JPS5639782A - Stabilization of thrombin - Google Patents
Stabilization of thrombinInfo
- Publication number
- JPS5639782A JPS5639782A JP11245479A JP11245479A JPS5639782A JP S5639782 A JPS5639782 A JP S5639782A JP 11245479 A JP11245479 A JP 11245479A JP 11245479 A JP11245479 A JP 11245479A JP S5639782 A JPS5639782 A JP S5639782A
- Authority
- JP
- Japan
- Prior art keywords
- thrombin
- solution
- monofunctional
- soluble organic
- stabilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 3
- 229960004072 thrombin Drugs 0.000 title abstract 3
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 3
- 150000007942 carboxylates Chemical class 0.000 abstract 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 235000011083 sodium citrates Nutrition 0.000 abstract 1
- 239000001476 sodium potassium tartrate Substances 0.000 abstract 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 abstract 1
Abstract
PURPOSE: To stabilize a thrombin solution, by adding a monofunctional or polyfunctional water-soluble organic carboxylate.
CONSTITUTION: An aqueous solution with a weak alkalinity usually in pH 7W9 is prepared from one or a combination of two or more of monofunctional or polyfunctional water-soluble organic carboxylates, e.g., sodium acetate, sodium citrate, sodium potassium tartrate, etc., and the solution is added to a thrombin solution.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11245479A JPS5639782A (en) | 1979-09-04 | 1979-09-04 | Stabilization of thrombin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11245479A JPS5639782A (en) | 1979-09-04 | 1979-09-04 | Stabilization of thrombin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5639782A true JPS5639782A (en) | 1981-04-15 |
Family
ID=14587035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11245479A Pending JPS5639782A (en) | 1979-09-04 | 1979-09-04 | Stabilization of thrombin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5639782A (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59126475A (en) * | 1983-01-07 | 1984-07-21 | Toray Silicone Co Ltd | Composition for forming releasable film |
JPS62106028A (en) * | 1985-10-28 | 1987-05-16 | ワ−ナ−−ランバ−ト・コンパニ− | Thrombin preparation |
JPS63192723A (en) * | 1987-01-28 | 1988-08-10 | ワーナー‐ランバート・コンパニー | Thrombin medicine |
US4843461A (en) * | 1985-06-25 | 1989-06-27 | Matsushita Electric Works, Ltd. | Over-door interphone system provided with a night-vision monitoring device |
JPH0253732A (en) * | 1988-08-18 | 1990-02-22 | Green Cross Corp:The | Dried preparation of thrombin |
WO2001023536A1 (en) * | 1999-09-27 | 2001-04-05 | International Reagents Corporation | Means of stabilizing thrombin and compositions |
JP2001261574A (en) * | 2000-03-18 | 2001-09-26 | Aventis Behring Gmbh | Thrombin pharmaceutical preparation and method for producing the same |
JP2002195995A (en) * | 1996-11-21 | 2002-07-10 | Sekisui Chem Co Ltd | Blood coagulation accelerant and container for blood test |
JP2002323488A (en) * | 1996-11-21 | 2002-11-08 | Sekisui Chem Co Ltd | Blood coagulation accelerator and container for blood test |
EP1649867A1 (en) * | 2004-10-22 | 2006-04-26 | Grifols, S.A. | Stable thrombin composition |
WO2009128474A1 (en) | 2008-04-16 | 2009-10-22 | 財団法人化学及血清療法研究所 | Method of producing thrombin-immobilized bioabsorbable sheet preparation |
US9949473B2 (en) | 2011-07-05 | 2018-04-24 | Becton, Dickinson And Company | Coagulation controlling agents and devices comprising the same |
-
1979
- 1979-09-04 JP JP11245479A patent/JPS5639782A/en active Pending
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH023832B2 (en) * | 1983-01-07 | 1990-01-25 | Toray Silicone Co | |
JPS59126475A (en) * | 1983-01-07 | 1984-07-21 | Toray Silicone Co Ltd | Composition for forming releasable film |
