DE3687402T2 - Thrombinzusammensetzung. - Google Patents
Thrombinzusammensetzung.Info
- Publication number
- DE3687402T2 DE3687402T2 DE8686307922T DE3687402T DE3687402T2 DE 3687402 T2 DE3687402 T2 DE 3687402T2 DE 8686307922 T DE8686307922 T DE 8686307922T DE 3687402 T DE3687402 T DE 3687402T DE 3687402 T2 DE3687402 T2 DE 3687402T2
- Authority
- DE
- Germany
- Prior art keywords
- thrombin
- preparation
- buffer
- range
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 239000000203 mixture Substances 0.000 title claims description 19
- 108090000190 Thrombin Proteins 0.000 claims abstract description 84
- 229960004072 thrombin Drugs 0.000 claims abstract description 79
- 238000002360 preparation method Methods 0.000 claims abstract description 52
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 30
- 239000000872 buffer Substances 0.000 claims abstract description 24
- 229920005862 polyol Polymers 0.000 claims abstract description 10
- 150000003077 polyols Chemical class 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 8
- 229940030225 antihemorrhagics Drugs 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000008351 acetate buffer Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 239000002874 hemostatic agent Substances 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 abstract description 12
- 229920001281 polyalkylene Polymers 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 35
- 239000000243 solution Substances 0.000 description 26
- 235000011187 glycerol Nutrition 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 11
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 230000035602 clotting Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 206010053567 Coagulopathies Diseases 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 5
- 229960000583 acetic acid Drugs 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000000701 coagulant Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 239000007991 ACES buffer Substances 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 239000007992 BES buffer Substances 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 239000007987 MES buffer Substances 0.000 description 1
- 239000007993 MOPS buffer Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004353 Polyethylene glycol 8000 Substances 0.000 description 1
- 239000007994 TES buffer Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229940085678 polyethylene glycol 8000 Drugs 0.000 description 1
- 235000019446 polyethylene glycol 8000 Nutrition 0.000 description 1
- FHUOTRMCFQTSOA-UHFFFAOYSA-M potassium;acetic acid;acetate Chemical class [K+].CC(O)=O.CC([O-])=O FHUOTRMCFQTSOA-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical class [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 1
- OTNVGWMVOULBFZ-UHFFFAOYSA-N sodium;hydrochloride Chemical compound [Na].Cl OTNVGWMVOULBFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/22—Blood coagulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/791,836 US4696812A (en) | 1985-10-28 | 1985-10-28 | Thrombin preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3687402D1 DE3687402D1 (de) | 1993-02-11 |
| DE3687402T2 true DE3687402T2 (de) | 1993-05-06 |
Family
ID=25154936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686307922T Revoked DE3687402T2 (de) | 1985-10-28 | 1986-10-14 | Thrombinzusammensetzung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4696812A (https=) |
| EP (1) | EP0221700B1 (https=) |
| JP (1) | JPH0764747B2 (https=) |
| KR (1) | KR870003793A (https=) |
| AT (1) | ATE83927T1 (https=) |
| AU (1) | AU586897B2 (https=) |
| CA (1) | CA1272128A (https=) |
| DE (1) | DE3687402T2 (https=) |
| DK (1) | DK512686A (https=) |
| ES (1) | ES2053442T3 (https=) |
| GR (1) | GR3006727T3 (https=) |
| NZ (1) | NZ217190A (https=) |
| PH (1) | PH23444A (https=) |
| ZA (1) | ZA868223B (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| ZA88227B (en) * | 1987-01-28 | 1988-06-30 | Warner-Lambert Company | Thrombin preparations |
| JPS6440433A (en) * | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
| JP2715104B2 (ja) * | 1988-08-18 | 1998-02-18 | 株式会社ミドリ十字 | トロンビン乾燥製剤 |
| US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
| GB8903438D0 (en) * | 1989-02-15 | 1989-04-05 | May & Baker Ltd | New compositions of matter |
| DK223389D0 (da) * | 1989-05-05 | 1989-05-05 | Ferrosan As | Saarsvamp |
| US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
| US5318524A (en) * | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
| US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
| IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
| JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
