DE3525256A1 - Naphthylanaloge von mevalonolactonen und deren derivaten, verfahren zu deren herstellung und deren verwendung - Google Patents
Naphthylanaloge von mevalonolactonen und deren derivaten, verfahren zu deren herstellung und deren verwendungInfo
- Publication number
- DE3525256A1 DE3525256A1 DE19853525256 DE3525256A DE3525256A1 DE 3525256 A1 DE3525256 A1 DE 3525256A1 DE 19853525256 DE19853525256 DE 19853525256 DE 3525256 A DE3525256 A DE 3525256A DE 3525256 A1 DE3525256 A1 DE 3525256A1
- Authority
- DE
- Germany
- Prior art keywords
- compound
- formula
- free acid
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63380984A | 1984-07-24 | 1984-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3525256A1 true DE3525256A1 (de) | 1986-01-30 |
Family
ID=24541204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853525256 Withdrawn DE3525256A1 (de) | 1984-07-24 | 1985-07-15 | Naphthylanaloge von mevalonolactonen und deren derivaten, verfahren zu deren herstellung und deren verwendung |
Country Status (21)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0344602A1 (de) * | 1988-06-01 | 1989-12-06 | Roche Diagnostics GmbH | 6-substituierte 4-Hydroxytetrahydro-Pyran-2-on-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf der Basis dieser Verbindungen |
| US5686433A (en) * | 1988-08-29 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904646A (en) * | 1987-05-22 | 1990-02-27 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-COA reductase inhibitors |
| US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
| DE3722807A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
| US4792614A (en) * | 1987-08-05 | 1988-12-20 | American Home Products Corporation | Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase |
| US4812583A (en) * | 1987-09-11 | 1989-03-14 | American Home Products Corporation | Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase |
| CA2185961A1 (en) * | 1996-09-19 | 1998-03-20 | K.S. Keshava Murthy | Process for producing simvastatin |
| US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
| KR100836960B1 (ko) | 2007-09-07 | 2008-06-10 | 주식회사 서울제약 | 새로운 나이아신 제어방출형 제제 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55132595A (en) * | 1979-04-04 | 1980-10-15 | Nec Corp | Semiconductor circuit |
-
1985
- 1985-07-12 NL NL8502010A patent/NL8502010A/nl not_active Application Discontinuation
- 1985-07-12 HU HU852696A patent/HUT39142A/hu unknown
- 1985-07-15 DE DE19853525256 patent/DE3525256A1/de not_active Withdrawn
- 1985-07-16 FR FR8510988A patent/FR2568248A1/fr active Pending
- 1985-07-17 BE BE1/011302A patent/BE902914A/fr not_active IP Right Cessation
- 1985-07-22 IL IL75874A patent/IL75874A0/xx unknown
- 1985-07-22 DK DK333785A patent/DK333785A/da not_active Application Discontinuation
- 1985-07-22 PH PH32550A patent/PH21444A/en unknown
- 1985-07-22 LU LU86012A patent/LU86012A1/fr unknown
- 1985-07-22 ES ES545454A patent/ES8705356A1/es not_active Expired
- 1985-07-22 GR GR851805A patent/GR851805B/el unknown
- 1985-07-22 SE SE8503556A patent/SE8503556L/xx not_active Application Discontinuation
- 1985-07-22 PT PT80845A patent/PT80845B/pt unknown
- 1985-07-22 FI FI852851A patent/FI852851L/fi not_active Application Discontinuation
- 1985-07-22 KR KR1019850005206A patent/KR860001045A/ko not_active Ceased
- 1985-07-22 GB GB08518490A patent/GB2162179A/en not_active Withdrawn
- 1985-07-22 AU AU45226/85A patent/AU4522685A/en not_active Abandoned
- 1985-07-23 PL PL25465485A patent/PL254654A1/xx unknown
- 1985-07-23 IT IT8548385A patent/IT1200095B/it active
- 1985-07-23 JP JP16278685A patent/JPS6137754A/ja active Pending
- 1985-07-24 ZA ZA855594A patent/ZA855594B/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0344602A1 (de) * | 1988-06-01 | 1989-12-06 | Roche Diagnostics GmbH | 6-substituierte 4-Hydroxytetrahydro-Pyran-2-on-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf der Basis dieser Verbindungen |
| US5686433A (en) * | 1988-08-29 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors |
| US5691322A (en) * | 1988-08-29 | 1997-11-25 | E.R. Squibb & Sons, Inc. | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4522685A (en) | 1986-01-30 |
| FR2568248A1 (fr) | 1986-01-31 |
| LU86012A1 (fr) | 1986-02-12 |
| IL75874A0 (en) | 1985-11-29 |
| PT80845A (en) | 1985-08-01 |
| FI852851A7 (fi) | 1986-01-25 |
| BE902914A (fr) | 1986-01-17 |
| PT80845B (en) | 1987-03-24 |
| FI852851A0 (fi) | 1985-07-22 |
| FI852851L (fi) | 1986-01-25 |
| SE8503556D0 (sv) | 1985-07-22 |
| KR860001045A (ko) | 1986-02-22 |
| DK333785D0 (da) | 1985-07-22 |
| ES545454A0 (es) | 1987-05-01 |
| GR851805B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) | 1985-11-26 |
| NL8502010A (nl) | 1986-02-17 |
| DK333785A (da) | 1986-01-25 |
| HUT39142A (en) | 1986-08-28 |
| ZA855594B (en) | 1987-02-25 |
| GB2162179A (en) | 1986-01-29 |
| JPS6137754A (ja) | 1986-02-22 |
| PH21444A (en) | 1987-10-20 |
| IT8548385A0 (it) | 1985-07-23 |
| PL254654A1 (en) | 1986-08-26 |
| GB8518490D0 (en) | 1985-08-29 |
| ES8705356A1 (es) | 1987-05-01 |
| SE8503556L (sv) | 1986-01-25 |
| IT1200095B (it) | 1989-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |