DE69010410D1 - Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung. - Google Patents

Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung.

Info

Publication number
DE69010410D1
DE69010410D1 DE69010410T DE69010410T DE69010410D1 DE 69010410 D1 DE69010410 D1 DE 69010410D1 DE 69010410 T DE69010410 T DE 69010410T DE 69010410 T DE69010410 T DE 69010410T DE 69010410 D1 DE69010410 D1 DE 69010410D1
Authority
DE
Germany
Prior art keywords
desorption
mass analysis
frozen solution
preparing samples
samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69010410T
Other languages
English (en)
Other versions
DE69010410T2 (de
Inventor
Christopher Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Application granted granted Critical
Publication of DE69010410D1 publication Critical patent/DE69010410D1/de
Publication of DE69010410T2 publication Critical patent/DE69010410T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE69010410T 1989-01-17 1990-01-12 Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung. Expired - Lifetime DE69010410T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/298,649 US4920264A (en) 1989-01-17 1989-01-17 Method for preparing samples for mass analysis by desorption from a frozen solution
PCT/US1990/000229 WO1990008398A1 (en) 1989-01-17 1990-01-12 A method of preparing samples for mass analysis by desorption from a frozen solution

Publications (2)

Publication Number Publication Date
DE69010410D1 true DE69010410D1 (de) 1994-08-11
DE69010410T2 DE69010410T2 (de) 1994-10-20

Family

ID=23151435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69010410T Expired - Lifetime DE69010410T2 (de) 1989-01-17 1990-01-12 Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung.

Country Status (6)

Country Link
US (1) US4920264A (de)
EP (1) EP0404934B1 (de)
JP (1) JP3057607B2 (de)
CA (1) CA2025771A1 (de)
DE (1) DE69010410T2 (de)
WO (1) WO1990008398A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
GB2235529B (en) * 1989-08-23 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
GB2235528B (en) * 1989-08-23 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
JP2564404B2 (ja) * 1989-09-20 1996-12-18 株式会社日立製作所 質量分析方法
US5135870A (en) * 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
DE4036115C2 (de) * 1990-11-13 1997-12-11 Max Planck Gesellschaft Verfahren und Einrichtung zur quantitativen nichtresonanten Photoionisation von Neutralteilchen und Verwendung einer solchen Einrichtung
US5210412A (en) * 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
WO1992013629A1 (en) * 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5208458A (en) * 1991-11-05 1993-05-04 Georgia Tech Research Corporation Interface device to couple gel electrophoresis with mass spectrometry using sample disruption
US5763875A (en) * 1991-11-12 1998-06-09 Max Planck Gesellschaft Method and apparatus for quantitative, non-resonant photoionization of neutral particles
US5171989A (en) * 1992-01-24 1992-12-15 Board Of Trustees Of Leland Stanford Jr. University Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
JPH05251408A (ja) * 1992-03-06 1993-09-28 Ebara Corp 半導体ウェーハのエッチング装置
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5360976A (en) * 1992-08-25 1994-11-01 Southwest Research Institute Time of flight mass spectrometer, ion source, and methods of preparing a sample for mass analysis and of mass analyzing a sample
US5397895A (en) * 1992-09-24 1995-03-14 The United States Of America As Represented By The Secretary Of Commerce Photoionization mass spectroscopy flux monitor
US6436635B1 (en) * 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
JPH08509857A (ja) 1993-01-07 1996-10-22 シーケノム・インコーポレーテッド マススペクトロメトリーによるｄｎａ配列決定法
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
US6653626B2 (en) 1994-07-11 2003-11-25 Agilent Technologies, Inc. Ion sampling for APPI mass spectrometry
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US20060063193A1 (en) * 1995-04-11 2006-03-23 Dong-Jing Fu Solid phase sequencing of double-stranded nucleic acids
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5589685A (en) * 1995-05-26 1996-12-31 Jen Wu; Kuang Matrix enhanced SIMS
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
EP0886681A1 (de) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Verfahren zur suche von nukleinsäuren mit massenspektroskopie
DE19617011C2 (de) * 1996-04-27 2000-11-02 Bruker Daltonik Gmbh Matrixkomponentengemisch für die matrixunterstützte Laserdesorption und Ionisierung sowie Verfahren zur Zubereitung eines Matrixkomponentengemisches
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US20030129589A1 (en) * 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
EP1457496B1 (de) 1996-11-06 2014-01-15 Sequenom, Inc. Immobilisierung mit hoher Dichte von Nukleinsäuren
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
US5854486A (en) * 1996-12-27 1998-12-29 R. T. Hodgson Method and apparatus for MALDI mass spectrometry
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
WO1998054751A1 (en) * 1997-05-30 1998-12-03 Genetrace Systems, Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6104028A (en) * 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
DE19934561C2 (de) * 1999-07-22 2001-12-13 Stiftung A Wegener Inst Polar Analyseverfahren zur Detektion von räumlichen Spurenelement-Verteilungsmustern in einer Feststoffprobe und Anordnung zu seiner Druchführung
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
WO2002054057A1 (de) * 2001-01-05 2002-07-11 Stiftung Alfred-Wegener-Institut Für Polar- Und Meeresforschung Analyseverfahren zur detektion von räumlichen spurenelement-verteilungsmustern und vorrichtung zur verfahrensdurchführung
WO2005050172A2 (en) * 2003-11-14 2005-06-02 Indiana University Research And Technology Corporation Methods and apparatus for mass spectral analysis of peptides and proteins
JP4366508B2 (ja) * 2004-03-30 2009-11-18 国立大学法人山梨大学 質量分析のためのイオン化方法および装置
US8642353B2 (en) 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
JP2008185547A (ja) * 2007-01-31 2008-08-14 Canon Inc 情報取得方法及び情報取得装置
DE102009018021B4 (de) 2009-04-18 2013-09-05 Helmholtz-Zentrum Berlin Für Materialien Und Energie Gmbh Mikrodosiersystem mit einem gepulsten Laser
JP4569788B1 (ja) * 2009-09-14 2010-10-27 京セラ株式会社 無線基地局及び通信制御方法
US10643828B2 (en) * 2015-09-18 2020-05-05 Baylor University High resolution imaging mass spectrometry
CA2937046A1 (en) * 2016-07-25 2018-01-25 Kresimir Franjic Method for preparing thin sample layers
US11035807B2 (en) * 2018-03-07 2021-06-15 General Electric Company Thermal interposer for a cryogenic cooling system
CN111380743B (zh) * 2020-03-16 2022-09-23 东华理工大学 一种混杂样品顺次软电离装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997298A (en) * 1975-02-27 1976-12-14 Cornell Research Foundation, Inc. Liquid chromatography-mass spectrometry system and method
DE2654057B1 (de) * 1976-11-29 1978-04-27 Varian Mat Gmbh Verfahren zur Ionisierung von organischen Substanzen,sowie dieses Verfahren benutzendes Analysegeraet
DE2819711C2 (de) * 1978-05-05 1984-02-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Verfahren und Vorrichtung zur Analyse einer Probe mit Hilfe gepulster Laserstrahlung
US4230946A (en) * 1979-03-19 1980-10-28 University Of Utah Cryogenic collimator apparatus and method
EP0167561B1 (de) * 1983-12-23 1989-12-06 Sri International Verfahren und vorrichtung zur untersuchung von oberflächen
US4733073A (en) * 1983-12-23 1988-03-22 Sri International Method and apparatus for surface diagnostics
US4594506A (en) * 1984-09-10 1986-06-10 Nicolet Instrument Corporation Gas chromatograph/mass spectrometer interface
DE3517667A1 (de) * 1985-05-15 1986-11-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Laser-massenspektrometer
US4663944A (en) * 1985-07-12 1987-05-12 Cornell Research Foundation, Inc. Cryogenic sample stage for an ion microscope