| US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
| DE69122376D1 (de) * | 1991-03-28 | 1996-10-31 | Warner Lambert Co | Hochreine Thrombinzubereitung |
| DK83092D0 (da) * | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
| JP3230713B2 (ja) * | 1992-10-23 | 2001-11-19 | トヨタ自動車株式会社 | ピークトルク低減機構 |
| US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
| US5506127A (en) * | 1994-09-21 | 1996-04-09 | Proba; Zbigniew | Therapeutic grade thrombin produced by chromatography |
| CZ318998A3 (cs) * | 1996-04-04 | 1999-09-15 | Baxter Aktiengesellschaft | Hemostatická houba na bázi kolagenu, způsob její přípravy, kryt na ránu a kit k přípravě tohoto krytu |
| WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| JP3927425B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
| JP3401162B2 (ja) * | 1996-11-21 | 2003-04-28 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
| JP3927403B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
| US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
| US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
| AU7320300A (en) * | 1999-09-27 | 2001-04-30 | International Reagents Corporation | Means of stabilizing thrombin and compositions |
| DE10012732A1 (de) | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| US8187625B2 (en) * | 2001-03-12 | 2012-05-29 | Boston Scientific Scimed, Inc. | Cross-linked gelatin composition comprising a wetting agent |
| US7923431B2 (en) * | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
| US7955288B2 (en) | 2002-12-11 | 2011-06-07 | Ferrosan Medical Devices A/S | Gelatine-based materials as swabs |
| US20040243044A1 (en) * | 2003-06-02 | 2004-12-02 | Penegor Stephen A. | Hemostatic wound dressing |
| US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| CA2554994C (en) | 2004-01-30 | 2015-05-19 | Ferrosan A/S | Haemostatic sprays and compositions |
| US7393674B2 (en) * | 2004-06-22 | 2008-07-01 | Zymogenetics, Inc. | Thrombin compositions |
| KR20070046093A (ko) | 2004-07-09 | 2007-05-02 | 훼로산 아크티에 셀스카브 | 히알루론산을 포함하는 지혈 조성물 |
| ATE533491T1 (de) * | 2004-09-21 | 2011-12-15 | Trobio Ab | Stabilisierte protease zusammensetzungen enthaltend eine serinprotease, morpholin-derivate und reversible serinprotease- inhibitoren |
| ES2226587B1 (es) | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
| US7341392B2 (en) * | 2005-04-22 | 2008-03-11 | Dofair Co., Ltd. | Lock device in an articulated joint for a foldable ladder |
| AU2007268175B2 (en) | 2006-05-26 | 2013-05-23 | Baxter Healthcare S.A. | Injectable fibrin composition for bone augmentation |
| JP5315233B2 (ja) * | 2006-05-26 | 2013-10-16 | バクスター・インターナショナル・インコーポレイテッド | 注入可能な骨空隙充填剤 |
| US20100143447A1 (en) * | 2006-12-19 | 2010-06-10 | Ferrosan A/S | Wound or tissue dressing comprising lactic acid bacteria |
| JP5121725B2 (ja) | 2006-12-21 | 2013-01-16 | 積水メディカル株式会社 | トロンビン含有溶液中のα−トロンビンの安定化方法 |
| CA2682034C (en) * | 2007-03-26 | 2015-01-27 | Baxter International Inc. | Injectable void filler for soft tissue augmentation |
| JP5253501B2 (ja) * | 2007-06-15 | 2013-07-31 | ザイモジェネティクス， インコーポレイテッド | 安定化トロンビン組成物 |
| CA2716872C (en) | 2008-02-29 | 2015-02-10 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| US10046081B2 (en) | 2008-04-11 | 2018-08-14 | The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. | Electrospun dextran fibers and devices formed therefrom |
| JP5437236B2 (ja) * | 2008-04-16 | 2014-03-12 | 一般財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性シート製剤の製造方法 |
| CN104159527B (zh) | 2012-03-06 | 2017-04-12 | 弗罗桑医疗设备公司 | 包含止血糊剂的压力容器 |
| RU2636240C2 (ru) | 2012-06-12 | 2017-11-21 | Ферросан Медикал Дивайсиз А/С | Сухая гемостатическая композиция |
| US9149529B2 (en) | 2012-10-24 | 2015-10-06 | Orthovita, Inc. | Stable compositions containing thrombin and methods for preparation and use thereof |
| JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー／エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
| BR112016013322B1 (pt) | 2013-12-11 | 2020-07-21 | Ferrosan Medical Devices A/S | métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit |
| BR112017007466B1 (pt) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
| RU2705905C2 (ru) | 2014-12-24 | 2019-11-12 | Ферросан Медикал Дивайсиз А/С | Шприц для удерживания и смешивания первого и второго веществ |
| CN104630325B (zh) * | 2015-02-04 | 2018-03-02 | 上海长岛生物技术有限公司 | 一种液体型纤维蛋白原检测试剂及其制备方法 |
| CN104569446A (zh) * | 2015-02-04 | 2015-04-29 | 上海长岛生物技术有限公司 | 一种液体型凝血酶时间检测试剂及其制备方法 |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| CA3004734A1 (en) | 2015-11-12 | 2017-06-18 | St. Teresa Medical, Inc. | A method of sealing a durotomy |
| US10953128B2 (en) | 2017-11-02 | 2021-03-23 | St. Teresa Medical, Inc. | Fibrin sealant products |
