DE3783579D1 - Derivate des alpha-anp und ihre herstellung. - Google Patents
Derivate des alpha-anp und ihre herstellung.Info
- Publication number
- DE3783579D1 DE3783579D1 DE8787308586T DE3783579T DE3783579D1 DE 3783579 D1 DE3783579 D1 DE 3783579D1 DE 8787308586 T DE8787308586 T DE 8787308586T DE 3783579 T DE3783579 T DE 3783579T DE 3783579 D1 DE3783579 D1 DE 3783579D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- gly
- arg
- hydrogen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 229940126585 therapeutic drug Drugs 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- 125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical group OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229940124280 l-arginine Drugs 0.000 abstract 1
- 230000001452 natriuretic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- C07K14/582—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5231429A JPH0726436A (ja) | 1993-09-17 | 1993-09-17 | 人工芝用パイルおよびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3783579D1 true DE3783579D1 (de) | 1993-02-25 |
| DE3783579T2 DE3783579T2 (de) | 1993-05-13 |
Family
ID=16923426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787308586T Expired - Fee Related DE3783579T2 (de) | 1993-09-17 | 1987-09-29 | Derivate des alpha-anp und ihre herstellung. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5159061A (de) |
| EP (1) | EP0269220B1 (de) |
| JP (2) | JP2508755B2 (de) |
| AT (1) | ATE84545T1 (de) |
| CA (1) | CA1339678C (de) |
| DE (1) | DE3783579T2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0246795A3 (de) * | 1986-05-20 | 1990-04-04 | Advanced Peptide Development Limited | Synthetische natriuretische Peptide |
| DE3723551A1 (de) * | 1987-07-16 | 1989-01-26 | Hoechst Ag | Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| JP2855143B2 (ja) * | 1987-12-24 | 1999-02-10 | サイオス インコーポレイテッド | 心房の，ナトリウム排出亢進性ペプチドの直鎖アナログ |
| US5047397A (en) * | 1988-08-26 | 1991-09-10 | California Biotechnology Inc. | Linear analogs of atrial natriuretic peptides |
| JP2873586B2 (ja) * | 1988-07-15 | 1999-03-24 | 武田薬品工業株式会社 | 抗体およびこれを用いる免疫化学的測定方法 |
| JPH04504552A (ja) * | 1988-11-03 | 1992-08-13 | プライム・テクノロジー・インコーポレーテッド | 給紙装置 |
| JPH06256387A (ja) * | 1991-06-14 | 1994-09-13 | Suetsuna Yoko | 新規なペプチド、その製法およびそれを有効成分とする 血圧降下剤 |
| US6525022B1 (en) | 1993-11-12 | 2003-02-25 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US5665704A (en) * | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US5846932A (en) * | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| WO2007115175A2 (en) | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| US7795221B2 (en) * | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5178029A (de) * | 1974-12-27 | 1976-07-07 | Mitsubishi Rayon Co | |
| JPS5421477A (en) * | 1977-07-20 | 1979-02-17 | Nitto Boseki Co Ltd | Rotating disc of reinforced plastic |
| JPS5841955A (ja) * | 1981-08-31 | 1983-03-11 | 関島 唯雄 | 水引用巻着フイルムの製造方法 |
| AU572173B2 (en) * | 1983-08-29 | 1988-05-05 | Institut De Recherches Cliniques De Montreal | Natriuretic factors |
| US4508712A (en) * | 1984-01-10 | 1985-04-02 | Washington University | Atrial peptide |
| EP0180615B1 (de) * | 1984-04-19 | 1995-04-05 | Scios Nova Inc. | Atrielle natriumuretische/gefässerweiterende polypeptide |
| JPS60259646A (ja) * | 1984-06-01 | 1985-12-21 | 帝人株式会社 | 嵩高混繊糸 |
| AU600652B2 (en) * | 1984-06-08 | 1990-08-23 | Hisayuki Matsuo | Human atrial natriuretic peptide and gene encoding same |
| JPS617260U (ja) * | 1984-06-19 | 1986-01-17 | 国産電機株式会社 | 電動機 |
| JPS61233698A (ja) * | 1985-04-09 | 1986-10-17 | Ajinomoto Co Inc | 新規ペプチド |
| JPH0672157B2 (ja) * | 1984-08-29 | 1994-09-14 | 味の素株式会社 | 新規ペプチド |
| JPS61286400A (ja) * | 1985-06-14 | 1986-12-16 | Ajinomoto Co Inc | 新規ペプチド |
| US4670540A (en) * | 1984-08-29 | 1987-06-02 | Ajinomoto Co., Inc. | Novel peptide |
| DE3443257A1 (de) * | 1984-11-28 | 1986-05-28 | Bissendorf Peptide GmbH, 3002 Wedemark | Mittel enthaltend vollsynthetisches alpha-humanes atriales natriuretisches peptid (alpha-hanap) |
| JPS61161299A (ja) * | 1985-01-04 | 1986-07-21 | メルク エンド カムパニ− インコ−ポレ−テツド | 心房ペプチド |
| JPS61280400A (ja) * | 1985-06-04 | 1986-12-10 | 三菱電機株式会社 | アクテイブ近接信管 |
| IE862891L (en) * | 1985-11-05 | 1987-05-05 | Behringwerke Ag | Analogs of atrial natriuretic peptides |
| US4757048A (en) * | 1985-11-05 | 1988-07-12 | Biotechnology Research Associates J.V. | Synthetic analogs of atrial natriuretic peptides |
| DE3614833A1 (de) * | 1986-01-16 | 1987-07-23 | Hoechst Ag | Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| EP0232078A3 (de) * | 1986-01-31 | 1990-03-14 | Merck & Co. Inc. | Peptide mit ANF-Wirkung |
| EP0246795A3 (de) * | 1986-05-20 | 1990-04-04 | Advanced Peptide Development Limited | Synthetische natriuretische Peptide |
-
1987
- 1987-09-25 US US07/101,199 patent/US5159061A/en not_active Expired - Fee Related
- 1987-09-25 CA CA000547893A patent/CA1339678C/en not_active Expired - Fee Related
- 1987-09-28 JP JP62244885A patent/JP2508755B2/ja not_active Expired - Fee Related
- 1987-09-29 EP EP87308586A patent/EP0269220B1/de not_active Expired - Lifetime
- 1987-09-29 AT AT87308586T patent/ATE84545T1/de not_active IP Right Cessation
- 1987-09-29 DE DE8787308586T patent/DE3783579T2/de not_active Expired - Fee Related
-
1993
- 1993-09-17 JP JP5231429A patent/JPH0726436A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0269220B1 (de) | 1993-01-13 |
| JP2508755B2 (ja) | 1996-06-19 |
| DE3783579T2 (de) | 1993-05-13 |
| EP0269220A3 (en) | 1990-05-23 |
| JPH0726436A (ja) | 1995-01-27 |
| CA1339678C (en) | 1998-02-17 |
| JPS63179891A (ja) | 1988-07-23 |
| EP0269220A2 (de) | 1988-06-01 |
| ATE84545T1 (de) | 1993-01-15 |
| US5159061A (en) | 1992-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |