DE3641379A1 - Arzneimittel - Google Patents

Arzneimittel

Info

Publication number
DE3641379A1
DE3641379A1 DE19863641379 DE3641379A DE3641379A1 DE 3641379 A1 DE3641379 A1 DE 3641379A1 DE 19863641379 DE19863641379 DE 19863641379 DE 3641379 A DE3641379 A DE 3641379A DE 3641379 A1 DE3641379 A1 DE 3641379A1
Authority
DE
Germany
Prior art keywords
alkylamino
alkyl group
formula
substituted
unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19863641379
Other languages
German (de)
English (en)
Inventor
Hansjoerg Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to DE19863641379 priority Critical patent/DE3641379A1/de
Publication of DE3641379A1 publication Critical patent/DE3641379A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
DE19863641379 1985-12-04 1986-12-04 Arzneimittel Withdrawn DE3641379A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19863641379 DE3641379A1 (de) 1985-12-04 1986-12-04 Arzneimittel

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3542893 1985-12-04
DE3606631 1986-02-28
DE19863641379 DE3641379A1 (de) 1985-12-04 1986-12-04 Arzneimittel

Publications (1)

Publication Number Publication Date
DE3641379A1 true DE3641379A1 (de) 1987-09-03

Family

ID=25838509

Family Applications (4)

Application Number Title Priority Date Filing Date
DE19863641379 Withdrawn DE3641379A1 (de) 1985-12-04 1986-12-04 Arzneimittel
DE19375061C Active DE19375061I2 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE8686906829T Expired - Lifetime DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE19863641491 Withdrawn DE3641491A1 (de) 1985-12-04 1986-12-04 Arzneimittel mit antitumorwirkung

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE19375061C Active DE19375061I2 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE8686906829T Expired - Lifetime DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE19863641491 Withdrawn DE3641491A1 (de) 1985-12-04 1986-12-04 Arzneimittel mit antitumorwirkung

Country Status (15)

Country Link
US (2) US4837023A (OSRAM)
EP (4) EP0230575A3 (OSRAM)
JP (2) JPH0637393B2 (OSRAM)
AT (2) ATE75608T1 (OSRAM)
CA (2) CA1338627C (OSRAM)
DE (4) DE3641379A1 (OSRAM)
DK (2) DK172954B1 (OSRAM)
ES (2) ES2038215T3 (OSRAM)
FI (2) FI873363L (OSRAM)
GR (2) GR3002487T3 (OSRAM)
HU (2) HU203201B (OSRAM)
IE (2) IE59778B1 (OSRAM)
NO (2) NO174877C (OSRAM)
PT (2) PT83872B (OSRAM)
WO (2) WO1987003480A2 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4029747A1 (de) * 1989-09-27 1991-04-11 Asta Pharma Ag Verwendung von alkylphosphorsaeure-verbindungen zur bekaempfung von psoriasis-erkrankungen
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
EP0412941B1 (en) * 1989-08-10 1996-05-15 Sandoz Ltd. Phospholipids for the treatment of multiple sclerosis
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
DK0521297T3 (da) * 1991-07-04 1998-05-04 Asta Medica Ag Fremgangsmåde til fremstilling af alkylphosphocholiner og rensning heraf
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4235911A1 (de) * 1992-10-23 1994-04-28 Asta Medica Ag Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern
EP0702556B1 (en) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipids for combatting hepatitis b virus infection
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
DE69432930T2 (de) 1993-09-09 2004-05-06 Lorus Therapeutics Inc., Toronto Immunmodulierende zusammensetzungen aus galle
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
CA2197319C (en) 1994-08-29 2009-01-27 Louis S. Kucera Lipid analogs for treating viral infections
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
WO1996024598A1 (en) * 1995-02-10 1996-08-15 The University Of British Columbia [4-hexadecyl-3-methoxy-butyl] phosphonic acid and its protein conjugates useful as anti-cancer agents
CN1182368A (zh) 1995-03-16 1998-05-20 伊姆特克药物公司 来源于胆汁的治疗免疫系统紊乱的免疫调节组合物
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6121245A (en) * 1997-01-29 2000-09-19 Firshein; Richard N. Method of treating cancer using alkylglycerols in conjunction with chemotherapy
SE9701912D0 (sv) * 1997-05-22 1997-05-22 Interhealth Ab Pharmaceutical composition and use thereof
US7582678B2 (en) * 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
IL136196A (en) * 1998-01-22 2004-07-25 Zentaris Ag Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
IL137672A0 (en) 2000-08-03 2001-10-31 Dpharm Ltd Derivatives of branched-chain lipophilic molecules and uses thereof
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
KR20030041130A (ko) * 2001-05-29 2003-05-23 코닌클리케 필립스 일렉트로닉스 엔.브이. 금속-세라믹 접착
KR100871648B1 (ko) * 2001-08-31 2008-12-03 톰슨 라이센싱 조건부 액세스 시스템을 구현하는 방법, 컨텐트를 전송하는 방법 및 그 장치 및 컨텐트를 수신하고 처리하는 방법 및 그 장치
WO2003090757A1 (en) * 2002-04-26 2003-11-06 Rudolf Perl Pharmaceutical compositions of phospholipid derivatives
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
JP5232009B2 (ja) 2005-12-19 2013-07-10 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低減された細胞毒性を有するアルキルリン脂質誘導体並びにそれらの使用
WO2008074573A1 (en) * 2006-12-20 2008-06-26 Alphaptose Gmbh Topical dosage form comprising tri-substituted glycerol compounds
JP2011057647A (ja) * 2009-09-14 2011-03-24 Adeka Corp 化粧料
AU2012272642B2 (en) 2011-06-24 2017-09-07 Gri Bio, Inc. Prevention and treatment of inflammatory conditions
CN102491994B (zh) * 2011-12-07 2014-10-15 宁波九胜创新医药科技有限公司 一种胆碱磷酸烷基酯的制备方法
AU2015360945B2 (en) * 2014-12-09 2021-07-29 Gri Bio, Inc. Prevention and treatment of inflammatory conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
JPS60184092A (ja) 1984-03-01 1985-09-19 Kao Corp リン酸エステルおよびその製法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4029747A1 (de) * 1989-09-27 1991-04-11 Asta Pharma Ag Verwendung von alkylphosphorsaeure-verbindungen zur bekaempfung von psoriasis-erkrankungen
DE4029747C2 (de) * 1989-09-27 2003-10-02 Asta Medica Ag Verwendung von Hexadecylphosphocholin zur Behandlung von Psoriasis-Erkrankungen
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
US6479472B1 (en) 1992-07-11 2002-11-12 Asta Medica Aktiengesellschaft Methods of using therapeutic phospholipid derivatives
US6903080B2 (en) 1992-07-11 2005-06-07 Zentaris Gmbh Disease treatment with novel phospholipid derivatives

