SE7710337L - PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS - Google Patents

PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS

Info

Publication number
SE7710337L
SE7710337L SE7710337A SE7710337A SE7710337L SE 7710337 L SE7710337 L SE 7710337L SE 7710337 A SE7710337 A SE 7710337A SE 7710337 A SE7710337 A SE 7710337A SE 7710337 L SE7710337 L SE 7710337L
Authority
SE
Sweden
Prior art keywords
steroids
halogenerated
procedure
preparation
chloro
Prior art date
Application number
SE7710337A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
M Biollaz
J Kalvoda
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7710337L publication Critical patent/SE7710337L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

9.alpha.-Chloro-11.beta.-fluoro-steroids are prepared according to a novel process by reacting a corresponding 9.alpha.-chloro-11.beta.-hydroxy-steroid with an aminosulphur trifluoride of the formula F3SX, in which X is an amino group derived from a secondary amine, especially diethylamine or piperidine. Any hydroxyl groups and carboxyl groups which may be present are preferably temporarily protected during the reaction.
SE7710337A 1976-09-16 1977-09-15 PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS SE7710337L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75809A LU75809A1 (en) 1976-09-16 1976-09-16

Publications (1)

Publication Number Publication Date
SE7710337L true SE7710337L (en) 1978-03-17

Family

ID=19728351

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7710337A SE7710337L (en) 1976-09-16 1977-09-15 PROCEDURE FOR THE PREPARATION OF 9,11-HALOGENERATED STEROIDS

Country Status (13)

Country Link
JP (1) JPS5337652A (en)
AT (1) AT356303B (en)
AU (1) AU514425B2 (en)
BE (1) BE858709A (en)
CA (1) CA1105003A (en)
DE (1) DE2741067A1 (en)
DK (1) DK410077A (en)
FR (1) FR2364928A1 (en)
GB (1) GB1584826A (en)
LU (1) LU75809A1 (en)
NL (1) NL7710086A (en)
SE (1) SE7710337L (en)
ZA (1) ZA775537B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209140B (en) * 1979-11-16 1989-07-10 Prochem Ets 6 ALFA-FLUORO-PREDNISOLONE 17,21-DIESTERI.
DE3069074D1 (en) * 1979-11-16 1984-10-04 Sterosynt Ltd 6-alpha-9-alpha-difluoro-16-beta-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA1105003A (en) 1981-07-14
BE858709A (en) 1978-03-15
JPS5337652A (en) 1978-04-06
FR2364928B1 (en) 1981-03-06
ATA663077A (en) 1979-09-15
FR2364928A1 (en) 1978-04-14
AT356303B (en) 1980-04-25
ZA775537B (en) 1978-07-26
AU2884877A (en) 1979-03-22
AU514425B2 (en) 1981-02-12
GB1584826A (en) 1981-02-18
LU75809A1 (en) 1978-05-12
DK410077A (en) 1978-03-17
DE2741067A1 (en) 1978-03-23
NL7710086A (en) 1978-03-20

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