DE3768533D1 - Verfahren zur massenanalyse einer probe. - Google Patents

Verfahren zur massenanalyse einer probe.

Info

Publication number
DE3768533D1
DE3768533D1 DE8787301907T DE3768533T DE3768533D1 DE 3768533 D1 DE3768533 D1 DE 3768533D1 DE 8787301907 T DE8787301907 T DE 8787301907T DE 3768533 T DE3768533 T DE 3768533T DE 3768533 D1 DE3768533 D1 DE 3768533D1
Authority
DE
Germany
Prior art keywords
sample
mass analysis
analysis
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787301907T
Other languages
English (en)
Inventor
Jr George C Stafford
Dennis M Taylor
Stephen C Bradshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Finnigan LLC
Original Assignee
Finnigan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25275181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3768533(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Finnigan Corp filed Critical Finnigan Corp
Application granted granted Critical
Publication of DE3768533D1 publication Critical patent/DE3768533D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/4265—Controlling the number of trapped ions; preventing space charge effects
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/429—Scanning an electric parameter, e.g. voltage amplitude or frequency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE8787301907T 1986-03-07 1987-03-05 Verfahren zur massenanalyse einer probe. Expired - Fee Related DE3768533D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,702 US5107109A (en) 1986-03-07 1986-03-07 Method of increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer

Publications (1)

Publication Number Publication Date
DE3768533D1 true DE3768533D1 (de) 1991-04-18

Family

ID=25275181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787301907T Expired - Fee Related DE3768533D1 (de) 1986-03-07 1987-03-05 Verfahren zur massenanalyse einer probe.

Country Status (5)