US4843461A (en) * | 1985-06-25 | 1989-06-27 | Matsushita Electric Works, Ltd. | Over-door interphone system provided with a night-vision monitoring device |
JPS62106028A (en) * | 1985-10-28 | 1987-05-16 | ワ−ナ−−ランバ−ト・コンパニ− | Thrombin preparation |
JPH0764747B2 (en) * | 1985-10-28 | 1995-07-12 | ワ−ナ−−ランバ−ト・コンパニ− | Thrombin preparation |
JPS63192723A (en) * | 1987-01-28 | 1988-08-10 | ワーナー‐ランバート・コンパニー | Thrombin medicine |
JPH0253732A (en) * | 1988-08-18 | 1990-02-22 | Green Cross Corp:The | Dried preparation of thrombin |
JP2002323488A (en) * | 1996-11-21 | 2002-11-08 | Sekisui Chem Co Ltd | Blood coagulation accelerator and container for blood test |
JP2002195995A (en) * | 1996-11-21 | 2002-07-10 | Sekisui Chem Co Ltd | Blood coagulation accelerant and container for blood test |
WO2001023536A1 (en) * | 1999-09-27 | 2001-04-05 | International Reagents Corporation | Means of stabilizing thrombin and compositions |
JP2001261574A (en) * | 2000-03-18 | 2001-09-26 | Aventis Behring Gmbh | Thrombin pharmaceutical preparation and method for producing the same |
US7351561B2 (en) | 2000-03-18 | 2008-04-01 | Csl Behring Gmbh | Thrombin preparations and process for their production |
US8012728B2 (en) | 2000-03-18 | 2011-09-06 | Csl Behring Gmbh | Thrombin preparations and process for their production |
EP1649867A1 (en) * | 2004-10-22 | 2006-04-26 | Grifols, S.A. | Stable thrombin composition |
US9376674B2 (en) | 2004-10-22 | 2016-06-28 | Grifols, S.A. | Process to prepare a stable thrombin composition |
WO2009128474A1 (en) | 2008-04-16 | 2009-10-22 | 財団法人化学及血清療法研究所 | Method of producing thrombin-immobilized bioabsorbable sheet preparation |
US9149557B2 (en) | 2008-04-16 | 2015-10-06 | The Chemo-Sero-Therapeutic Research Institute | Process for preparing bioabsorbable sheet preparation holding thrombin |
US9949473B2 (en) | 2011-07-05 | 2018-04-24 | Becton, Dickinson And Company | Coagulation controlling agents and devices comprising the same |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5639782A (en) | Stabilization of thrombin | |
JPS53109555A (en) | Preparation of modified keratin-containing material | |
JPS5318529A (en) | Optically active mandelic acid phenylglycinol salt and its preparation | |
JPS5253427A (en) | Color photograph processing | |
JPS5254084A (en) | Manufacture of 2-gamma-glutamylamino-4-hexynic acid and/or 2-gamma-glutamylamino- 3-hydroxy-4-hexynic acid | |
JPS5422326A (en) | 3-trimethylsilymethyl-3-butenoic acid and its preparation | |
JPS5250690A (en) | Etching process | |
JPS5210487A (en) | Production of gluconic acid or salts thereof by fermentation | |
JPS5639783A (en) | Fixed protease and its preparation | |
JPS538371A (en) | Preserving method for selectively permeable membrane | |
JPS5419939A (en) | Antibiotic xk-62-4 and its preparation | |
JPS54132527A (en) | Production of stabilized aqueous solution of iron complex salt | |
JPS51134899A (en) | Processing method of magnetic powder | |
JPS51128676A (en) | A method of treating gas containing nitrogen oxides | |
JPS5254083A (en) | Microbial productio of glicolipids | |
JPS5228490A (en) | Uranium adsorbent | |
JPS5228489A (en) | Uranium adsorbent | |
JPS53133300A (en) | Preparation of etherified polyoxyalkylene compound | |
JPS5334988A (en) | Aminocyclitol derivative and its preparation | |
JPS5377805A (en) | Wet treating method for manganese noduls | |
JPS51121519A (en) | Additives for the dilute solutions of agricultural chemicals | |
JPS5238492A (en) | Preventing sulfite from oxidation | |
JPS5325267A (en) | Removing method for oxygen existing in aqueous system | |
JPS537686A (en) | 6-oxo-2-piperzinylacetic acid and its preparation | |
JPS52113935A (en) | Preparation of aqueous concentrated solution of s-benzyl-l-cysteine-p- nitroanilide |