DE3827868A1 - Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel - Google Patents

Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel

Info

Publication number
DE3827868A1
DE3827868A1 DE3827868A DE3827868A DE3827868A1 DE 3827868 A1 DE3827868 A1 DE 3827868A1 DE 3827868 A DE3827868 A DE 3827868A DE 3827868 A DE3827868 A DE 3827868A DE 3827868 A1 DE3827868 A1 DE 3827868A1
Authority
DE
Germany
Prior art keywords
mersacidin
compound
culture
formula
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3827868A
Other languages
German (de)
English (en)
Inventor
Sukumar Dr Chatterjee
Sugata Dr Chatterjee
Bimal Naresh Dr Ganguli
Deepak Kumar Dr Chatterjee
Rajendra Kumar Hariprasad Jani
Richard Helmut Dr Rupp
Hans-Wolfram Dr Fehlhaber
Herbert Dr Kogler
Gerhard Prof Dr Seibert
Volker Dr Teetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IN193/BOM/88A priority Critical patent/IN167138B/en
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE3827868A priority patent/DE3827868A1/de
Priority to ES89114990T priority patent/ES2064398T3/es
Priority to DE58908558T priority patent/DE58908558D1/de
Priority to EP89114990A priority patent/EP0362520B1/de
Priority to AT89114990T priority patent/ATE113296T1/de
Priority to NZ230303A priority patent/NZ230303A/en
Priority to US07/393,953 priority patent/US5112806A/en
Priority to IL91317A priority patent/IL91317A0/xx
Priority to PH39098A priority patent/PH27179A/en
Priority to FI893842A priority patent/FI94648C/fi
Priority to CA000608500A priority patent/CA1338171C/en
Priority to AU39966/89A priority patent/AU613228B2/en
Priority to JP1210228A priority patent/JP2892699B2/ja
Priority to HU894215A priority patent/HU203906B/hu
Priority to ZA896245A priority patent/ZA896245B/xx
Priority to NO893288A priority patent/NO174517B/no
Priority to IE263889A priority patent/IE64706B1/en
Priority to DK198904037A priority patent/DK175121B1/da
Priority to KR1019890011679A priority patent/KR0139628B1/ko
Priority to PT91468A priority patent/PT91468B/pt
Publication of DE3827868A1 publication Critical patent/DE3827868A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
DE3827868A 1988-08-17 1988-08-17 Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel Withdrawn DE3827868A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IN193/BOM/88A IN167138B (fi) 1988-08-17 1988-07-04
DE3827868A DE3827868A1 (de) 1988-08-17 1988-08-17 Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel
ES89114990T ES2064398T3 (es) 1988-08-17 1989-08-14 Un nuevo antibiotico, mersacidina, un procedimiento para su preparacion y su utilizacion como medicamento.
DE58908558T DE58908558D1 (de) 1988-08-17 1989-08-14 Ein neues Antibiotikum, Mersacidin, ein Verfahren zur seiner Herstellung und seine Verwendung als Arzneimittel.
EP89114990A EP0362520B1 (de) 1988-08-17 1989-08-14 Ein neues Antibiotikum, Mersacidin, ein Verfahren zur seiner Herstellung und seine Verwendung als Arzneimittel
AT89114990T ATE113296T1 (de) 1988-08-17 1989-08-14 Ein neues antibiotikum, mersacidin, ein verfahren zur seiner herstellung und seine verwendung als arzneimittel.
NZ230303A NZ230303A (en) 1988-08-17 1989-08-15 "mersacidin", its preparation, and its pharmaceutical compositions
US07/393,953 US5112806A (en) 1988-08-17 1989-08-15 Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical
IL91317A IL91317A0 (en) 1988-08-17 1989-08-15 New antibiotic,mersacidin,a process for the preparation thereof and the use thereof as a pharmaceutical
PH39098A PH27179A (en) 1988-08-17 1989-08-15 A new antibiotic mersacidin pharmaceutical composition containing said compound and method of use thereof
FI893842A FI94648C (fi) 1988-08-17 1989-08-15 Menetelmä uuden antibiootin, mersasidiinin, valmistamiseksi
CA000608500A CA1338171C (en) 1988-08-17 1989-08-16 Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical
AU39966/89A AU613228B2 (en) 1988-08-17 1989-08-16 A new antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical
JP1210228A JP2892699B2 (ja) 1988-08-17 1989-08-16 新規な抗生物質メルサシジンおよびその製法
HU894215A HU203906B (en) 1988-08-17 1989-08-16 Process for producing new antibioticum named mersacidin and salts and pharmaceutical composition containing them as active components
ZA896245A ZA896245B (en) 1988-08-17 1989-08-16 A new antibiotic,mersacidin,a process for the preparation thereof and the use thereof as a pharmaceutical
NO893288A NO174517B (no) 1988-08-17 1989-08-16 Fremgangsmaate for fremstilling av et nytt antibiotikum, Mersacidin
IE263889A IE64706B1 (en) 1988-08-17 1989-08-16 A new antibiotic mersacidin a process for the preparation thereof and the use thereof as a pharmaceutical
DK198904037A DK175121B1 (da) 1988-08-17 1989-08-16 Mersacidin og dennes forbindelses fysiologisk tålelige salte, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende forbindelsen, dens anvendelse til fremstilling af lægemidler med antibiotisk virkning samt Bacillus specis Y-85,54728 (DSM 4584)
KR1019890011679A KR0139628B1 (ko) 1988-08-17 1989-08-17 항생물질 머사시딘, 이의 제조방법 및 이를 함유하는 약제
PT91468A PT91468B (pt) 1988-08-17 1989-08-17 Processo para a preparacao de um novo antibiotico mersacidina e de composicoes farmaceuticas que o contem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3827868A DE3827868A1 (de) 1988-08-17 1988-08-17 Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DE3827868A1 true DE3827868A1 (de) 1990-02-22