Country Link
US (1) US5107109A (de)
EP (1) EP0237268B1 (de)
JP (1) JP2779158B2 (de)
CA (1) CA1248642A (de)
DE (1) DE3768533D1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206507A (en) * 1991-02-28 1993-04-27 Teledyne Mec Mass spectrometry method using filtered noise signal
US5200613A (en) * 1991-02-28 1993-04-06 Teledyne Mec Mass spectrometry method using supplemental AC voltage signals
US5272337A (en) * 1992-04-08 1993-12-21 Martin Marietta Energy Systems, Inc. Sample introducing apparatus and sample modules for mass spectrometer
US5479012A (en) * 1992-05-29 1995-12-26 Varian Associates, Inc. Method of space charge control in an ion trap mass spectrometer
US5397894A (en) * 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
US5324939A (en) * 1993-05-28 1994-06-28 Finnigan Corporation Method and apparatus for ejecting unwanted ions in an ion trap mass spectrometer
DE4326549C1 (de) * 1993-08-07 1994-08-25 Bruker Franzen Analytik Gmbh Verfahren für eine Regelung der Raumladung in Ionenfallen
DE19501823A1 (de) * 1995-01-21 1996-07-25 Bruker Franzen Analytik Gmbh Verfahren zur Regelung der Erzeugungsraten für massenselektives Einspeichern von Ionen in Ionenfallen
DE19501835C2 (de) * 1995-01-21 1998-07-02 Bruker Franzen Analytik Gmbh Verfahren zur Anregung der Schwingungen von Ionen in Ionenfallen mit Frequenzgemischen
US5572022A (en) * 1995-03-03 1996-11-05 Finnigan Corporation Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer
JP3294106B2 (ja) * 1996-05-21 2002-06-24 株式会社日立製作所 三次元四重極質量分析法および装置
DE19709086B4 (de) * 1997-03-06 2007-03-15 Bruker Daltonik Gmbh Verfahren der Raumladungsregelung von Tochterionen in Ionenfallen
DE19709172B4 (de) * 1997-03-06 2007-03-22 Bruker Daltonik Gmbh Verfahren der vergleichenden Analyse mit Ionenfallenmassenspektrometern
US6147348A (en) * 1997-04-11 2000-11-14 University Of Florida Method for performing a scan function on quadrupole ion trap mass spectrometers
US6080985A (en) * 1997-09-30 2000-06-27 The Perkin-Elmer Corporation Ion source and accelerator for improved dynamic range and mass selection in a time of flight mass spectrometer
JP3413079B2 (ja) * 1997-10-09 2003-06-03 株式会社日立製作所 イオントラップ型質量分析装置
US6091068A (en) * 1998-05-04 2000-07-18 Leybold Inficon, Inc. Ion collector assembly
US6255648B1 (en) * 1998-10-16 2001-07-03 Applied Automation, Inc. Programmed electron flux
US6239429B1 (en) 1998-10-26 2001-05-29 Mks Instruments, Inc. Quadrupole mass spectrometer assembly
DE19930894B4 (de) * 1999-07-05 2007-02-08 Bruker Daltonik Gmbh Verfahren zur Regelung der Ionenzahl in Ionenzyklotronresonanz-Massenspektrometern
JP2001160373A (ja) * 1999-12-02 2001-06-12 Hitachi Ltd イオントラップ質量分析方法並びにイオントラップ質量分析計
US6528784B1 (en) 1999-12-03 2003-03-04 Thermo Finnigan Llc Mass spectrometer system including a double ion guide interface and method of operation
US6387436B1 (en) 2000-03-31 2002-05-14 The Quaker Oats Company Granola-type food product and method
DE10027545C1 (de) 2000-06-02 2001-10-31 Bruker Daltonik Gmbh Regelung der Ionenfüllung in Ionenfallenmassenspektrometern
GB0029040D0 (en) * 2000-11-29 2001-01-10 Micromass Ltd Orthogonal time of flight mass spectrometer
US7038197B2 (en) * 2001-04-03 2006-05-02 Micromass Limited Mass spectrometer and method of mass spectrometry
US6777671B2 (en) * 2001-04-10 2004-08-17 Science & Engineering Services, Inc. Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
JP4303108B2 (ja) * 2001-08-30 2009-07-29 エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス リニアイオントラップ型質量分析計における空間電荷低減方法
US20040119014A1 (en) * 2002-12-18 2004-06-24 Alex Mordehai Ion trap mass spectrometer and method for analyzing ions
US6884996B2 (en) * 2003-06-04 2005-04-26 Thermo Finnigan Llc Space charge adjustment of activation frequency
DE102004001514A1 (de) * 2004-01-09 2005-08-04 Marcus Dr.-Ing. Gohl Verfahren und Vorrichtung zur Bestimmung des Schmierölgehalts in einem Abgasgemisch
GB2412487A (en) * 2004-03-26 2005-09-28 Thermo Finnigan Llc A method of improving a mass spectrum
WO2006002027A2 (en) 2004-06-15 2006-01-05 Griffin Analytical Technologies, Inc. Portable mass spectrometer configured to perform multidimensional mass analysis
US7323682B2 (en) * 2004-07-02 2008-01-29 Thermo Finnigan Llc Pulsed ion source for quadrupole mass spectrometer and method
JP4644506B2 (ja) * 2005-03-28 2011-03-02 株式会社日立ハイテクノロジーズ 質量分析装置
US7535329B2 (en) * 2005-04-14 2009-05-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
US20060232369A1 (en) * 2005-04-14 2006-10-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
WO2006116564A2 (en) * 2005-04-25 2006-11-02 Griffin Analytical Technologies, L.L.C. Analytical instrumentation, appartuses, and methods
US7291845B2 (en) * 2005-04-26 2007-11-06 Varian, Inc. Method for controlling space charge-driven ion instabilities in electron impact ion sources
GB0511083D0 (en) * 2005-05-31 2005-07-06 Thermo Finnigan Llc Multiple ion injection in mass spectrometry
US7992424B1 (en) 2006-09-14 2011-08-09 Griffin Analytical Technologies, L.L.C. Analytical instrumentation and sample analysis methods
US20080210860A1 (en) * 2007-03-02 2008-09-04 Kovtoun Viatcheslav V Segmented ion trap mass spectrometry
US7977626B2 (en) * 2007-06-01 2011-07-12 Agilent Technologies, Inc. Time of flight mass spectrometry method and apparatus
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
US7982181B1 (en) 2008-01-15 2011-07-19 Thermo Finnigan Llc Methods for identifying an apex for improved data-dependent acquisition
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
GB2511582B (en) 2011-05-20 2016-02-10 Thermo Fisher Scient Bremen Method and apparatus for mass analysis
WO2014164198A1 (en) 2013-03-11 2014-10-09 David Rafferty Automatic gain control with defocusing lens
US9202681B2 (en) 2013-04-12 2015-12-01 Thermo Finnigan Llc Methods for predictive automatic gain control for hybrid mass spectrometers
US9165755B2 (en) 2013-06-07 2015-10-20 Thermo Finnigan Llc Methods for predictive automatic gain control for hybrid mass spectrometers
US20140374583A1 (en) * 2013-06-24 2014-12-25 Agilent Technologies, Inc. Electron ionization (ei) utilizing different ei energies
DE102013213501A1 (de) 2013-07-10 2015-01-15 Carl Zeiss Microscopy Gmbh Massenspektrometer, dessen Verwendung, sowie Verfahren zur massenspektrometrischen Untersuchung eines Gasgemisches
US10176977B2 (en) 2014-12-12 2019-01-08 Agilent Technologies, Inc. Ion source for soft electron ionization and related systems and methods
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
EP3321953B1 (de) 2016-11-10 2019-06-26 Thermo Finnigan LLC Systeme und verfahren zur skalierung einer injektion-wellenformsamplitude während der ionenisolation
WO2018134346A1 (en) 2017-01-19 2018-07-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Mass spectrometry with improved dynamic range
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
US10128099B1 (en) 2017-07-20 2018-11-13 Thermo Finnigan Llc Systems and methods for regulating the ion population in an ion trap for MSn scans
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
WO2019030475A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov MASS SPECTROMETER WITH MULTIPASSAGE
WO2019030471A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ION GUIDE INSIDE PULSED CONVERTERS
US11205568B2 (en) 2017-08-06 2021-12-21 Micromass Uk Limited Ion injection into multi-pass mass spectrometers
WO2019030472A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov IONIC MIRROR FOR MULTI-REFLECTION MASS SPECTROMETERS
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
WO2019030473A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov FIELDS FOR SMART REFLECTIVE TOF SM
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
GB201906546D0 (en) 2019-05-09 2019-06-26 Thermo Fisher Scient Bremen Gmbh Charge detection for ion current control
GB2584125B (en) 2019-05-22 2021-11-03 Thermo Fisher Scient Bremen Gmbh Dynamic control of accumulation time for chromatography mass spectrometry
US20240071742A1 (en) * 2022-08-25 2024-02-29 Thermo Finnigan Llc Two frequency ion trap performance