| EP4321182A3 (en) | 2018-05-09 | 2024-05-29 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
| IL261190A (en) | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
| IL262716A (en) * | 2018-11-01 | 2018-11-29 | Omrix Biopharmaceuticals Ltd | Oxidized cellulose preparations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2433299A (en) * | 1944-01-22 | 1947-12-23 | Parke Davis & Co | Blood coagulant and method of preserving same |
| US2532348A (en) * | 1946-12-12 | 1950-12-05 | Szent-Gyorgyi Albert | Blood clotting preparation |
| JPS536483A (en) * | 1976-07-02 | 1978-01-20 | Tanabe Seiyaku Co Ltd | Composition having enzymatic activity and its preparation |
| JPS5639782A (en) * | 1979-09-04 | 1981-04-15 | Dai Ichi Pure Chem Co Ltd | Stabilization of thrombin |
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| JPS628137A (ja) * | 1985-07-05 | 1987-01-16 | Konishiroku Photo Ind Co Ltd | 情報記録装置 |
-
1985
- 1985-10-28 US US06/791,836 patent/US4696812A/en not_active Expired - Fee Related
-
1986
- 1986-08-13 NZ NZ217190A patent/NZ217190A/xx unknown
- 1986-10-14 EP EP86307922A patent/EP0221700B1/en not_active Expired - Lifetime
- 1986-10-14 AT AT86307922T patent/ATE83927T1/de not_active IP Right Cessation
- 1986-10-14 DE DE8686307922T patent/DE3687402T2/de not_active Revoked
- 1986-10-14 ES ES86307922T patent/ES2053442T3/es not_active Expired - Lifetime
- 1986-10-16 PH PH34377A patent/PH23444A/en unknown
- 1986-10-27 KR KR1019860008973A patent/KR870003793A/ko not_active Abandoned
- 1986-10-27 CA CA000521494A patent/CA1272128A/en not_active Expired - Fee Related
- 1986-10-27 JP JP61253900A patent/JPH0764747B2/ja not_active Expired - Lifetime
- 1986-10-27 DK DK512686A patent/DK512686A/da not_active Application Discontinuation
- 1986-10-28 ZA ZA868223A patent/ZA868223B/xx unknown
- 1986-10-28 AU AU64517/86A patent/AU586897B2/en not_active Ceased
-
1992
- 1992-12-31 GR GR920403095T patent/GR3006727T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR870003793A (ko) | 1987-05-04 |
| DK512686D0 (da) | 1986-10-27 |
| EP0221700A2 (en) | 1987-05-13 |
| PH23444A (en) | 1989-08-07 |
| ZA868223B (en) | 1987-07-29 |
| EP0221700B1 (en) | 1992-12-30 |
| JPS62106028A (ja) | 1987-05-16 |
| ATE83927T1 (de) | 1993-01-15 |
| JPH0764747B2 (ja) | 1995-07-12 |
| GR3006727T3 (https=) | 1993-06-30 |
| AU586897B2 (en) | 1989-07-27 |
| DE3687402D1 (de) | 1993-02-11 |
| NZ217190A (en) | 1989-05-29 |
| US4696812A (en) | 1987-09-29 |
| EP0221700A3 (en) | 1987-08-26 |
| DK512686A (da) | 1987-04-29 |
| AU6451786A (en) | 1987-04-30 |
| ES2053442T3 (es) | 1994-08-01 |
| CA1272128A (en) | 1990-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3687402T2 (de) | Thrombinzusammensetzung. | |
| US4965203A (en) | Purified thrombin preparations | |
| US3868358A (en) | Protamine-insulin product | |
| DE69629209T2 (de) | Getrocknete zubereitung von bluttfaktoren, enthaltend trehalose | |
| EP0244834B1 (de) | Verfahren zur Herstellung eines Faktor V-Konzentrats | |
| DE69729786T2 (de) | Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen | |
| DE69333928T2 (de) | Verbesserte solubilisierung und stabilisierung des faktor viii-komplexes | |
| EP1131110B1 (de) | Stabilisierte proteinzubereitungen für einen gewebekleber | |
| EP0478827B1 (de) | Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens | |
| DE3686410T2 (de) | Stabilisierte zusammensetzungen von menschlichen aktivatoren des gewebeplasminogens. | |
| EP1136084B1 (de) | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung | |
| DE3872534T2 (https=) | ||
| DE69630291T2 (de) | Proteinformulierung, die koajulationsfehler viii oder ix in einer saccharose wässriger lösung enthält | |
| EP1572229B1 (de) | Stabiles therapeutisches fibrinogen | |
| DE2917899A1 (de) | Lyophilisierte urokinasezubereitung zu injektionszwecken und verfahren zu ihrer herstellung | |
| DD289470A5 (de) | Verfahren zur herstellung eines arzneimittels mit einem gehalt an gamma-interferon | |
| EP1221479B1 (en) | Method for stabilizing thrombin | |
| DE69425581T2 (de) | Methode zur stabilisierung von protein c oder aktiviertem protein c und stabilisierte verbindungen | |
| EP3538898B1 (de) | Prothrombinzeit-reagenz enthaltend einen eisenchelator | |
| EP0458950B1 (de) | K2p pro-stabilisierung | |
| DE19853033A1 (de) | Stabilisierte Proteinzubereitung für einen Gewebekleber | |
| DE69101784T2 (de) | Stabilisierte zusammensetzung enthaltend ein fibroblastwachstumsfaktor. | |
| DE69001110T2 (de) | Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon. | |
| CA1289472C (en) | Tpa-containing medical composition | |
| EP0458929B1 (de) | t-PA-Solubilisierung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8331 | Complete revocation |