DE3486474T2 - Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit - Google Patents

Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit

Info

Publication number
DE3486474T2
DE3486474T2 DE3486474T DE3486474T DE3486474T2 DE 3486474 T2 DE3486474 T2 DE 3486474T2 DE 3486474 T DE3486474 T DE 3486474T DE 3486474 T DE3486474 T DE 3486474T DE 3486474 T2 DE3486474 T2 DE 3486474T2
Authority
DE
Germany
Prior art keywords
met42
val55
products
production
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3486474T
Other languages
English (en)
Other versions
DE3486474D1 (de
Inventor
Vemuri B Reddy
Nancy Hsing
Anton K Beck
Edward G Bernstine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24187868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3486474(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of DE3486474D1 publication Critical patent/DE3486474D1/de
Publication of DE3486474T2 publication Critical patent/DE3486474T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
DE3486474T 1983-11-02 1984-10-31 Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit Expired - Lifetime DE3486474T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54821183A 1983-11-02 1983-11-02

Publications (2)

Publication Number Publication Date
DE3486474D1 DE3486474D1 (de) 2000-02-03
DE3486474T2 true DE3486474T2 (de) 2000-08-03

Family

ID=24187868

Family Applications (4)

Application Number Title Priority Date Filing Date
DE3486474T Expired - Lifetime DE3486474T2 (de) 1983-11-02 1984-10-31 Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit
DE2001199028 Active DE10199028I2 (de) 1983-11-02 1984-10-31 Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
DE2001199035 Active DE10199035I2 (de) 1983-11-02 1984-10-31 Herstellung heterodimerer menschlicher Fruchtbarkeitshormone
DE3486469T Expired - Lifetime DE3486469T2 (de) 1983-11-02 1984-10-31 Herstellung heterodimirer menschlicher Fruchtbarkeitshormone

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE2001199028 Active DE10199028I2 (de) 1983-11-02 1984-10-31 Produkte und Methoden für die Herstellung einer heterodimerer menschlicher LH mit einem Met42 Val55 alpha Untereinheit.
DE2001199035 Active DE10199035I2 (de) 1983-11-02 1984-10-31 Herstellung heterodimerer menschlicher Fruchtbarkeitshormone
DE3486469T Expired - Lifetime DE3486469T2 (de) 1983-11-02 1984-10-31 Herstellung heterodimirer menschlicher Fruchtbarkeitshormone

Country Status (8)

Country Link
EP (3) EP0578328B1 (de)
AT (2) ATE169334T1 (de)
DE (4) DE3486474T2 (de)
DK (2) DK297285A (de)
LU (1) LU90770I2 (de)
MX (1) MX9203334A (de)
NL (1) NL300044I2 (de)
WO (1) WO1985001959A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
AU5993186A (en) * 1985-06-04 1987-01-07 Biotechnology Research Partners Limited Autoantigen vaccines
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
KR960704932A (ko) * 1994-08-12 1996-10-09 에이치. 에스. 리헤이 당단백질 호르몬 4개조의 단일-사슬 형태(single-chain forms of the glycoprotein hormone quartet)
BR9506313A (pt) * 1994-08-12 1997-08-05 Univ Washington Formas de cadeia simples do quarteto de hormônio de glicoproteína
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (de) 1998-12-15 2000-06-28 Applied Research Systems ARS Holding N.V. hCG Therapie für Behandlung von Brustkrebs
EP1169053A1 (de) 1999-04-13 2002-01-09 Inhale Therapeutic Systems, Inc. Verabreichung von trockenpulverformulierungen über die lungen zur behandlung der unfruchtbarkeit
MXPA04004289A (es) * 2001-11-08 2005-03-31 William R Moyle Proteina knobs.
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080052650A (ko) 2005-09-07 2008-06-11 라보라토리스 세로노 에스.에이. 자궁내막증 치료용 ｉｋｋ 저해제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048894A (en) * 1979-05-11 1980-12-17 Gist Brocades Nv Plasmid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
ATE169334T1 (de) 1998-08-15
DE10199028I2 (de) 2004-07-01
EP0160699B1 (de) 1992-08-12
DE3486474D1 (de) 2000-02-03
EP0578328B1 (de) 1999-12-29
EP0160699A1 (de) 1985-11-13
LU90770I2 (fr) 2001-07-03
NL300044I1 (nl) 2001-07-02
MX9203334A (es) 1992-09-01
DE10199035I2 (de) 2006-03-16
DK297185A (da) 1985-07-01
EP0578328A1 (de) 1994-01-12
ATE190461T1 (de) 2000-04-15
WO1985001959A1 (en) 1985-05-09
DK297185D0 (da) 1985-07-01
DK171489B1 (da) 1996-11-25
EP0957167A1 (de) 1999-11-17
DK297285D0 (da) 1985-07-01
DE10199028I1 (de) 2001-09-20
NL300044I2 (nl) 2001-12-01
EP0160699A4 (de) 1987-10-20
DE3486469T2 (de) 1999-04-15
DK297285A (da) 1985-07-01
DE3486469D1 (de) 1998-09-10
DE10199035I1 (de) 2001-11-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: LUTROPIN ALFA (REKOMBINANTES HUMANES LUTEINISIERENDES HORMON (LH)); REGISTRATION NO/DATE: EU/1/00/155/001 - EU/1/00/155/006; 20001129

Spc suppl protection certif: 101 99 028

Filing date: 20010518

8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 81476 MUENCHEN

V457 Spc granted

Free format text: PRODUCT NAME: LUTROPIN ALFA (REKOMBINANTES HUMANES LUTEINISIERENDES HORMON (LH)); REGISTRATION NO/DATE: EU/1/00/155/001 - EU/1/00/155/006; 20001129

Spc suppl protection certif: 101 99 028

Filing date: 20010518

V464 Spc expired

Free format text: PRODUCT NAME: LUTROPIN ALFA (REKOMBINANTES HUMANES LUTEINISIERENDES HORMON (LH)); REGISTRATION NO/DATE: EU/1/00/155/001 - EU/1/00/155/006; 20001129

Spc suppl protection certif: 101 99 028

Filing date: 20010518