Also Published As

Publication number Publication date
EP0404934B1 (de) 1994-07-06
JP3057607B2 (ja) 2000-07-04
WO1990008398A1 (en) 1990-07-26
DE69010410T2 (de) 1994-10-20
JPH03503317A (ja) 1991-07-25
CA2025771A1 (en) 1990-07-18
EP0404934A1 (de) 1991-01-02
US4920264A (en) 1990-04-24

Similar Documents

Publication Publication Date Title
DE69010410D1 (de) Verfahren zur vorbereitung von proben für eine massenanalyse mittels desorption von einer gefrorenen lösung.
DE3768533D1 (de) Verfahren zur massenanalyse einer probe.
DE68907407D1 (de) Verfahren zur sequenzanalyse von dna.
DE3783593D1 (de) Verfahren zum betreiben eines analysiergeraets.
DE3752020D1 (de) Spektrometerobjektiv für Korpuskularstrahlmessgeräte und Verfahren zur Untersuchung von Proben.
DE69426731D1 (de) Verfahren zur massenspektroskopischen sequenzanalyse einer nukleinsäure mittels primerverlängerung
ATA213578A (de) Verfahren zur herstellung eines immunologischen testreagens
DE3866427D1 (de) Verfahren zum betreiben eines ionenfallen-massenspektrometers.
DE3887168D1 (de) Verfahren zur quantitativen analyse von mineralien.
DE3586705D1 (de) Verfahren und vorrichtung fuer eine optimale trennung von einer unbekannten probe mittels fluessigkeitschromatographie.
DE3853254D1 (de) Ausrüstungssatz und Verfahren für Analysen von biologischen Proben.
DE3676974D1 (de) Verfahren zur quantitativen messung von kohlenwasserstoffen.
JPS53108904A (en) Reagent for concurrent protein bond analyzing method
DE69022240D1 (de) Verfahren zur vorbereitung einer probe für analyse.
DE3751414D1 (de) Vorrichtung zur Entnahme einer Probe für mikrobiologische Zwecke.
DE69026263D1 (de) Verfahren zur aufbereitung einer zu analysierenden probe
DE69024810D1 (de) Verfahren zur vorbereitung einer probe für analyse
AT384164B (de) Verfahren zur durchfuehrung von wissenschaftlichen, analytischen oder diagnostischen untersuchungen
DE3584563D1 (de) Verfahren zur ausfuehrung eines loesungskonzentrationsprozesses.
DE3789310D1 (de) Verfahren zur feststellung der entwicklungsgeschichte eines körperzustandes aus einer einzigen blutprobe.
DE3769599D1 (de) Verfahren zum analysieren einer haemolysierten blutprobe.
DE3575713D1 (de) Verfahren zur gewinnung von c2+-, c3+- oder von c4+- kohlenwasserstoffen.
DE58908076D1 (de) Verfahren und Entnahmegerät zur Bereitstellung von Bodenproben für Untersuchungen.
DE3761736D1 (de) Vorrichtung zur isotopentrennung oder zur massenanalyse mit hilfe eines magnetfeldes.
AT366062B (de) Verfahren zur gewinnung eines neuen proteins

Legal Events

Date Code Title Description
8364 No opposition during term of opposition