Also Published As

Publication number Publication date
GR3002487T3 (en) 1992-12-30
NO873244D0 (no) 1987-08-03
HUT44441A (en) 1988-03-28
HUT44431A (en) 1988-03-28
NO873243L (no) 1987-10-02
IE59778B1 (en) 1994-04-06
US5049552A (en) 1991-09-17
NO873243D0 (no) 1987-08-03
WO1987003478A3 (en) 1987-09-24
DE3679908D1 (de) 1991-07-25
HU208143B (en) 1993-08-30
FI873364A0 (fi) 1987-08-03
PT83872A (de) 1987-01-01
PT83872B (pt) 1989-01-17
FI873363A7 (fi) 1987-08-03
JPS63501719A (ja) 1988-07-14
HU203201B (en) 1991-06-28
ES2038215T3 (es) 1993-07-16
JPH0637393B2 (ja) 1994-05-18
DK172954B1 (da) 1999-10-18
ES2032755T3 (es) 1993-03-01
DK398587D0 (da) 1987-07-30
PT83873A (de) 1987-01-01
GR3005168T3 (OSRAM) 1993-05-24
US4837023A (en) 1989-06-06
NO873244L (no) 1987-10-01
NO175620B (OSRAM) 1994-08-01
EP0248062B1 (de) 1992-05-06
PT83873B (pt) 1989-01-17
EP0230575A2 (de) 1987-08-05
ATE64529T1 (de) 1991-07-15
DE3641491A1 (de) 1987-09-17
NO174877B (no) 1994-04-18
WO1987003480A3 (en) 1988-02-25
DK393187A (da) 1987-07-28
NO175620C (no) 1994-11-09
CA1280369C (en) 1991-02-19
EP0225608A3 (de) 1987-10-28
IE863177L (en) 1987-06-04
WO1987003478A2 (en) 1987-06-18
IE59777B1 (en) 1994-04-06
CA1338627C (en) 1996-10-01
JPH0859677A (ja) 1996-03-05
EP0248062A1 (de) 1987-12-09
IE863176L (en) 1987-06-04
FI873363A0 (fi) 1987-08-03
WO1987003480A2 (en) 1987-06-18
FI873363L (fi) 1987-08-03
EP0248047B1 (de) 1991-06-19
EP0225608A2 (de) 1987-06-16
JP2857084B2 (ja) 1999-02-10
EP0230575A3 (de) 1987-12-02
FI873364A7 (fi) 1987-08-03
ATE75608T1 (de) 1992-05-15
EP0248047A1 (de) 1987-12-09
NO174877C (no) 1994-07-27
DK393187D0 (da) 1987-07-28
DK398587A (da) 1987-07-30
DE19375061I2 (de) 2008-11-20

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination