ES8705356A1 - Procedimiento para la preparacion de compuestos naftil-ana- logos de mevalonolactona y sus derivados - Google Patents

Procedimiento para la preparacion de compuestos naftil-ana- logos de mevalonolactona y sus derivados

Info

Publication number
ES8705356A1
ES8705356A1 ES545454A ES545454A ES8705356A1 ES 8705356 A1 ES8705356 A1 ES 8705356A1 ES 545454 A ES545454 A ES 545454A ES 545454 A ES545454 A ES 545454A ES 8705356 A1 ES8705356 A1 ES 8705356A1
Authority
ES
Spain
Prior art keywords
mevalonolactone
derivatives
processes
production
naphthyl analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545454A
Other languages
English (en)
Other versions
ES545454A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES545454A0 publication Critical patent/ES545454A0/es
Publication of ES8705356A1 publication Critical patent/ES8705356A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I). CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (I) EN FORMA DE ESTER O DE LACTONA, EN ETANOL, EN PRESENCIA DE HIDROXIDO SODICO PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R1 REPRESENTA ALQUILO C1-3, Y Z PUEDE SER UNO DE VARIOS TIPOS DE RADICALES; SEGUIDA DE LA RECUPERACION DE DICHO COMPUESTO EN FORMA DE SAL, O EN FORMA DE ACIDO, PREVIA ACIDIFICACION DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA HIPERLIPOPROTEINEMIA Y LA ARTERIOSCLEROSIS.
ES545454A 1984-07-24 1985-07-22 Procedimiento para la preparacion de compuestos naftil-ana- logos de mevalonolactona y sus derivados Expired ES8705356A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63380984A 1984-07-24 1984-07-24

Publications (2)

Publication Number Publication Date
ES545454A0 ES545454A0 (es) 1987-05-01
ES8705356A1 true ES8705356A1 (es) 1987-05-01

Family

ID=24541204

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545454A Expired ES8705356A1 (es) 1984-07-24 1985-07-22 Procedimiento para la preparacion de compuestos naftil-ana- logos de mevalonolactona y sus derivados

Country Status (21)

Country Link
JP (1) JPS6137754A (es)
KR (1) KR860001045A (es)
AU (1) AU4522685A (es)
BE (1) BE902914A (es)
DE (1) DE3525256A1 (es)
DK (1) DK333785A (es)
ES (1) ES8705356A1 (es)
FI (1) FI852851L (es)
FR (1) FR2568248A1 (es)
GB (1) GB2162179A (es)
GR (1) GR851805B (es)
HU (1) HUT39142A (es)
IL (1) IL75874A0 (es)
IT (1) IT1200095B (es)
LU (1) LU86012A1 (es)
NL (1) NL8502010A (es)
PH (1) PH21444A (es)
PL (1) PL254654A1 (es)
PT (1) PT80845B (es)
SE (1) SE8503556L (es)
ZA (1) ZA855594B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US4904646A (en) * 1987-05-22 1990-02-27 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-COA reductase inhibitors
DE3722807A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4792614A (en) * 1987-08-05 1988-12-20 American Home Products Corporation Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase
US4812583A (en) * 1987-09-11 1989-03-14 American Home Products Corporation Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase
DE3818570A1 (de) * 1988-06-01 1989-12-21 Boehringer Mannheim Gmbh Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
KR100836960B1 (ko) 2007-09-07 2008-06-10 주식회사 서울제약 새로운 나이아신 제어방출형 제제

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55132595A (en) * 1979-04-04 1980-10-15 Nec Corp Semiconductor circuit

Also Published As

Publication number Publication date
PT80845A (en) 1985-08-01
JPS6137754A (ja) 1986-02-22
IT1200095B (it) 1989-01-05
AU4522685A (en) 1986-01-30
BE902914A (fr) 1986-01-17
SE8503556L (sv) 1986-01-25
ES545454A0 (es) 1987-05-01
DE3525256A1 (de) 1986-01-30
SE8503556D0 (sv) 1985-07-22
FI852851L (fi) 1986-01-25
IL75874A0 (en) 1985-11-29
GB2162179A (en) 1986-01-29
GR851805B (es) 1985-11-26
FI852851A0 (fi) 1985-07-22
FR2568248A1 (fr) 1986-01-31
PT80845B (en) 1987-03-24
PL254654A1 (en) 1986-08-26
PH21444A (en) 1987-10-20
LU86012A1 (fr) 1986-02-12
GB8518490D0 (en) 1985-08-29
NL8502010A (nl) 1986-02-17
IT8548385A0 (it) 1985-07-23
ZA855594B (en) 1987-02-25
DK333785D0 (da) 1985-07-22
HUT39142A (en) 1986-08-28
KR860001045A (ko) 1986-02-22
DK333785A (da) 1986-01-25

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