KR870003793A - 트롬빈 제재의 방법 - Google Patents
트롬빈 제재의 방법 Download PDFInfo
- Publication number
- KR870003793A KR870003793A KR1019860008973A KR860008973A KR870003793A KR 870003793 A KR870003793 A KR 870003793A KR 1019860008973 A KR1019860008973 A KR 1019860008973A KR 860008973 A KR860008973 A KR 860008973A KR 870003793 A KR870003793 A KR 870003793A
- Authority
- KR
- South Korea
- Prior art keywords
- thrombin
- preparation
- sanctions
- buffer
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/22—Blood coagulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 생성물의 최종 pH가 약 5.0 내지 약 6.0이 되도록, 트롬빈을 자기분해 방지량과 접촉시키는 단계로 구성되는 안정화된 제제를 포함하는 생성물을 제조하는 방법.
- 제1항에 있어서, 최종 pH가 약 5.3인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/791,836 US4696812A (en) | 1985-10-28 | 1985-10-28 | Thrombin preparations |
US791.836 | 1985-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870003793A true KR870003793A (ko) | 1987-05-04 |
Family
ID=25154936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860008973A KR870003793A (ko) | 1985-10-28 | 1986-10-27 | 트롬빈 제재의 방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4696812A (ko) |
EP (1) | EP0221700B1 (ko) |
JP (1) | JPH0764747B2 (ko) |
KR (1) | KR870003793A (ko) |
AT (1) | ATE83927T1 (ko) |
AU (1) | AU586897B2 (ko) |
CA (1) | CA1272128A (ko) |
DE (1) | DE3687402T2 (ko) |
DK (1) | DK512686A (ko) |
ES (1) | ES2053442T3 (ko) |
GR (1) | GR3006727T3 (ko) |
NZ (1) | NZ217190A (ko) |
PH (1) | PH23444A (ko) |
ZA (1) | ZA868223B (ko) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
ZA88227B (en) * | 1987-01-28 | 1988-06-30 | Warner-Lambert Company | Thrombin preparations |
JPS6440433A (en) * | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
JP2715104B2 (ja) * | 1988-08-18 | 1998-02-18 | 株式会社ミドリ十字 | トロンビン乾燥製剤 |
US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
GB8903438D0 (en) * | 1989-02-15 | 1989-04-05 | May & Baker Ltd | New compositions of matter |
DK223389D0 (da) * | 1989-05-05 | 1989-05-05 | Ferrosan As | Saarsvamp |
US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
US5318524A (en) * | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
EP0505604B1 (en) * | 1991-03-28 | 1996-09-25 | Warner-Lambert Company | Highly purified thrombin preparation |
DK83092D0 (da) * | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
JP3230713B2 (ja) * | 1992-10-23 | 2001-11-19 | トヨタ自動車株式会社 | ピークトルク低減機構 |
US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
US5506127A (en) * | 1994-09-21 | 1996-04-09 | Proba; Zbigniew | Therapeutic grade thrombin produced by chromatography |
HUP9903586A3 (en) * | 1996-04-04 | 2003-02-28 | Baxter Ag | Hemostatic sponge based on collagen |
WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
JP3927403B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
JP3927425B2 (ja) * | 1996-11-21 | 2007-06-06 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
JP3401162B2 (ja) * | 1996-11-21 | 2003-04-28 | 積水化学工業株式会社 | 血液凝固促進剤及び血液検査用容器 |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
DE60032001T2 (de) * | 1999-09-27 | 2007-05-31 | Sysmex Corp. | Verfahren zur stabilisierung von thrombin |
DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
US8187625B2 (en) * | 2001-03-12 | 2012-05-29 | Boston Scientific Scimed, Inc. | Cross-linked gelatin composition comprising a wetting agent |
US7923431B2 (en) * | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
BR0317237A (pt) | 2002-12-11 | 2005-11-01 | Ferrosan As | Dispositivo para amostragem ou coleta, kit, usos de um dispositivo e de um kit, e, métodos para diminuir a quantidade de um marcador em uma área de amostra, para amostrar de modo qualitativo ou quantitativo uma área quanto ao teor de um marcador e para cultivar microorganismos ou células de mamìferos coletados |
US20040243044A1 (en) * | 2003-06-02 | 2004-12-02 | Penegor Stephen A. | Hemostatic wound dressing |
US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
AR054637A1 (es) | 2004-01-30 | 2007-07-11 | Ferrosan As | Aerosoles y composiciones hemostaticas |
ES2395466T3 (es) * | 2004-06-22 | 2013-02-12 | Zymogenetics, Inc. | Composiciones de trombina |
EP1786480B1 (en) | 2004-07-09 | 2016-09-21 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
ATE533491T1 (de) * | 2004-09-21 | 2011-12-15 | Trobio Ab | Stabilisierte protease zusammensetzungen enthaltend eine serinprotease, morpholin-derivate und reversible serinprotease- inhibitoren |
ES2226587B1 (es) * | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
US7341392B2 (en) * | 2005-04-22 | 2008-03-11 | Dofair Co., Ltd. | Lock device in an articulated joint for a foldable ladder |
EP2029184B1 (en) | 2006-05-26 | 2011-02-23 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
