ES450995A1 - 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof - Google Patents

4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof

Info

Publication number
ES450995A1
ES450995A1 ES450995A ES450995A ES450995A1 ES 450995 A1 ES450995 A1 ES 450995A1 ES 450995 A ES450995 A ES 450995A ES 450995 A ES450995 A ES 450995A ES 450995 A1 ES450995 A1 ES 450995A1
Authority
ES
Spain
Prior art keywords
amino
formula
quinoline derivatives
preparation
therapeutic applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES450995A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serdex
Original Assignee
Serdex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serdex filed Critical Serdex
Publication of ES450995A1 publication Critical patent/ES450995A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining new amino-4- quinoline derivatives, of general formula; ** (See formula) ** in which R is a straight or branched chain alkyl group having at least 10 carbon atoms, and and R2, the same or different, are each hydrogen, a halogen, an alkyl, aryl, hydroxy group, ether, thioether, amino, alkylamino, nitro or trifluoromethyl, as well as their salts are added with acids, characterized by the fact of reacting a quinoline of formula: ** (See formula) ** in which R1 and R2 have the aforementioned meanings and X is a nucleophobic grouping, with a primary amine NH2R, where R has the aforementioned significance, and the compound obtained is optionally salified by means of an acid. (Machine-translation by Google Translate, not legally binding)
ES450995A 1975-08-18 1976-08-17 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof Expired ES450995A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3424375A GB1496371A (en) 1975-08-18 1975-08-18 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof

Publications (1)

Publication Number Publication Date
ES450995A1 true ES450995A1 (en) 1977-09-01

Family

ID=10363223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES450995A Expired ES450995A1 (en) 1975-08-18 1976-08-17 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof

Country Status (4)

Country Link
BE (1) BE845271A (en)
ES (1) ES450995A1 (en)
FR (1) FR2321291A1 (en)
GB (1) GB1496371A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3644825A1 (en) * 1986-12-31 1988-07-14 Basf Ag SUBSTITUTED 1,8-NAPHTHYRIDINE DERIVATIVES AND FUNGICIDES CONTAINING THEM
IL89028A0 (en) * 1988-01-29 1989-08-15 Lilly Co Eli Quinoline,quinazoline and cinnoline derivatives
IL89029A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
EP0597003A1 (en) * 1991-08-02 1994-05-18 Pfizer Inc. Quinoline derivatives as immunostimulants
ATE202562T1 (en) * 1995-05-09 2001-07-15 Basf Ag (HET)ARYLOXY-, -THIO-, AMINOCROTONATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING ANIMAL PESTS AND HARMFUL FUNGI
ES2201674T3 (en) * 1998-01-26 2004-03-16 Smithkline Beecham Plc DERIVATIVES OF QUINOLINA WITH ANTIBACTERIAL PROPERTIES.
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) * 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US20060074105A1 (en) * 2004-09-20 2006-04-06 Serenex, Inc. Substituted quinoline and quinazoline inhibitors of quinone reductase 2
WO2011036557A1 (en) * 2009-09-22 2011-03-31 The University Of British Columbia Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles
EP3632426A1 (en) 2013-02-01 2020-04-08 Wellstat Therapeutics Corporation Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH58A (en) * 1889-01-08 F Bachschmid Innovation in anchor escapements
CH72A (en) * 1889-01-17 G Jun Meguin New to combing machines
CH84A (en) * 1889-01-10 Fontainemelon Horlogerie Improvement in the construction of winding mechanisms for watches of all calibers
CH49A (en) * 1889-01-16 Allemand H E System of cannon-olives with inner rivet

Also Published As

Publication number Publication date
FR2321291B1 (en) 1978-12-22
FR2321291A1 (en) 1977-03-18
GB1496371A (en) 1977-12-30
BE845271A (en) 1977-02-18

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