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535512A (en) * 1966-07-21 1970-10-20 Varian Associates Double resonance ion cyclotron mass spectrometer for studying ion-molecule reactions
US3937955A (en) * 1974-10-15 1976-02-10 Nicolet Technology Corporation Fourier transform ion cyclotron resonance spectroscopy method and apparatus
US4105917A (en) * 1976-03-26 1978-08-08 The Regents Of The University Of California Method and apparatus for mass spectrometric analysis at ultra-low pressures
DE3124465C2 (de) * 1981-06-22 1985-02-14 Spectrospin AG, Fällanden, Zürich Verfahren zur Ionen-Zyklotron-Resonanz-Spektroskopie
US4540884A (en) * 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US4535235A (en) * 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
JPS62168327A (ja) * 1985-12-17 1987-07-24 Shimadzu Corp パルスイオン化検出方法

Also Published As

Publication number Publication date
CA1248642A (en) 1989-01-10
JPS62276739A (ja) 1987-12-01
US5107109A (en) 1992-04-21
EP0237268A3 (en) 1988-08-24
EP0237268A2 (de) 1987-09-16
EP0237268B1 (de) 1991-03-13
JP2779158B2 (ja) 1998-07-23

Similar Documents

Publication Publication Date Title
DE3768533D1 (de) Verfahren zur massenanalyse einer probe.
DE3578824D1 (de) Verfahren und vorrichtung zur untersuchung der oberflaechenbedingungen einer probe.
DE3854056T2 (de) Verfahren zum Nachweis einer Nukleinsäure-Sequenz in einer Probe.
DE3679535D1 (de) Analytisches geraet und verfahren zur bestimmung der konzentration einer probekomponente.
DE3864467D1 (de) Geraet und verfahren zur messung von deformationen einer probe.
DE68929385T2 (de) Verfahren zur Bestimmung eines Analyten unter Verwendung einer replizierbare RNS enthaltenden Sonde
DE3772100D1 (de) Verfahren und geraet zur bestimmung einer spezies in einer probe.
DE69529462D1 (de) Verfahren zur auswahl einer population oder subpopulation einer probe
DE69010410D1 (de) Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung.
DE68907407T2 (de) Verfahren zur sequenzanalyse von dna.
DE69026263D1 (de) Verfahren zur aufbereitung einer zu analysierenden probe
DE3751414D1 (de) Vorrichtung zur Entnahme einer Probe für mikrobiologische Zwecke.
DE3853254T2 (de) Ausrüstungssatz und Verfahren für Analysen von biologischen Proben.
ATA356685A (de) Verfahren zur quantitativen messung von kohlenwasserstoffen
DE69024810T2 (de) Verfahren zur vorbereitung einer probe für analyse
DE69022240D1 (de) Verfahren zur vorbereitung einer probe für analyse.
DE3863708D1 (de) Geraet und verfahren zur messung von deformationen einer probe.
ATA25586A (de) Verfahren zur optischen bestimmung der katalytischen enzymaktivitaet einer probe, und eine anordnung zur durchfuehrung des verfahrens
DE3789310D1 (de) Verfahren zur feststellung der entwicklungsgeschichte eines körperzustandes aus einer einzigen blutprobe.
DE58904104D1 (de) Verfahren zur identifizierung des ursprungs einer zell- oder gewebsprobe.
DE69017104T2 (de) Verfahren und Vorrichtung zur Prüfung einer Lambda-Sonde.
DE3769599D1 (de) Verfahren zum analysieren einer haemolysierten blutprobe.
DE69000071D1 (de) Vorrichtung zur dynamischen torsionspruefung einer probe.
DE209900T1 (de) Verfahren und vorrichtung zur messung des erweichungspunktes einer glasigen probe.
DE69025135D1 (de) Verfahren zur Analyse von Catecholamin

Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: FINNIGAN CORP. (N.D.GES. D. STAATES DELAWARE), SAN

8328 Change in the person/name/address of the agent

Free format text: PATENT- UND RECHTSANWAELTE BARDEHLE, PAGENBERG, DOST, ALTENBURG, GEISSLER, ISENBRUCK, 81679 MUENCHEN

8310 Action for declaration of annulment
8313 Request for invalidation rejected/withdrawn
8327 Change in the person/name/address of the patent owner

Owner name: THERMO FINNIGAN LLC, WILMINGTON, DEL., US

8339 Ceased/non-payment of the annual fee