KR101421750B1 (ko) * | 2006-05-26 | 2014-07-22 | 박스터 헬쓰케어 에스에이 | 주입가능한 골 결함 충전제 |
US20100143447A1 (en) * | 2006-12-19 | 2010-06-10 | Ferrosan A/S | Wound or tissue dressing comprising lactic acid bacteria |
US8580532B2 (en) * | 2006-12-21 | 2013-11-12 | Sekisui Medical Co., Ltd. | Method for stabilizing α-thrombin in thrombin-containing solution |
ES2381448T3 (es) * | 2007-03-26 | 2012-05-28 | Baxter International Inc. | Material de relleno de huecos inyectable par el aumento de tejidos blandos |
CA2687968C (en) * | 2007-06-15 | 2016-09-27 | Zymogenetics, Inc. | Stabilized thrombin compositions |
JP5569398B2 (ja) | 2008-02-29 | 2014-08-13 | フェッローサン メディカル ディバイス エー/エス | 止血および/または創傷治癒を促進するための装置 |
US9149557B2 (en) * | 2008-04-16 | 2015-10-06 | The Chemo-Sero-Therapeutic Research Institute | Process for preparing bioabsorbable sheet preparation holding thrombin |
CA2865349C (en) | 2012-03-06 | 2021-07-06 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
CA2874290C (en) | 2012-06-12 | 2020-02-25 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US9149529B2 (en) | 2012-10-24 | 2015-10-06 | Orthovita, Inc. | Stable compositions containing thrombin and methods for preparation and use thereof |
CN105358071B (zh) | 2013-06-21 | 2018-07-31 | 弗罗桑医疗设备公司 | 真空膨胀的干组合物和用于保留该干组合物的注射器 |
CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
WO2016058612A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
EP3237041B1 (en) | 2014-12-24 | 2020-01-29 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
CN104630325B (zh) * | 2015-02-04 | 2018-03-02 | 上海长岛生物技术有限公司 | 一种液体型纤维蛋白原检测试剂及其制备方法 |
CN104569446A (zh) * | 2015-02-04 | 2015-04-29 | 上海长岛生物技术有限公司 | 一种液体型凝血酶时间检测试剂及其制备方法 |
BR112017027695A2 (pt) | 2015-07-03 | 2018-09-04 | Ferrosan Medical Devices As | seringa para retenção e mistura de primeira e segunda substâncias |
EP3373853A4 (en) | 2015-11-12 | 2019-07-10 | St. Teresa Medical, Inc. | METHOD FOR SEALING A DUROTOMY |
US10953128B2 (en) | 2017-11-02 | 2021-03-23 | St. Teresa Medical, Inc. | Fibrin sealant products |
MX2020011866A (es) | 2018-05-09 | 2021-01-20 | Ferrosan Medical Devices As | Metodo para preparar una composicion hemostatica. |
IL261190A (en) * | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
IL262716A (en) * | 2018-11-01 | 2018-11-29 | Omrix Biopharmaceuticals Ltd | Oxidized cellulose preparations |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2433299A (en) * | 1944-01-22 | 1947-12-23 | Parke Davis & Co | Blood coagulant and method of preserving same |
US2532348A (en) * | 1946-12-12 | 1950-12-05 | Szent-Gyorgyi Albert | Blood clotting preparation |
JPS536483A (en) * | 1976-07-02 | 1978-01-20 | Tanabe Seiyaku Co Ltd | Composition having enzymatic activity and its preparation |
JPS5639782A (en) * | 1979-09-04 | 1981-04-15 | Dai Ichi Pure Chem Co Ltd | Stabilization of thrombin |
US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
JPS628137A (ja) * | 1985-07-05 | 1987-01-16 | Konishiroku Photo Ind Co Ltd | 情報記録装置 |
-
1985
- 1985-10-28 US US06/791,836 patent/US4696812A/en not_active Expired - Fee Related
-
1986
- 1986-08-13 NZ NZ217190A patent/NZ217190A/xx unknown
- 1986-10-14 ES ES86307922T patent/ES2053442T3/es not_active Expired - Lifetime
- 1986-10-14 DE DE8686307922T patent/DE3687402T2/de not_active Revoked
- 1986-10-14 AT AT86307922T patent/ATE83927T1/de not_active IP Right Cessation
- 1986-10-14 EP EP86307922A patent/EP0221700B1/en not_active Expired - Lifetime
- 1986-10-16 PH PH34377A patent/PH23444A/en unknown
- 1986-10-27 KR KR1019860008973A patent/KR870003793A/ko not_active IP Right Cessation
- 1986-10-27 DK DK512686A patent/DK512686A/da not_active Application Discontinuation
- 1986-10-27 JP JP61253900A patent/JPH0764747B2/ja not_active Expired - Lifetime
- 1986-10-27 CA CA000521494A patent/CA1272128A/en not_active Expired - Fee Related
- 1986-10-28 ZA ZA868223A patent/ZA868223B/xx unknown
- 1986-10-28 AU AU64517/86A patent/AU586897B2/en not_active Ceased
-
1992
- 1992-12-31 GR GR920403095T patent/GR3006727T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0764747B2 (ja) | 1995-07-12 |
ZA868223B (en) | 1987-07-29 |
AU6451786A (en) | 1987-04-30 |
ES2053442T3 (es) | 1994-08-01 |
EP0221700B1 (en) | 1992-12-30 |
DE3687402D1 (de) | 1993-02-11 |
DK512686A (da) | 1987-04-29 |
EP0221700A3 (en) | 1987-08-26 |
CA1272128A (en) | 1990-07-31 |
AU586897B2 (en) | 1989-07-27 |
GR3006727T3 (ko) | 1993-06-30 |
EP0221700A2 (en) | 1987-05-13 |
NZ217190A (en) | 1989-05-29 |
DK512686D0 (da) | 1986-10-27 |
US4696812A (en) | 1987-09-29 |
PH23444A (en) | 1989-08-07 |
JPS62106028A (ja) | 1987-05-16 |
ATE83927T1 (de) | 1993-01-15 |
DE3687402T2 (de) | 1993-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
SUBM | Surrender of laid-open application requested |