Family

ID=6361001

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3827868A Withdrawn DE3827868A1 (de) 1988-08-17 1988-08-17 Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel
DE58908558T Expired - Lifetime DE58908558D1 (de) 1988-08-17 1989-08-14 Ein neues Antibiotikum, Mersacidin, ein Verfahren zur seiner Herstellung und seine Verwendung als Arzneimittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE58908558T Expired - Lifetime DE58908558D1 (de) 1988-08-17 1989-08-14 Ein neues Antibiotikum, Mersacidin, ein Verfahren zur seiner Herstellung und seine Verwendung als Arzneimittel.

Country Status (20)

Country Link
US (1) US5112806A (fi)
EP (1) EP0362520B1 (fi)
JP (1) JP2892699B2 (fi)
KR (1) KR0139628B1 (fi)
AT (1) ATE113296T1 (fi)
AU (1) AU613228B2 (fi)
CA (1) CA1338171C (fi)
DE (2) DE3827868A1 (fi)
DK (1) DK175121B1 (fi)
ES (1) ES2064398T3 (fi)
FI (1) FI94648C (fi)
HU (1) HU203906B (fi)
IE (1) IE64706B1 (fi)
IL (1) IL91317A0 (fi)
IN (1) IN167138B (fi)
NO (1) NO174517B (fi)
NZ (1) NZ230303A (fi)
PH (1) PH27179A (fi)
PT (1) PT91468B (fi)
ZA (1) ZA896245B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0700998B1 (en) * 1994-09-12 2003-11-26 Aventis Pharma Deutschland GmbH Recombinant mersacidin and a method for production
US5910479A (en) * 1996-10-18 1999-06-08 Ambi Inc. Method for the treatment of Streptococcus pneumoniae infection
US6861236B2 (en) * 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
JP2009509519A (ja) * 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714030D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
CN102348718B (zh) 2009-01-14 2015-06-03 诺瓦克塔生物系统有限公司 去氧阿肽加定衍生物
EP2393829A1 (en) 2009-02-04 2011-12-14 Novacta Biosystems Limited Actagardine derivatives
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
KR102582570B1 (ko) * 2021-03-19 2023-09-22 한국생명공학연구원 유박테리움 칼란데리, 이의 배양액 또는 이의 배양액 추출물을 유효성분으로 포함하는 암 예방 또는 치료용 조성물
EP4404946A1 (en) * 2021-09-22 2024-07-31 BiomEdit, LLC Methods of inhibiting diseases caused by respiratory viruses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
JPS61134398A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 新生理活性物質プリパスタチン及びその製造法

Also Published As

Publication number Publication date
PT91468A (pt) 1990-03-08
US5112806A (en) 1992-05-12
DK403789A (da) 1990-02-18
FI893842A0 (fi) 1989-08-15
AU3996689A (en) 1990-02-22
IN167138B (fi) 1990-09-01
FI893842A (fi) 1990-02-18
DK175121B1 (da) 2004-06-07
NZ230303A (en) 1992-06-25
AU613228B2 (en) 1991-07-25
FI94648C (fi) 1995-10-10
ES2064398T3 (es) 1995-02-01
PT91468B (pt) 1995-05-04
NO893288L (no) 1990-02-19
ATE113296T1 (de) 1994-11-15
HU203906B (en) 1991-10-28
IE64706B1 (en) 1995-08-23
DE58908558D1 (de) 1994-12-01
EP0362520B1 (de) 1994-10-26
JPH02142800A (ja) 1990-05-31
ZA896245B (en) 1990-04-25
CA1338171C (en) 1996-03-19
PH27179A (en) 1993-04-02
EP0362520A2 (de) 1990-04-11
HUT55054A (en) 1991-04-29
IL91317A0 (en) 1990-03-19
EP0362520A3 (de) 1991-10-23
IE892638L (en) 1990-02-17
FI94648B (fi) 1995-06-30
DK403789D0 (da) 1989-08-16
NO174517C (fi) 1994-05-18
NO174517B (no) 1994-02-07
KR900003206A (ko) 1990-03-26
NO893288D0 (no) 1989-08-16
KR0139628B1 (ko) 1998-07-01
JP2892699B2 (ja) 1999-05-17

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