DE3650567T2 - Medizinische Indol- und Indazol-Ketosulfonderivate - Google Patents

Medizinische Indol- und Indazol-Ketosulfonderivate

Info

Publication number
DE3650567T2
DE3650567T2 DE3650567T DE3650567T DE3650567T2 DE 3650567 T2 DE3650567 T2 DE 3650567T2 DE 3650567 T DE3650567 T DE 3650567T DE 3650567 T DE3650567 T DE 3650567T DE 3650567 T2 DE3650567 T2 DE 3650567T2
Authority
DE
Germany
Prior art keywords
indazole
indole
medical
ketosulfone derivatives
ketosulfone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3650567T
Other languages
English (en)
Other versions
DE3650567D1 (de
Inventor
Peter Robert Bernstein
Frederick Jeffrey Brown
Victor Giulio Matassa
Ying Kwong Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Zeneca Inc
Original Assignee
Zeneca Ltd
Zeneca Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858525657A external-priority patent/GB8525657D0/en
Priority claimed from GB868609177A external-priority patent/GB8609177D0/en
Application filed by Zeneca Ltd, Zeneca Inc filed Critical Zeneca Ltd
Publication of DE3650567D1 publication Critical patent/DE3650567D1/de
Application granted granted Critical
Publication of DE3650567T2 publication Critical patent/DE3650567T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE3650567T 1985-10-17 1986-10-16 Medizinische Indol- und Indazol-Ketosulfonderivate Expired - Fee Related DE3650567T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858525657A GB8525657D0 (en) 1985-10-17 1985-10-17 Heterocyclic compounds
GB868609177A GB8609177D0 (en) 1986-04-15 1986-04-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
DE3650567D1 DE3650567D1 (de) 1996-10-17
DE3650567T2 true DE3650567T2 (de) 1997-02-20

Family

ID=26289899

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3650567T Expired - Fee Related DE3650567T2 (de) 1985-10-17 1986-10-16 Medizinische Indol- und Indazol-Ketosulfonderivate

Country Status (13)

Country Link
US (1) US4837235A (de)
EP (1) EP0227241B1 (de)
JP (1) JPH07107047B2 (de)
AU (1) AU609704B2 (de)
CA (1) CA1335450C (de)
DE (1) DE3650567T2 (de)
DK (1) DK496086A (de)
FI (1) FI864190A (de)
IE (1) IE862737L (de)
IL (1) IL80336A (de)
NO (1) NO864131L (de)
NZ (1) NZ217961A (de)
PT (1) PT83559B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
US5041460A (en) * 1988-04-14 1991-08-20 Ici Americas Inc. Heter-aliphatic carboxamides
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
EP0455596B1 (de) * 1990-05-04 1994-11-02 Novartis AG Substituierte Indole
EP0485337B1 (de) * 1990-11-08 1995-04-19 Ciba-Geigy Ag Pyrazol enthaltende Pigmentderivate
US5334597A (en) * 1991-10-17 1994-08-02 Merck Frosst Canada, Inc. Indole carbamates as leukotriene antagonists
EP0539330B1 (de) * 1991-10-25 1995-05-17 Ciba-Geigy Ag Verfahren zur Herstellung substituierter Indole
EP0539329A1 (de) * 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
US5280039A (en) * 1992-11-04 1994-01-18 Pfizer Inc. Bicyclic carbamates and methods of treating inflammatory diseases using the same
US5439929A (en) * 1994-03-01 1995-08-08 Pfizer Inc. Bicyclic carbamates, pharmaceutical compositions and use
WO2001007031A1 (fr) * 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant
CN101263121A (zh) 2005-07-14 2008-09-10 塔克达圣地亚哥公司 组蛋白脱乙酰基酶抑制剂
EP1919866A2 (de) 2005-08-17 2008-05-14 Wyeth a Corporation of the State of Delaware Substituierte indole und deren verwendung
US8178573B2 (en) * 2006-04-20 2012-05-15 Glaxo Group Limited Compounds
EP2352501B1 (de) * 2008-11-03 2014-01-01 ChemoCentryx, Inc. Verbindung zur verwendung in der behandlung von osteoporose

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT234103B (de) * 1959-09-03 1964-06-10 Merck & Co Inc Verfahren zur Herstellung von neuen, benzylindolylsubstituierten niedrigen aliphatischen Säuren sowie deren Salzen und Estern
US3271416A (en) * 1961-10-24 1966-09-06 Merck & Co Inc Indolyl aliphatic acids
FR4035M (de) * 1964-11-04 1966-03-28
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
DE2854987A1 (de) * 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene
IE54269B1 (en) * 1981-12-30 1989-08-02 Ici America Inc Pharmaceutically active phenylcarboxylic acid derivatives
CA1241660A (en) * 1984-06-25 1988-09-06 Yvan Guindon Indole-2-alkanoic acids
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides

Also Published As

Publication number Publication date
AU609704B2 (en) 1991-05-09
NO864131L (no) 1987-04-21
NZ217961A (en) 1990-06-26
EP0227241A3 (de) 1988-08-03
JPS6296465A (ja) 1987-05-02
EP0227241A2 (de) 1987-07-01
NO864131D0 (no) 1986-10-16
DE3650567D1 (de) 1996-10-17
JPH07107047B2 (ja) 1995-11-15
PT83559B (pt) 1989-05-31
EP0227241B1 (de) 1996-09-11
PT83559A (en) 1986-11-01
DK496086D0 (da) 1986-10-16
CA1335450C (en) 1995-05-02
IE862737L (en) 1987-04-17
US4837235A (en) 1989-06-06
IL80336A (en) 1990-02-09
AU6398686A (en) 1987-04-30
FI864190A0 (fi) 1986-10-16
DK496086A (da) 1987-04-18
FI864190A (fi) 1987-04-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee