JPS5639782A - Stabilization of thrombin - Google Patents

Stabilization of thrombin

Info

Publication number
JPS5639782A
JPS5639782A JP11245479A JP11245479A JPS5639782A JP S5639782 A JPS5639782 A JP S5639782A JP 11245479 A JP11245479 A JP 11245479A JP 11245479 A JP11245479 A JP 11245479A JP S5639782 A JPS5639782 A JP S5639782A
Authority
JP
Japan
Prior art keywords
thrombin
solution
monofunctional
soluble organic
stabilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11245479A
Other languages
Japanese (ja)
Inventor
Kazuo Suga
Akemichi Maki
Mitsugi Hibino
Tetsuyoshi Yokojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Kagaku Yakuhin Co Ltd
Daiichi Pure Chemicals Co Ltd
Original Assignee
Daiichi Kagaku Yakuhin Co Ltd
Daiichi Pure Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Kagaku Yakuhin Co Ltd, Daiichi Pure Chemicals Co Ltd filed Critical Daiichi Kagaku Yakuhin Co Ltd
Priority to JP11245479A priority Critical patent/JPS5639782A/en
Publication of JPS5639782A publication Critical patent/JPS5639782A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To stabilize a thrombin solution, by adding a monofunctional or polyfunctional water-soluble organic carboxylate.
CONSTITUTION: An aqueous solution with a weak alkalinity usually in pH 7W9 is prepared from one or a combination of two or more of monofunctional or polyfunctional water-soluble organic carboxylates, e.g., sodium acetate, sodium citrate, sodium potassium tartrate, etc., and the solution is added to a thrombin solution.
COPYRIGHT: (C)1981,JPO&Japio
JP11245479A 1979-09-04 1979-09-04 Stabilization of thrombin Pending JPS5639782A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11245479A JPS5639782A (en) 1979-09-04 1979-09-04 Stabilization of thrombin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11245479A JPS5639782A (en) 1979-09-04 1979-09-04 Stabilization of thrombin

Publications (1)

Publication Number Publication Date
JPS5639782A true JPS5639782A (en) 1981-04-15

Family

ID=14587035

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11245479A Pending JPS5639782A (en) 1979-09-04 1979-09-04 Stabilization of thrombin

Country Status (1)

Country Link
JP (1) JPS5639782A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59126475A (en) * 1983-01-07 1984-07-21 Toray Silicone Co Ltd Composition for forming releasable film
JPS62106028A (en) * 1985-10-28 1987-05-16 ワ−ナ−−ランバ−ト・コンパニ− Thrombin preparation
JPS63192723A (en) * 1987-01-28 1988-08-10 ワーナー‐ランバート・コンパニー Thrombin medicine
US4843461A (en) * 1985-06-25 1989-06-27 Matsushita Electric Works, Ltd. Over-door interphone system provided with a night-vision monitoring device
JPH0253732A (en) * 1988-08-18 1990-02-22 Green Cross Corp:The Dried preparation of thrombin
WO2001023536A1 (en) * 1999-09-27 2001-04-05 International Reagents Corporation Means of stabilizing thrombin and compositions
JP2001261574A (en) * 2000-03-18 2001-09-26 Aventis Behring Gmbh Thrombin pharmaceutical preparation and method for producing the same
JP2002195995A (en) * 1996-11-21 2002-07-10 Sekisui Chem Co Ltd Blood coagulation accelerant and container for blood test
JP2002323488A (en) * 1996-11-21 2002-11-08 Sekisui Chem Co Ltd Blood coagulation accelerator and container for blood test
EP1649867A1 (en) * 2004-10-22 2006-04-26 Grifols, S.A. Stable thrombin composition
WO2009128474A1 (en) 2008-04-16 2009-10-22 財団法人化学及血清療法研究所 Method of producing thrombin-immobilized bioabsorbable sheet preparation
US9949473B2 (en) 2011-07-05 2018-04-24 Becton, Dickinson And Company Coagulation controlling agents and devices comprising the same

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH023832B2 (en) * 1983-01-07 1990-01-25 Toray Silicone Co
JPS59126475A (en) * 1983-01-07 1984-07-21 Toray Silicone Co Ltd Composition for forming releasable film
US4843461A (en) * 1985-06-25 1989-06-27 Matsushita Electric Works, Ltd. Over-door interphone system provided with a night-vision monitoring device
JPS62106028A (en) * 1985-10-28 1987-05-16 ワ−ナ−−ランバ−ト・コンパニ− Thrombin preparation
JPH0764747B2 (en) * 1985-10-28 1995-07-12 ワ−ナ−−ランバ−ト・コンパニ− Thrombin preparation
JPS63192723A (en) * 1987-01-28 1988-08-10 ワーナー‐ランバート・コンパニー Thrombin medicine
JPH0253732A (en) * 1988-08-18 1990-02-22 Green Cross Corp:The Dried preparation of thrombin
JP2002323488A (en) * 1996-11-21 2002-11-08 Sekisui Chem Co Ltd Blood coagulation accelerator and container for blood test
JP2002195995A (en) * 1996-11-21 2002-07-10 Sekisui Chem Co Ltd Blood coagulation accelerant and container for blood test
WO2001023536A1 (en) * 1999-09-27 2001-04-05 International Reagents Corporation Means of stabilizing thrombin and compositions
JP2001261574A (en) * 2000-03-18 2001-09-26 Aventis Behring Gmbh Thrombin pharmaceutical preparation and method for producing the same
US7351561B2 (en) 2000-03-18 2008-04-01 Csl Behring Gmbh Thrombin preparations and process for their production
US8012728B2 (en) 2000-03-18 2011-09-06 Csl Behring Gmbh Thrombin preparations and process for their production
EP1649867A1 (en) * 2004-10-22 2006-04-26 Grifols, S.A. Stable thrombin composition
US9376674B2 (en) 2004-10-22 2016-06-28 Grifols, S.A. Process to prepare a stable thrombin composition
WO2009128474A1 (en) 2008-04-16 2009-10-22 財団法人化学及血清療法研究所 Method of producing thrombin-immobilized bioabsorbable sheet preparation
US9149557B2 (en) 2008-04-16 2015-10-06 The Chemo-Sero-Therapeutic Research Institute Process for preparing bioabsorbable sheet preparation holding thrombin
US9949473B2 (en) 2011-07-05 2018-04-24 Becton, Dickinson And Company Coagulation controlling agents and devices comprising the same

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