacture and use
NO149998C (en) ANALOGY PROCEDURE FOR PREPARING PEPTIDES WITH UBIQUIT-SIMILAR ACTIVITY.
SE7710337L (en) PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS
ES433049A1 (en) Novel 11{62 -alkyl steroids of the estrane series
FI51103C (en) Process for the preparation of anti-inflammatory pregnanoic acid derivatives.
ES413583A1 (en) N-2,4-dihydroxybenzoyl-4-aminosalicyclic acid
ES440046A1 (en) Derivatives of an antibiotic XK-62-2 and the process for the production thereof
ES417164A1 (en) Cardenolide-3-(2'-desoxy-glycosides)+0 and process for their manufacture
GB914525A (en) New n-substituted carbamic acid esters and a process for the production thereof
GB1092574A (en) 13,14-seco-steroids and process for their manufacture
ES467886A1 (en) 3 beta -Hydroxy-18 beta -olean-9-en-30-oic acids
ES284448A1 (en) Device for the protection of insulators against electrical arcs (Machine-translation by Google Translate, not legally binding)
JPS51138691A (en) Process for preparing novel b is-penicillins
IE40634B1 (en) Vinacmine 2-ketoglutarate and process for the production thereof
GB1487525A (en) Dermatological composition
ES387060A1 (en) Process for the manufacture of 21-fluorosteroids
CA528445A (en) Derivatives of 4:4'-diaminostilbene-disulfonic acid-(2:2') and process of making same
GB1289918A (en)
JPS5231031A (en) Process for preparation of substituted phosphonic acid derivatives
JPS51141893A (en) Process for preparing 9-substituted-2-cycloalkylthioadenines.
GB971917A (en) New aminoindanes and a process for their manufacture
ES444539A1 (en) Process for the preparation of 3,4,5-trimethoxy-phenyl-(1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridyl)-carbinol
JPS51131821A (en) Process for preparation of gamma-halo-delta-unsaturated carboxylic acids
ES271722A1 (en) New steroid compounds, and processes for their preparation

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 7710337-2

Format of ref document f/p: F